Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans

Journal of Nutrition

Volumn 128, Issue 2, 1998, Pages 198-203

  Volpi, Elena ^a   Lucidi, Paola ^a   Cruciani, Guido ^a   Monacchia, Francesca ^a   Santoni, Stefania ^a   Reboldi, Gianpaolo ^a   Brunetti, Paolo ^a   Bolli, Geremia B ^a   De Feo, Pierpaolo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Albumin; Fibrinogen; Humans; Leucine metabolism; Protein synthesis

Indexed keywords

2 OXOISOCAPROIC ACID; ALBUMIN; ALCOHOL; AMINO ACID; CARBON 14; CARBON DIOXIDE; FIBRINOGEN; GLUCOSE; INSULIN; ISOLEUCINE; LACTIC ACID; LEUCINE; LIPID; PLASMA PROTEIN; PROTEIN; PYRUVIC ACID;

ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIVER; MALE; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

EID: 0031915008     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.2.198     Document Type: Article

References (21)

1. + in rat hepatocytes. Hepatology 13: 509-514.
2. Baraona, E., Pikkarainen, P., Salaspuro, M., Finkelman, F. & Lieber, C. S. (1980) Acute effects of ethanol on hepatic protein synthesis and secretion in the rat. Gastroenterology 79: 104-111.
3. Berry, M. N., Gregory, R. B., Grivell, A. R., Phillips, J. W. & Schon, A. (1994) The capacity of reducing-equivalent shuttles limits glycolysis during ethanol oxidation. Eur. J. Biochem. 225: 557-564.
4. De Feo, P. & Haymond, M. W. (1992) Effects of substrates on protein metabolism in humans. In: Protein Metabolism in Diabetes Mellitus (Nair, K. S., ed.), pp. 199-206. Eldred Smith-Gordon, London, UK.
5. De Feo, P. & Haymond, M. W. (1994) Principles and calculations of the labelled leucine methodology to estimate protein kinetics in humans. Diabetes Nutr. Metab. 7: 165-184.
6. De Feo, P., Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Reboldi, G., Santeusanio, F., Bolli, G. B. & Brunetti, P. (1995) Ethanol impairs post-prandial hepatic protein metabolism. J. Clin. Invest. 95: 1472-1479.
7. Facchini, F., Chen, I.Y.-D. & Reaven, G. M. (1994) Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 17: 115-119.
8. French, S. W. (1989) Biochemical basis for alcohol-induced liver injury. Clin. Biochem. 22: 41-49.
9. Gaziano, M. J., Buring, J. E., Breslow, J. L., Goldhaber, S. Z., Rosner, B., VanDenburgh, M., Willett, W. & Hennekens, C. H. (1993) Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N. Engl. J. Med. 329: 1829-1834.
10. Holsen, C. (1971) An enzymatic fluorimetric micromethod for the determination of acetoacetate, β-hydroxybutirate, pyruvate and lactate. Clin. Chim. Acta 33: 293-300.
11. Horber, F. F., Kahl, J., Lecavalier, L., Krom, B. & Haymond, M. W. (1989) Determination of leucine and α-ketoisocaproic acid concentrations and specific activity in plasma and leucine specific activities in proteins using high-performance liquid chromatography. J. Chromatogr. 495: 81-94.
12. Lieber, C. S. (1980) Alcohol, protein metabolism, and liver injury. Gastroenterology 79: 373-390.
13. Madison, L. L., Lochner, A. & Wulff, J. (1967) Ethanol induced hypoglycemia. Mechanism of suppression of hepatic gluconeogenesis. Diabetes 16: 252-258.
14. Masson, S., Desmoulin, F., Sciaky, M. & Cozzone, P. J. (1993) Catabolism of adenine nucleotides and its relation with intracellular phosphorylated metabolite concentration during ethanol oxidation in perfused rat liver. Biochemistry 32: 1025-1031.
15. Newsholme, E. A. & Leech, A. R. (1983) Biochemistry for the Medical Sciences, pp. 472-478. John Wiley & Sons, Chichester, UK.
16. Schwenk, W. F., Beaufrere, B. & Haymond, M. W. (1985) Use of reciprocal pool specific activities to model leucine metabolism in humans. Am. J. Physiol. 249: E646-E650.
17. Snedecor, G. W. & Cochran, W. G. (1980) Statistical Methods, 7th ed. Iowa State University Press, Ames, IA.
18. Tuma, D. J., Jennett, R. B. & Sorrell, M. F. (1987) The interaction of acetaldehyde with tubulin. Ann. N.Y. Acad. Sci. 492: 277-286.
19. Volpi, E., Lucidi, P., Cruciani, C., Monacchia, F., Reboldi, G., Brunetti, P., Bolli, G. B. & De Feo, P. (1996) Contribution of amino acids and insulin to protein anabolism during meal absorption. Diabetes 45: 1245-1252.
20. Volpi, E., Lucidi, P., Cruciani, C., Monacchia, F., Reboldi, G., Brunetti, P., Bolli, G. B. & De Feo, P. (1997) Nicotinamide counteracts alcohol-induced impairment of hepatic protein metabolism in humans. J. Nutr. 127: 2199-2204.
21. Winer, B. J. (1972) Statistical Principles in Experimental Design, 2nd ed., pp. 261-308. McGraw-Hill, New York, NY.