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Volumn 93, Issue 2, 1998, Pages 171-176

Inherent properties of somatic hypermutation as revealed by human non- productive V(H)6 immunoglobulin rearrangements

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN;

EID: 0031912042     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00427.x     Document Type: Article
Times cited : (9)

References (29)
  • 1
    • 0024362047 scopus 로고
    • The role of somatic hypermutation in the generation of antibody diversity
    • FRENCH D.L., LASKOV R. & SCHARFF M.D. (1989) The role of somatic hypermutation in the generation of antibody diversity. Science 244, 1152.
    • (1989) Science , vol.244 , pp. 1152
    • French, D.L.1    Laskov, R.2    Scharff, M.D.3
  • 2
    • 0024327901 scopus 로고
    • Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways
    • KOCKS C. & RAJEWSKY K. (1989) Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Annu Rev Immunol 7, 537.
    • (1989) Annu Rev Immunol , vol.7 , pp. 537
    • Kocks, C.1    Rajewsky, K.2
  • 3
    • 0029872907 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • WAGNER S.D. & NEUBERGER M.S. (1996) Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol 14, 441.
    • (1996) Annu Rev Immunol , vol.14 , pp. 441
    • Wagner, S.D.1    Neuberger, M.S.2
  • 5
    • 0027190704 scopus 로고
    • H rearrangement expressed with IgM, IgG, and IgA
    • H rearrangement expressed with IgM, IgG, and IgA. J Clin Invest 91, 1838.
    • (1993) J Clin Invest , vol.91 , pp. 1838
    • Varade, W.S.1    Insel, R.A.2
  • 7
    • 0028226831 scopus 로고
    • Human splenic IgM immunoglobulin transcripts are mutated at high frequency
    • INSEL R.A., MARIN E. & VARADE W.S. (1994) Human splenic IgM immunoglobulin transcripts are mutated at high frequency. Molec Immunol 31, 383.
    • (1994) Molec Immunol , vol.31 , pp. 383
    • Insel, R.A.1    Marin, E.2    Varade, W.S.3
  • 9
    • 0023107028 scopus 로고
    • Patterns of somatic mutations in immunoglobulin variable genes
    • GOLDING G.B., GEARHART P.J. & GLICKMAN B.W. (1987) Patterns of somatic mutations in immunoglobulin variable genes. Genetics 115, 169.
    • (1987) Genetics , vol.115 , pp. 169
    • Golding, G.B.1    Gearhart, P.J.2    Glickman, B.W.3
  • 10
    • 0027364313 scopus 로고
    • Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes
    • GONZÁLEZ-FERNÁNDEZ A. & MILSTEIN C. (1993) Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes. Proc Natl Acad Sci USA 90, 9862.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9862
    • González-Fernández, A.1    Milstein, C.2
  • 11
    • 0028577994 scopus 로고
    • Somatic mutation of immunoglobulin lambda chains: A segment of the major intron hypermutates as much as the complementarity-determining regions
    • GONZÁLEZ-FERNÁNDEZ A., GUPTA S.K., PANNEL R., NEUBERGER M.S. & MILSTEIN, C. (1994) Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc Natl Acad Sci USA 91, 12 614.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12614
    • González-Fernández, A.1    Gupta, S.K.2    Pannel, R.3    Neuberger, M.S.4    Milstein, C.5
  • 12
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutalion mechanism: Clustering, polarity and specific hot spots
    • BETZ A.G., RADA C., PANNELL R., MILSTEIN C. & NEUBERGER M.S. (1993) Passenger transgenes reveal intrinsic specificity of the antibody hypermutalion mechanism: clustering, polarity and specific hot spots. Proc Natl Acad Sci USA 90, 2385.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2385
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 13
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • BETZ A.G., MILSTEIN C., GONZÁLEZ-FERNÁNDEZ A., PANNELL R., LARSEN T. & NEUBERGER M.S. (1994) Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77, 239.
    • (1994) Cell , vol.77 , pp. 239
    • Betz, A.G.1    Milstein, C.2    González-Fernández, A.3    Pannell, R.4    Larsen, T.5    Neuberger, M.S.6
  • 14
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of v region mutation and selection in germinal center B cells
    • JACOB J., PRZYLEPA J., MILLER C. & KELSOE G. (1993) In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of v region mutation and selection in germinal center B cells. J Exp Med 178, 1293.
    • (1993) J Exp Med , vol.178 , pp. 1293
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 15
    • 0027428398 scopus 로고
    • Expressed human immunoglobulin κ genes and their hypermutation
    • KLEIN R., JAENICHEN R. & ZACHAU H.G. (1993) Expressed human immunoglobulin κ genes and their hypermutation. Eur J Immunol 23, 3248.
    • (1993) Eur J Immunol , vol.23 , pp. 3248
    • Klein, R.1    Jaenichen, R.2    Zachau, H.G.3
  • 16
    • 0030450401 scopus 로고    scopus 로고
    • Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutalion
    • GOYENECHEA B. & MILSTEIN C. (1996) Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutalion. Proc Natl Acad Sci USA 93, 13 979.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13979
    • Goyenechea, B.1    Milstein, C.2
  • 17
    • 0027932998 scopus 로고
    • H genes are inherently susceptible to amino acid replacement
    • H genes are inherently susceptible to amino acid replacement. Immunol Today 15, 367.
    • (1994) Immunol Today , vol.15 , pp. 367
    • Chang, B.1    Casali, P.2
  • 19
    • 0024517665 scopus 로고
    • V gene rearrangement is required to fully activate the hypermutation mechanism in B cells
    • ROES J., HUPPI K., RAJEWSKY K. & SABLITZKY F. (1989) V gene rearrangement is required to fully activate the hypermutation mechanism in B cells. J Immunol 142, 1022.
    • (1989) J Immunol , vol.142 , pp. 1022
    • Roes, J.1    Huppi, K.2    Rajewsky, K.3    Sablitzky, F.4
  • 22
    • 0028986982 scopus 로고
    • The human immunoglobulin VH repertoire
    • COOK G.P. & TOMLINSON I.M. (1995) The human immunoglobulin VH repertoire. Immunol Today 16, 237.
    • (1995) Immunol Today , vol.16 , pp. 237
    • Cook, G.P.1    Tomlinson, I.M.2
  • 23
    • 0029947265 scopus 로고    scopus 로고
    • Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
    • SMITH D.S., CREADON G., JENA P.K., PORTANOVA J.P., KOTZIN B.L. & WYSOCKI L.J. (1996) Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J Immunol 156, 2642.
    • (1996) J Immunol , vol.156 , pp. 2642
    • Smith, D.S.1    Creadon, G.2    Jena, P.K.3    Portanova, J.P.4    Kotzin, B.L.5    Wysocki, L.J.6
  • 25
    • 0027409765 scopus 로고
    • High-frequency representation of a single VH gene in the expressed human B cell repertoire
    • STEWART A.K., HUANG C., STOLLAR B.D. & SCHWARTZ R.S. (1993) High-frequency representation of a single VH gene in the expressed human B cell repertoire. J Exp Med 177, 409.
    • (1993) J Exp Med , vol.177 , pp. 409
    • Stewart, A.K.1    Huang, C.2    Stollar, B.D.3    Schwartz, R.S.4
  • 26
    • 0031569118 scopus 로고    scopus 로고
    • Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
    • DÖRNER T., BREZINSCHEK H.-P., BREZINSCHEK R.I., FOSTER S.J., DOMIATI-SAAD R. & LIPSKY P.E. (1997) Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 158, 2779.
    • (1997) J Immunol , vol.158 , pp. 2779
    • Dörner, T.1    Brezinschek, H.-P.2    Brezinschek, R.I.3    Foster, S.J.4    Domiati-Saad, R.5    Lipsky, P.E.6
  • 27
    • 0030071459 scopus 로고    scopus 로고
    • Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line
    • WU H. & KAARTINEN M. (1996) Distribution and nucleotide biases of the somatic hypermutations in the functional kappa light chain gene of a human follicular lymphoma line. Scand J Immunol 43, 193.
    • (1996) Scand J Immunol , vol.43 , pp. 193
    • Wu, H.1    Kaartinen, M.2
  • 28
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • ROGOZIN I.B. & KOLCHANOV N.A. (1992) Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophys Acta 1171, 11.
    • (1992) Biochim Biophys Acta , vol.1171 , pp. 11
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 29
    • 0025921606 scopus 로고
    • Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution
    • MEEK K., EVERSOLE T. & CAPRA, J.D. (1991) Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution. J Immunol 146, 2434.
    • (1991) J Immunol , vol.146 , pp. 2434
    • Meek, K.1    Eversole, T.2    Capra, J.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.