Oral glutamine slows down whole body protein breakdown in Duchenne muscular dystrophy

Pediatric Research

Volumn 43, Issue 2, 1998, Pages 222-226

  Hankard, Régis G ^a,b   Hammond, David ^a   Haymond, Morey W ^a   Darmaun, Dominique ^a  

^a NEMOURS CHILDREN S CLINIC   (United States)

^b HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; GLUTAMINE; LEUCINE; NITROGEN 15;

ADOLESCENT; AMINO ACID METABOLISM; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE DILUTION ASSAY; MALE; MUSCLE DISEASE; MUSCLE MASS; MUSCLE WEAKNESS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

EID: 0031911224     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199802000-00011     Document Type: Article

References (34)

1. Hoffman E, Fischbeck K, Brown R, Johnson M, Medori R, Loike J, Harris J, Waterston R 1988 Characterization of dystrophin in muscle biopsy specimens from patients with Duchenne's or Backer's muscular dystrophy. N Engl J Med 318:1363-1368
2. Mendell J, Kissel J, Amato A, King W, Signore L, Prior T, Sahenk Z, Benson S, McAndrew P, Rice R, Nagaraja H, Stephens R, Lantry L, Morris G, Burghes A 1995 Myoblast transfer in the treatment of Duchenne's muscular dystrophy. N Engl J Med 333:832-838
3. Hankard R, Gottrand F, Turck D, Carpentier A, Romon M, Farriaux J 1996 Resting energy expenditure and energy substrate utilization in children with Duchenne muscular dystrophy. Pediatr Res 40:1-5
4. Hübner C, Lehr H-A, Bodlaj R, Finckh B, Oexle K, Marklund S, Freudenberg K, Kontush A, Speer A, Terwolbeck K, Voit T, Kohlschütter A 1996 Wheat kernel ingestion protects from progression of muscle weakness in mdx mice, an animal model of Duchenne muscular dystrophy. Pediatr Res 40:444-449
5. Bergström J, Fürst P, Norée L, Vinnars E 1974 Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 36:693-697
6. Jepson M, Bates P, Broadbent P, Pell J, Millward D 1988 Relationship between glutamine concentration and protein synthesis in rat skeletal muscle. Am J Physiol 255:E166-E172
7. Hankard R, Haymond M, Darmaun D 1996 Effect of glutamine on leucine metabolism in humans. Am J Physiol 271:E748-E754
8. Vinnars E, Bergstöm J, Fürst P 1975 Influence of the post operative state on the intracellular free amino acids in human muscle tissue. Ann Surg 182:665-671
9. Wernerman J, Hammarqvist F, Vinnars E 1990 α-Ketoglutarate and postoperative muscle catabolism. Lancet 335:701-703
10. Rennie M 1984 Leucine metabolism in skeletal muscle and whole body in normal men and patients with a muscle disease. In: Serratice, G, Denvelle C, Pellicier J (eds) Neuromuscular Diseases. Raven Press, New York, pp 37-40
11. Rennie M, MacLennan P, Hundal H, Weryk B, Smith K, Taylor P, Egan C, Watt P 1989 Skeletal muscle glutamine transport, intramuscular glutamine concentration, and muscle-protein turnover. Metabolism 38:47-51
12. Rennie M, Edwards R, Millward D, Wolman S, Halliday D, Matthews D 1982 Effects of Duchenne muscular dystrophy on muscle protein synthesis. Nature 296:165-167
13. 13C]leucine. Am J Physiol 238:E473-E479
14. Griffiths R, Edwards R 1988 A new chart for weight control in Duchenne muscular dystrophy. Arch Dis Child 63:1256-1258
15. 13C]leucine infusion in man: a tracer method for measuring human intracellular leucine tracer enrichment. Metabolism 31:1105-1111
16. Darmaun D, Manary M, Matthews D 1985 A method for measuring both glutamine and glutamate levels and stable isotope enrichments. Anal Biochem 147:97-102
17. Horber F, Horber-Feyder C, Krayer S, Schwenk W, Haymond M 1989 Plasma reciprocal pool specific activity predicts that of intracellular free leucine for protein synthesis. Am J Physiol 257:E385-E399
18. Hankard R, Darmaun D, Sager B, D'Amore B, Parsons R, Haymond M 1995 Response of glutamine metabolism to exogenous glutamine in humans. Am J Physiol 269:E663-E670
19. Darmaun D, Matthews D, Bier D 1986 Glutamine and glutamate kinetics in humans. Am J Physiol 251:E117-E126
20. MacLennan P, Smith K, Weryk B, Watt P, Rennie M 1988 Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle. FEBS Lett 237:133-136
21. Buck M, Chojkier M 1996 Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J 15:1753-1765
22. Griggs RC, Rennie MJ 1983 Muscle wasting in muscular dystrophy: decreased protein synthesis or increased degradation? Ann Neurol 13:125-132
23. Li J 1980 Protein synthesis and degradation in skeletal muscle of normal and dystrophic hamsters. Am J Physiol 239:E401-E406
24. Turner P, Westwood T, Regen C, Steinhardt R 1988 Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice. Nature 335: 735-738
25. Zdanowicz M, Slonim A, Bilaniuk I, O'Connor M, Moyse J, Teichberg S 1995 High protein diet has beneficial effects in murine muscular dystrophy. J Nutr 125:1150-1158
26. 3. Pediatr Res 19:806-818
27. Rifai Z, Welle S, Moxley R, Lorenson M, Griggs R 1995 Effect of prednisone on protein metabolism in Duchenne dystrophy. Am J Physiol 268:E67-E74
28. Beaufrere B, Horber F, Schwenk F, Marsh H, Matthews D, Gerich J, Haymond M 1989 Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. Am J Physiol 257:E712-E721
29. Darmaun D, Matthews D, Bier D 1988 Physiological hypercortisolemia increases proteolysis, glutamine, and alanine production. Am J Physiol 255:E366-E373
30. 1 in dystrophic patient muscles correlates with fibrosis. J Clin Invest 96:1137-1144
31. Smith R, Larson S, Stred S, Durschlag R 1984 Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells. J Cell Physiol 120:197-203
32. Hankard R, Goulet O, Ricour C, Rongier M, Colomb V, Darmaun D 1994 Glutamine metabolism in children with short-bowel syndrome: a stable isotope study. Pediatr Res 36:202-206
33. Darmaun D, Messing B, Just B, Rongier M, Desjeux J 1991 Glutamine metabolism after small intestinal resection in humans. Metabolism 40:42-44
34. Darmaun D. Déchelotte P 1991 Role of leucine as a precursor of glutamine α-amino nitrogen in vivo in humans. Am J Physiol 260:E326-E329