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Volumn 257, Issue 4, 1998, Pages 421-432

Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum

Author keywords

Fusarium sporotrichioides; Gene cluster; Macrocyclic trichothecenes; Myrothecium roridium; TRI4 TRI5 TRI6

Indexed keywords

FUNGAL DNA; FUNGAL PROTEIN; GENE PRODUCT; SYNTHETASE; T 2 TOXIN; TRANSCRIPTION FACTOR; TRICHOTHECENE DERIVATIVE; UNSPECIFIC MONOOXYGENASE; ZINC FINGER PROTEIN;

EID: 0031910079     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050666     Document Type: Article
Times cited : (85)

References (49)
  • 1
    • 0031975577 scopus 로고    scopus 로고
    • The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis
    • in press
    • Alexander N, Hohn TM, McCormick SP (1998) The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis. Appl Environ Microbiol, in press
    • (1998) Appl Environ Microbiol
    • Alexander, N.1    Hohn, T.M.2    McCormick, S.P.3
  • 3
    • 0021177275 scopus 로고
    • The isolation and identification of trichothecene metabolites from a plant pathogenic strain of Myrothecium roridum
    • Bean GA, Fernando T, Jarvis BB, Burton B (1984) The isolation and identification of trichothecene metabolites from a plant pathogenic strain of Myrothecium roridum. J Nat Prod 47:727-729
    • (1984) J Nat Prod , vol.47 , pp. 727-729
    • Bean, G.A.1    Fernando, T.2    Jarvis, B.B.3    Burton, B.4
  • 4
    • 0012326192 scopus 로고
    • Biosynthesis and regulation of trichothecene production by Fusarium species
    • Bhatnagar D, Lillihoj EB, Arora DK (eds), Mycotoxins in ecological systems. Marcel Dekker, New York
    • Beremand MN, McCormick SP (1992) Biosynthesis and regulation of trichothecene production by Fusarium species. In: Bhatnagar D, Lillihoj EB, Arora DK (eds) Handbook of applied mycology, vol 5. Mycotoxins in ecological systems. Marcel Dekker, New York, pp 359-384
    • (1992) Handbook of Applied Mycology , vol.5 , pp. 359-384
    • Beremand, M.N.1    McCormick, S.P.2
  • 6
    • 0028029137 scopus 로고
    • Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted gene disruption
    • Brakhage AA, Browne P, Turner G (1994) Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted gene disruption. Mol Gen Genet 242:57-64
    • (1994) Mol Gen Genet , vol.242 , pp. 57-64
    • Brakhage, A.A.1    Browne, P.2    Turner, G.3
  • 8
    • 0000367621 scopus 로고
    • Cyclonerodiol biosynthesis and the enzymatic conversion of farnesyl to nerolidyl pyrophosphate
    • Cane DE, Iyengar R, Shiao M (1981) Cyclonerodiol biosynthesis and the enzymatic conversion of farnesyl to nerolidyl pyrophosphate. J Amer Chem Soc 103:914-931
    • (1981) J Amer Chem Soc , vol.103 , pp. 914-931
    • Cane, D.E.1    Iyengar, R.2    Shiao, M.3
  • 9
    • 0028908809 scopus 로고
    • Trichodiene synthase. Identification of active site residues by site-directed mutagenesis
    • Cane DE, Shim JH, Xue Q, Fitzsimons C, Hohn TM (1995) Trichodiene synthase. Identification of active site residues by site-directed mutagenesis. Biochemistry 34:2480-2488
    • (1995) Biochemistry , vol.34 , pp. 2480-2488
    • Cane, D.E.1    Shim, J.H.2    Xue, Q.3    Fitzsimons, C.4    Hohn, T.M.5
  • 10
    • 0029797251 scopus 로고    scopus 로고
    • Trichodiene synthase. Probing the role of the highly conserved aspartate-rich region by site-directed mutagenesis
    • Cane DE, Xue Q, Fitzsimons C (1996) Trichodiene synthase. Probing the role of the highly conserved aspartate-rich region by site-directed mutagenesis. Biochemistry 35:12369-12376
    • (1996) Biochemistry , vol.35 , pp. 12369-12376
    • Cane, D.E.1    Xue, Q.2    Fitzsimons, C.3
  • 12
    • 0000488066 scopus 로고
    • Effect of gene disruption of trichodiene synthase (Tox5) on the virulence of Gibberella pulicaris
    • Desjardins AE, Hohn TM, McCormick SP (1992) Effect of gene disruption of trichodiene synthase (Tox5) on the virulence of Gibberella pulicaris. Mol Plant-Microbe Interact 5:214-222
    • (1992) Mol Plant-Microbe Interact , vol.5 , pp. 214-222
    • Desjardins, A.E.1    Hohn, T.M.2    McCormick, S.P.3
  • 13
    • 0027306797 scopus 로고
    • Trichothecene biosynthesis in Fusarium species: Chemistry, genetics, and significance
    • Desjardins AE, Hohn TM, McCormick SP (1993) Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol Rev 57:595-604
    • (1993) Microbiol Rev , vol.57 , pp. 595-604
    • Desjardins, A.E.1    Hohn, T.M.2    McCormick, S.P.3
  • 14
    • 85053318909 scopus 로고
    • Biochemical mechanism of action of trichothecene mycotoxins
    • Beasley VR (ed), CRC Press, Boca Raton
    • Feinberg B, McLaughlin C (1989) Biochemical mechanism of action of trichothecene mycotoxins In: Beasley VR (ed) Trichothecene mycotoxicosis: pathophysiologic effects. CRC Press, Boca Raton, pp 27-36
    • (1989) Trichothecene Mycotoxicosis: Pathophysiologic Effects , pp. 27-36
    • Feinberg, B.1    McLaughlin, C.2
  • 15
    • 0029117636 scopus 로고
    • High frequency occurrence of virus-like particles with double-stranded RNA genome in nontoxigenic strains of Fusarium poae
    • Fekete C, Giczey G, Papp I, Taborhegyi E, Szabo L, Hornok L (1995) High frequency occurrence of virus-like particles with double-stranded RNA genome in nontoxigenic strains of Fusarium poae. FEMS Microbiol Lett 131:295-299
    • (1995) FEMS Microbiol Lett , vol.131 , pp. 295-299
    • Fekete, C.1    Giczey, G.2    Papp, I.3    Taborhegyi, E.4    Szabo, L.5    Hornok, L.6
  • 16
    • 0002949582 scopus 로고
    • The structure and organization of nuclear genes of filamentous fungi
    • Kinghorn JR (ed), IRL Press, Oxford
    • Gurr SJ, Unkles SE, Kinghorn JR (1987) The structure and organization of nuclear genes of filamentous fungi. In: Kinghorn JR (ed) Gene structure in eukaryotic microbes. IRL Press, Oxford, pp 93-139
    • (1987) Gene Structure in Eukaryotic Microbes , pp. 93-139
    • Gurr, S.J.1    Unkles, S.E.2    Kinghorn, J.R.3
  • 17
    • 0024348930 scopus 로고
    • Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichiodes
    • Hohn TM, Beremand PD (1989) Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichiodes. Gene 79:131-138
    • (1989) Gene , vol.79 , pp. 131-138
    • Hohn, T.M.1    Beremand, P.D.2
  • 18
    • 0026867136 scopus 로고
    • Isolation and gene disruption of the Tox5 gene encoding trichodiene synthase in Gibberella pulicaris
    • Hohn TM, Desjardins AE (1992) Isolation and gene disruption of the Tox5 gene encoding trichodiene synthase in Gibberella pulicaris. Mol Plant-Microbe Interact 5:214-222
    • (1992) Mol Plant-Microbe Interact , vol.5 , pp. 214-222
    • Hohn, T.M.1    Desjardins, A.E.2
  • 19
    • 0022964294 scopus 로고
    • Purification and characterization of the sesquiterpene cyclase trichodiene synthase from Fusarium sporotrichioides
    • Hohn TM, VanMiddlesworth F (1986) Purification and characterization of the sesquiterpene cyclase trichodiene synthase from Fusarium sporotrichioides. Arch Biochem Biophys 251:756-761
    • (1986) Arch Biochem Biophys , vol.251 , pp. 756-761
    • Hohn, T.M.1    VanMiddlesworth, F.2
  • 20
    • 0027443846 scopus 로고
    • Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichiodes
    • Hohn TM, McCormick SP, Desjardins AE (1993) Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichiodes. Curr Genet 24:291-295
    • (1993) Curr Genet , vol.24 , pp. 291-295
    • Hohn, T.M.1    McCormick, S.P.2    Desjardins, A.E.3
  • 21
    • 0029131763 scopus 로고
    • The TRI4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis
    • Hohn TM, Desjardins AE, McCormick SP (1995) The TRI4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis. Mol Gen Genet 248:95-102
    • (1995) Mol Gen Genet , vol.248 , pp. 95-102
    • Hohn, T.M.1    Desjardins, A.E.2    McCormick, S.P.3
  • 22
    • 0000485274 scopus 로고
    • Macrocyclic trichothecenes
    • Sharma RP, Salunkhe DK (eds), CRC Press, Boca Raton
    • Jarvis BB (1991) Macrocyclic trichothecenes. In: Sharma RP, Salunkhe DK (eds) Mycotoxins and phytoalexins. CRC Press, Boca Raton, pp 361-421
    • (1991) Mycotoxins and Phytoalexins , pp. 361-421
    • Jarvis, B.B.1
  • 23
    • 2442590270 scopus 로고    scopus 로고
    • Secondary metabolites, complexity, and evolution
    • Romero JT, Saunders J, Barbosa P (eds), Plenum Press, New York
    • Jarvis BB, Miller JD (1996) Secondary metabolites, complexity, and evolution In: Romero JT, Saunders J, Barbosa P (eds) Recent advances in phytochemistry, vol 30 Plenum Press, New York, pp 265-462
    • (1996) Recent Advances in Phytochemistry , vol.30 , pp. 265-462
    • Jarvis, B.B.1    Miller, J.D.2
  • 24
    • 0011737172 scopus 로고
    • Interaction between the antibiotic trichothecenes and the higher plant Baccharis megapotamica
    • Jarvis BB, Midowo JO, Tuthill MB, Bean GA (1981) Interaction between the antibiotic trichothecenes and the higher plant Baccharis megapotamica. Science 214:460-462
    • (1981) Science , vol.214 , pp. 460-462
    • Jarvis, B.B.1    Midowo, J.O.2    Tuthill, M.B.3    Bean, G.A.4
  • 26
    • 0031079973 scopus 로고    scopus 로고
    • Nutrient utilization and natural product gene clusters in filamentous fungi
    • Keller NP, Hohn TM (1997) Nutrient utilization and natural product gene clusters in filamentous fungi. Fungal Genet Biol 21:17-29
    • (1997) Fungal Genet Biol , vol.21 , pp. 17-29
    • Keller, N.P.1    Hohn, T.M.2
  • 27
    • 38249025433 scopus 로고
    • Possible involvement of a pathogen - Produced trichothecene metabolite in Myrothecium leaf spot of muskmelon
    • Kuti JO, Ng TJ, Bean GA (1989) Possible involvement of a pathogen - produced trichothecene metabolite in Myrothecium leaf spot of muskmelon. Physiol Mol Plant Pathol 34:41-54
    • (1989) Physiol Mol Plant Pathol , vol.34 , pp. 41-54
    • Kuti, J.O.1    Ng, T.J.2    Bean, G.A.3
  • 28
    • 0025216801 scopus 로고
    • Bioconversion of possible T-2 toxin precursors by a mutant strain of Fusarium sporotrichioides NRRL 3299
    • McCormick SP, Taylor SL, Plattner RD, Beremand MN (1990) Bioconversion of possible T-2 toxin precursors by a mutant strain of Fusarium sporotrichioides NRRL 3299. Appl Environ Microbiol 56:702-706
    • (1990) Appl Environ Microbiol , vol.56 , pp. 702-706
    • McCormick, S.P.1    Taylor, S.L.2    Plattner, R.D.3    Beremand, M.N.4
  • 29
    • 0030061746 scopus 로고    scopus 로고
    • Isolation and characterization of Tri3, a gene encoding 15-O-acetyltransferase from Fusarium sporotrichioides
    • McCormick SP, Hohn TM, Desjardins AE (1996) Isolation and characterization of Tri3, a gene encoding 15-O-acetyltransferase from Fusarium sporotrichioides. Appl Environ Microbiol 62:353-359
    • (1996) Appl Environ Microbiol , vol.62 , pp. 353-359
    • McCormick, S.P.1    Hohn, T.M.2    Desjardins, A.E.3
  • 32
    • 0021341034 scopus 로고
    • 48. Sambucinol and sambucoin, two new metabolites of Fusarium sambucinum possessing modified trichothecene structures
    • Mohr P, Tamm C, Zurcher W, Zehnder M (1984) 48, Sambucinol and sambucoin, two new metabolites of Fusarium sambucinum possessing modified trichothecene structures. Helvetica Chimica Acta 67:406-412
    • (1984) Helvetica Chimica Acta , vol.67 , pp. 406-412
    • Mohr, P.1    Tamm, C.2    Zurcher, W.3    Zehnder, M.4
  • 33
    • 0023918714 scopus 로고
    • On the membrane topology of vertebrate cytochrome P450 proteins
    • Nelson DR, Strobel HW (1988) On the membrane topology of vertebrate cytochrome P450 proteins. J Biol Chem 263:6038-6050
    • (1988) J Biol Chem , vol.263 , pp. 6038-6050
    • Nelson, D.R.1    Strobel, H.W.2
  • 34
    • 0027413467 scopus 로고
    • Aristolchene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Aril) from Penicillium roqueforti
    • Proctor RH, Hohn TM (1993) Aristolchene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Aril) from Penicillium roqueforti. J Biol Chem 268:4543-4548
    • (1993) J Biol Chem , vol.268 , pp. 4543-4548
    • Proctor, R.H.1    Hohn, T.M.2
  • 35
    • 0029328518 scopus 로고
    • Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene
    • Proctor RH, Hohn TM, McCormick SP (1995a) Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Mol Plant-Microbe Interact 8:593-601
    • (1995) Mol Plant-Microbe Interact , vol.8 , pp. 593-601
    • Proctor, R.H.1    Hohn, T.M.2    McCormick, S.P.3
  • 36
    • 0029063929 scopus 로고
    • TRI6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides
    • Proctor RH, Hohn TM, McCormick SP, Desjardins AE (1995b) TRI6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides. Appl Environ Microbiol 61:1923-1930
    • (1995) Appl Environ Microbiol , vol.61 , pp. 1923-1930
    • Proctor, R.H.1    Hohn, T.M.2    McCormick, S.P.3    Desjardins, A.E.4
  • 37
    • 0030766018 scopus 로고    scopus 로고
    • Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation
    • Proctor RH, Hohn TM, McCormick SP (1997) Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation. Microbiology 143:2583-2591
    • (1997) Microbiology , vol.143 , pp. 2583-2591
    • Proctor, R.H.1    Hohn, T.M.2    McCormick, S.P.3
  • 38
    • 0023529825 scopus 로고
    • Recombinant DNA in filamentous fungi progress and prospects
    • Rambosek JA, Leach J (1987) Recombinant DNA in filamentous fungi progress and prospects. CRC Crit Rev Biotechnol 6:357-393
    • (1987) CRC Crit Rev Biotechnol , vol.6 , pp. 357-393
    • Rambosek, J.A.1    Leach, J.2
  • 39
    • 0030968744 scopus 로고    scopus 로고
    • Macrocyclic trichothecenes in Baccharis coridifolia plants and endophytes and Baccharis artemisiodes plants
    • Rizzo I, Varsavky E, Haidukowski M, Frade H (1997) Macrocyclic trichothecenes in Baccharis coridifolia plants and endophytes and Baccharis artemisiodes plants. Toxicon 35:753-757
    • (1997) Toxicon , vol.35 , pp. 753-757
    • Rizzo, I.1    Varsavky, E.2    Haidukowski, M.3    Frade, H.4
  • 41
    • 0002189846 scopus 로고
    • Trichothecenes
    • Sharma RP, Salunkhe DK (eds), CRC Press, Boca Raton
    • Sharma RP, Kim YW (1991) Trichothecenes In: Sharma RP, Salunkhe DK (eds) Mycotoxins and phytoalexins. CRC Press, Boca Raton, pp 339-359
    • (1991) Mycotoxins and Phytoalexins , pp. 339-359
    • Sharma, R.P.1    Kim, Y.W.2
  • 43
    • 0029039265 scopus 로고
    • Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved in the early aflatoxin pathway
    • Trail F, Mahanti N, Rarick M, Mehigh R, Liang SH, Zhou R, Linz JE (1995) Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved in the early aflatoxin pathway. Appl Environ Microbiol 61:2665-2673
    • (1995) Appl Environ Microbiol , vol.61 , pp. 2665-2673
    • Trail, F.1    Mahanti, N.2    Rarick, M.3    Mehigh, R.4    Liang, S.H.5    Zhou, R.6    Linz, J.E.7
  • 44
    • 0023411338 scopus 로고
    • Development of a fungal transformation system based on selection of sequences with promoter activity
    • Turgeon GB, Gaber RC, Yoder OC (1987) Development of a fungal transformation system based on selection of sequences with promoter activity. Mol Cell Biol 17:3297-3305
    • (1987) Mol Cell Biol , vol.17 , pp. 3297-3305
    • Turgeon, G.B.1    Gaber, R.C.2    Yoder, O.C.3
  • 45
    • 0002743295 scopus 로고
    • Gene organization in filamentous fungi
    • Broda PMA, Oliver SG, Sims PFG (eds), Cambridge University Press
    • Turner G (1993) Gene organization in filamentous fungi. In: Broda PMA, Oliver SG, Sims PFG (eds) The eukaryotic genome: organization and regulation. Cambridge University Press, pp 107-125
    • (1993) The Eukaryotic Genome: Organization and Regulation , pp. 107-125
    • Turner, G.1
  • 47
    • 0029931405 scopus 로고    scopus 로고
    • Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus
    • Yu JH, Butchko RAE, Fernandes M, Keller NP, Leonard TJ, Adams TH (1996) Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr Genetics 29:549-555
    • (1996) Curr Genetics , vol.29 , pp. 549-555
    • Yu, J.H.1    Butchko, R.A.E.2    Fernandes, M.3    Keller, N.P.4    Leonard, T.J.5    Adams, T.H.6
  • 48
    • 0000819605 scopus 로고
    • Trichothecene mycotoxins: Mycology, chemistry, toxicology
    • Ueno Y (1980) Trichothecene mycotoxins: mycology, chemistry, toxicology. Adv Nutr Sci 3:301-353
    • (1980) Adv Nutr Sci , vol.3 , pp. 301-353
    • Ueno, Y.1
  • 49
    • 0016760624 scopus 로고
    • Production of trichothecene mycotoxins by Fusarium species in liquid shake culture
    • Ueno Y, Sawano M, Ishii K (1975) Production of trichothecene mycotoxins by Fusarium species in liquid shake culture. Appl Microbiology 30:4-9
    • (1975) Appl Microbiology , vol.30 , pp. 4-9
    • Ueno, Y.1    Sawano, M.2    Ishii, K.3


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