Relationships between cell survival and specific energy spectra for therapeutic alpha-particle emitters

Radiation Research

Volumn 145, Issue 3, 1996, Pages 268-273

  Roeske, John C ^a   Stinchcomb, Thomas G ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b DEPAUL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RADIATION; ARTICLE; CELL NUCLEUS; CELL SIZE; CELL SURVIVAL; LINEAR ENERGY TRANSFER; MATHEMATICAL ANALYSIS; MICRODOSIMETRY; PRIORITY JOURNAL; RADIATION FIELD; RADIATION RESPONSE; RADIOSENSITIVITY;

EID: 0029938047     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3578981     Document Type: Article

References (20)

1. J. Rotmensch, R. W. Atcher, J. Hines, D. Grdina, J. S. Schwarte, M. Toohill and A. Herbst, The development of α-emitting radionuclide lead 212 for the potential treatment of ovarian carcinoma. Am. J. Obstet. Gynecol. 160, 789-797 (1989).
2. J. Rotmensch, R. W. Atcher, R. Schlenker, J. Hines, D. Grdina, B. S. Block, M. Press, A. Herbst and R. R. Weichselbaum, The effect of α-emitting radionuclide lead 212 on human ovarian carcinoma: A potential new form of therapy. Gynecol Oncol 32, 236-239 (1989).
3. J. Rotmensch, R. W. Atcher, J. Hines, M. Toohill and A. L. Herbst, Comparison of short-lived high-LET α-emitting radionuclide lead-212 and bismuth-212 to low-LET x-rays on ovarian carcinoma. Gynecol. Oncol. 35, 297-300 (1989).
4. R. M. Macklis, W. D. Kaplan, J. L. M. Ferrara, R. W. Atcher, J. J. Hines, S. J. Burahoff and C. N. Coleman, Alpha particle radioimmunotherapy: Animal models and clinical perspectives. Int. J. Radiat. Oncol. Biol. Phys. 16, 1377-1387 (1988).
5. R. M. Macklis, B. M. Kinsey, A. I. Kassis, J. L. M. Ferrara, R. W. Atcher, J. J. Hines, C. N. Coleman, S. J. Adelstein and S. J. Burakoff, Radioimmunotherapy with alpha-particle-emitting immunoconjugates. Science 240, 1024-1026 (1988).
6. R. W. Kozak, R. W. Atcher, O. A. Gansow, A. M. Friedman, J. J. Hines and T. A. Waldman, Bismuth-212-labeled anti-TAC monoclonal antibody: α-Particle-emitting radionuclides as modalities for radioimmunotherapy. Proc Natl. Acad. Sci. USA 83, 474-478 (1986).
7. 212Bismuth linked to an antipancreatic carcinoma antibody: Model for alpha-particle-emitter radioimmunotherapy. J. Natl. Cancer Inst. 80, 449-452 (1988).
8. E. J. Hall, Radiobiology for the Radiologist, 2nd ed. Harper and Row, Hagerstown, MD, 1978.
9. E. Polig, Localized alpha-dosimetry. In Current Topics in Radiation Research (M. Ebert and A. Howard, Eds.), Vol. 13, pp. 189-327. North Holland, Amsterdam, 1978.
10. D. E. Charlton and R. A. Sephton, A relationship between microdosimetric spectra and cell survival for high-LET irradiation. Int. J. Radiol. Biol. 59, 447-457 (1991).
11. J. L. Humm and L. M. Chin, A model of cell inactivation by alpha-particle internal emitters. Radiat. Res. 134, 143-150 (1993).
12. T. G. Stinchcomb and J. C. Roeske, Analysis of survival of C-18 cells after irradiation in suspension with chelated and ionic bismuth-212 using microdosimetry. Radiat. Res. 140, 48-54 (1994).
13. T. G. Stinchcomb and J. C. Roeske. Analytic microdosimetry for radioimmunotherapeutic alpha emitters. Med. Phys. 19, 1385-1393 (1992).
14. K. F. Eckerman, J. C. Ryman, A. C. Taner and G. D. Kerr, Traversais of cells by radiation and absorbed fraction estimates for electrons and alpha particles. In Proceedings of the Fourth International Radiopharmaceutical Dosimetry Symposium (A. T. Schlafke-Stelson and E. E. Watson, Eds.), pp. 67-86, CONF-851113, Oak Ridge Associated Universities, Oak Ridge, TN, 1986.
15. T. G. Stinchcomb and J. C. Roeske, Survival of alpha-particle irradiated cells versus the shape and size of the sensitive volume (nucleus). Radiat. Prot. Dosim., in press.
16. R. W. Howell, D. V. Rao, D-Y. Hou, V. R. Narra and K. S. Sastry, The question of relative biological effectiveness and quality factor for Auger emitters incorporated into proliferating mammalian cells. Radiat. Res. 128, 282-292 (1991).
17. J. L. Schwartz, J. D. Shadley, R. W. Atcher, J. Tang, J. L. Whitlock and J. Rotmensch, Comparison of radon-daughter-induced effects in repair-proficient and repair-deficient CHO cell lines. Environ. Mol. Mutagen. 16, 178-184 (1990).
18. J. D. Shadley, J. L. Whitlock, J. Rotmensch, R. W. Atcher, J. Tang and J. L. Schwartz, The effects of radon daughter α-particle irradiation in K1 and XRS-5 CHO cell lines. Mutat. Res. 248, 73-83 (1991).
19. R. F. Jostes, T. E. Hui, A. C. Janes, F. T. Cross, J. L. Schwartz, J. Rotmensch, R. W. Atcher, H. H. Evans, J. Mencl, G. Bakale and P. S. Rao, In vitro exposure of mammalian cells to radon: Dosimetric considerations. Radiat. Res. 127, 211-219 (1991).
20. J. L. Humm, J. C. Roeske, D. R. Fisher and G. T. Y. Chen, Microdosimetric concepts in radioimmunotherapy. Med. Phys. 20, 535-541 (1993).