Restriction of the TCR repertoire inhibits the development of memory T cells and prevents autoimmunity in lpr mice

Journal of Immunology

Volumn 156, Issue 12, 1996, Pages 4961-4968

  Perkins, D L ^a   Listman, J A ^b   Marshak Rothstein, A ^d   Kozlow, W ^c   Kelley, V R ^a   Finn, P W ^c   Rimm, I J ^d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; GENE MUTATION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; GENE REARRANGEMENT, T-LYMPHOCYTE; IMMUNOLOGIC MEMORY; LYMPHOCYTE SUBSETS; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RHEUMATOID FACTOR; SURVIVAL ANALYSIS;

EID: 0030002562     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Murphy, E. D. 1981. Lymphoproliferation (lpr) and other single-locus models for murine lupus. Immunological Defects in Laboratory Animals 2:143.
2. Theofilopoulos, A. N., and F. J. Dixon. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:269.
3. Cohen, P. L., and R. A. Eisenberg. 1991. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
4. Steinberg, A. D. 1994. MRL-lpr/lpr disease: theories meet Fas. Semin. Immunol. 6:55.
5. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. Wilson, B. McConahey, P. J. Murphy, E. D. Roths, and J. F. Dixon. 1978. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
6. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
7. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233.
8. Singer, G. G., A. C. Carrera, A. Marshak-Rothstein, C. Martinez, and A. K. Abbas. 1994. Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model. Curr. Opin. Immunol. 6:913.
9. Theofilopoulos, A. N., R. S. Balderas, R. Baccala, and D. H. Kono. 1993. T cell receptor genes in autoimmunity. Ann. NY Acad. Sci. 21:33.
10. Sidman, C. L., J. D. Marshall, and H. vonBoehmer. 1992. Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice, Eur. J. Immunol. 22:499.
11. Herron, L. R., R. A. Eisenberg, R. E. Roper, V. N. Kakkanaiah, P. L. Cohen, and B. L. Kotzin. 1993. Selection of the T cell receptor repertoire in lpr mice. J. Immunol. 151:3410.
12. Alderson, M. R., J. J. Armitage, E. Maraskovsky, T. W. Tough, J. Roux, K. Schooley, R. Ramsdell, and D. H. Lynch. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231.
13. + T cells in lpr/lpr mice. J. Exp. Med. 172:1805.
14. Listman, J. A., I. J. Rimm, Y. Wang, M. Geller, J. C. Tang, S. Ho, P. W. Finn, and D. L. Perkins. 1996. Plasticity of the T cell receptor repertoire in TCR β-chain transgenic mice. Cell. Immunol. 167:44.
15. Fenton, R. G., P. Marrack, J. W. Kappler, O. Kanagawa, and J. G. Seidman. 1988. Isotypic exclusion of gamma-delta T cell receptors in transgenic mice bearing a rearranged beta-chain gene. Science 241:1089.
16. Perkins, D. L., Y. Wang, D. Fruman, J. G. Seidman, and I. J. Rimm. 1991. Immunodominance is altered in T cell receptor (β-chain) transgenic mice without the generation of a hole in the repertoire. J. Immunol. 146:2960.
17. Perkins, D. L., J. Michaelson, and A. Marshak-Rothstein. 1987. The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice. J. Immunol. 138:466.
18. Dialynas, D., Z. Quan, K. Wall, A. Pierres, J. Quintans, M. Loken, M. Pierres, and F. Fitch. 1983. Characterization of the murine T cell surfact molecule designated L3T4, identified by monoclonal antibody GK-1.5: similarity of L3T4 to the human Leu3/T4 molecule and the possible involvement of L3T4 in class II MHC antigen reactivity. J. Immunol. 133:2445.
19. Ledbetter, J., and L. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47:63.
20. Trowbridge, I. S., J. Lesley, R. Schulte, R. Hyman, and J. Troller. 1982. Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed in lymphoid tissues. Immunogenetics 15:299.
21. Staerz, U., H. G. Rammensee, J. D. Benedetto, and M. J. Bevan. 1985. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J. Immunul. 134:3994.
22. Coligan, J. E., A. M. Kruisbeek, D. H. Marguilies, E. M. Shevach, and W. Strober. 1991. Current Protocols in Immunology. J. E. Coligan, ed. John Wiley and Sons, Inc., New York.
23. Jevnikar, A. M., M. J. Grusby, and L. H. Glimcher. 1994. Prevention of nephritis in major histocompatibility complex class II-deficient MKL-lpr mice. J. Exp. Med. 179:1137.
24. 2-microglobulin. J. Immunol. 154:2063.
25. Giese, T., and W. F. Davidson. 1994. Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production. J. Immunol. 152: 2000.
26. Jabs, D. A., R. C. Kuppers, A. M. Saboori, C. L. Burek, C. Enger, B. Lee, and R. A. Prendergast. 1994. Effects of early and late treatment with anti-CD4 monoclonal antibody on autoimmune disease in MRL/MP-lpr/lpr mice. Cell. Immunol. 154:66.
27. Perkins, D. L., R. M. Glaser, C. A. Mahon, J. Michaelson, and A. Marshak-Rothstein. 1990. Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras. J. Immunol. 145:549.
28. Katagiri, T., P. L. Cohen, and R. A. Eisenberg. 1988. The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation. J. Exp. Med. 167:741.
29. Sobel, E. S., T. Katyagari, K. Katagari, S. C. Morris, P. L. Cohen, and R. A. Eisenberg. 1991. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J. Exp. Med. 173:1441.
30. Nemazee, D., C. Guiet, K. Buerki, and A. Marshak-Rothstein. 1991. B lymphocytes from autoimmune-prone mouse strain MRL/lpr manifest an intrinsic defect in tetraparental MRL/lpr X DBA/2 chimeras. J. Immunol. 147:2536.
31. cg, that complements the gld gene in induction of lymphadenopathy in the mouse. J. Exp. Med. 171:519.
32. Nagata, S. 1994. Mutations in the Fas antigen gene in lpr mice. Semin. Immunol. 6:3.
33. Shores, E. W., J. A. Eisenberg, and P. L. Cohen. 1988. T-B collaboration in the in vitro anti-Sm autoantibody response of MRL/Mp-lpr/lpr mice. J. Immunol. 140:2977.
34. Sobel, E. S., V. N. Kakkanaiah, M. Kakkanaiah, R. L. Cheek, P. L. Cohen, and R. A. Eisenberg. 1994. T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted. J. Immunol. 152:6011.
35. + T cells. Nature 376:181.
36. Russell, J. H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA 90:4409.
37. + T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151:7233.
38. Shan, H., M. J. Shlomchik, A. Marshak-Rothstein, D. S. Pisetsky, S. Litwin, and M. G. Weigert. 1994. The mechanisms of autoantibody production in an autoimmune MRL/lpr mouse. J. Immunol. 153:5104.
39. Schlomchik, M., M. Mascelli, H. Shan, M. Z. Radic, D. Pisetsky, A. Marshak-Rothstein, and M. Weigert. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265.
40. Giese, J., and W. F. Davidson. 1992. Evidence for early onset polyclonal activation of T cell subsets in mice homozygous for lpr. J. Immunol. 149:3097.
41. Davidson, W. F., C. Calkins, A. Hugin, T. Giese, and K. L. Holmes. 1991. Cytokine secretion by C3H-lpr and -gld T cells. J. Immunol. 146:4138.
42. Budd, R. C., H. H. Schumacher, G. Winslow, and T. R. Mosmann. 1991. Elevated production of interferon-gamma and interleukin 4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 (CD44) expression. Eur. J. Immunol. 21:1081.
43. Mountz, J. D., H. Bluethmann, T. Zhou, and J. Wu. 1994. Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice. Semin. Immunol. 6:27.
44. Singer, P. A., and A. N. Theofilopoulos. 1990. Novel origin of lpr and gld cells and possible implications in autoimmunity. J. Autoimmun. 3:123.
45. Cerrotini, J. C., and H. R. MacDonald. 1989. The cellular basis of T-cell memory. Annu. Rev. Immunol. 7:77.
46. Lee, W. T., and E. S. Vitetta. 1991. The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse. Cell. Immunol. 132:215.
47. Swain, S. L., and L. M. Bradley. 1992. Helper T cell memory: more questions than answers. Semin. Immunol. 4:59.
48. Gray, D. 1993. Immunological memory. Annu. Rev. Immunol. 11:49.
49. Sprent, J., and D. F. Tough. 1994. Lymphocyte life-span and memory. Science 265:1395.