메뉴 건너뛰기




Volumn 111, Issue 2, 1998, Pages 327-332

Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: Implications for the treatment of cutaneous lymphoprohferatlve and inflammatory disorders

Author keywords

Apoptosis; CTCL; Photoactivation

Indexed keywords

HYPERICIN; METHOXSALEN;

EID: 0031903830     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00278.x     Document Type: Article
Times cited : (71)

References (48)
  • 3
    • 0028154811 scopus 로고
    • Inhibition of MAO by fraction and constituents of hypericum extract
    • Bladt S, Wagner H: Inhibition of MAO by fraction and constituents of hypericum extract. J Geriatric Psychiatry Neurol 7 (Suppl. 1):S57-S59, 1994
    • (1994) J Geriatric Psychiatry Neurol , vol.7 , Issue.1 SUPPL.
    • Bladt, S.1    Wagner, H.2
  • 4
    • 0026113374 scopus 로고
    • Photosensitization is required for inactivation of equine infectious anemia virus by hyperium
    • Carpenter S, Kraus GA: Photosensitization is required for inactivation of equine infectious anemia virus by hyperium. Photochem Photobiol 53:169-174, 1991
    • (1991) Photochem Photobiol , vol.53 , pp. 169-174
    • Carpenter, S.1    Kraus, G.A.2
  • 5
    • 0027988475 scopus 로고
    • Chemiluminescent activation of the antiviral activity of hypericin: A molecular flashlight
    • Carpenter S, Fehr MJ, Kraus GA, Petrich JW: Chemiluminescent activation of the antiviral activity of hypericin: a molecular flashlight. Proc Natl Acad Sci USA 91:12273-12277, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12273-12277
    • Carpenter, S.1    Fehr, M.J.2    Kraus, G.A.3    Petrich, J.W.4
  • 6
    • 0027939352 scopus 로고
    • Hypericin uptake in rabbits and nude mice transplanted with human squamous cell carcinomas: Study of a new sensitizer for laser phototherapy
    • Chung PS, Saxton RE, Paiva MB, et al: Hypericin uptake in rabbits and nude mice transplanted with human squamous cell carcinomas: study of a new sensitizer for laser phototherapy. Laryngoscope 104:1471-1476, 1994
    • (1994) Laryngoscope , vol.104 , pp. 1471-1476
    • Chung, P.S.1    Saxton, R.E.2    Paiva, M.B.3
  • 8
    • 0029319635 scopus 로고
    • Novel therapeutic and diagnostic applications of hypocrellins and hypericins
    • Diwu Z: Novel therapeutic and diagnostic applications of hypocrellins and hypericins. Photochem Photobiol 61:529-539, 1995
    • (1995) Photochem Photobiol , vol.61 , pp. 529-539
    • Diwu, Z.1
  • 9
    • 0027391090 scopus 로고
    • Photosensitization with anticancer agents 17: The EPR study of photodynamic action of hypericin
    • Diwu Z, Lown JW: Photosensitization with anticancer agents 17: The EPR study of photodynamic action of hypericin. Free Rad Biol Med 14:209-215, 1993
    • (1993) Free Rad Biol Med , vol.14 , pp. 209-215
    • Diwu, Z.1    Lown, J.W.2
  • 10
    • 0029666161 scopus 로고    scopus 로고
    • Sezary syndrome T cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon gamma receptor beta-chain)
    • Dummer R, Heald PW, Nestle FO, Ludwig E, Laine E, Hemmi S, Burg G: Sezary syndrome T cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon gamma receptor beta-chain). Blood 88:1383-1389, 1996
    • (1996) Blood , vol.88 , pp. 1383-1389
    • Dummer, R.1    Heald, P.W.2    Nestle, F.O.3    Ludwig, E.4    Laine, E.5    Hemmi, S.6    Burg, G.7
  • 11
    • 0022730534 scopus 로고
    • Hyperium and its photodynamic action
    • Duran N, Song PS: Hyperium and its photodynamic action. Photochem Photobiol 43:677-680, 1986
    • (1986) Photochem Photobiol , vol.43 , pp. 677-680
    • Duran, N.1    Song, P.S.2
  • 12
    • 0030220463 scopus 로고    scopus 로고
    • Photodynamic effects of hypertein on lipid peroxidation and antioxidant status in melonoma cells
    • Hadjur C, Richard MJ, Parat MO, Jardon P, Favier A: Photodynamic effects of hypertein on lipid peroxidation and antioxidant status in melonoma cells. Photochem Photobiol 64:375-381, 1996
    • (1996) Photochem Photobiol , vol.64 , pp. 375-381
    • Hadjur, C.1    Richard, M.J.2    Parat, M.O.3    Jardon, P.4    Favier, A.5
  • 13
    • 0030036743 scopus 로고    scopus 로고
    • Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: Potential therapeutic application
    • Hamilton HB, Hinton DR, Law RE, et al: Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurgery 85:329-334, 1996
    • (1996) J Neurosurgery , vol.85 , pp. 329-334
    • Hamilton, H.B.1    Hinton, D.R.2    Law, R.E.3
  • 15
    • 0028316195 scopus 로고
    • Induction of apoptotic DNA fragmentation and cell death in HI-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C
    • Jarvis WD, Turner AJ, Povirk TF, Travlor RS, Grant S: Induction of apoptotic DNA fragmentation and cell death in HI-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54:1707-1714, 1994
    • (1994) Cancer Res , vol.54 , pp. 1707-1714
    • Jarvis, W.D.1    Turner, A.J.2    Povirk, T.F.3    Travlor, R.S.4    Grant, S.5
  • 19
    • 0024439459 scopus 로고
    • Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin
    • Lavie G, Valentine F, Levin B, et al: Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc Natl Acad Sci USA 86:5963-5967, 1989
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5963-5967
    • Lavie, G.1    Valentine, F.2    Levin, B.3
  • 20
    • 0028883308 scopus 로고
    • The chemical and biological properties of hypericin - A compound with a broad spectrum of biological activities
    • published erratum appears in Med Res Rev 15:259, 1995
    • Lavie G, Mazur Y, Lavie D, Meruelo D: The chemical and biological properties of hypericin - a compound with a broad spectrum of biological activities [published erratum appears in Med Res Rev 15:259, 1995]. Med Res Rev 15:111-119, 1995
    • (1995) Med Res Rev , vol.15 , pp. 111-119
    • Lavie, G.1    Mazur, Y.2    Lavie, D.3    Meruelo, D.4
  • 21
    • 0027389005 scopus 로고
    • Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: Inhibition of fusion and syncytia formation
    • Lenard J, Rabson A, Vanderoef R: Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci USA 90:158-162, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 158-162
    • Lenard, J.1    Rabson, A.2    Vanderoef, R.3
  • 22
    • 0025805412 scopus 로고
    • Molecular diagnosis of cutaneous T cell lymphoma: Polymerase chain reaction amplification of T cell antigen receptor beta-chain gene rearrangements
    • Lessin SR, Rook AH, Rovera G: Molecular diagnosis of cutaneous T cell lymphoma: polymerase chain reaction amplification of T cell antigen receptor beta-chain gene rearrangements. J Invest Dermatol 96:299-302, 1991
    • (1991) J Invest Dermatol , vol.96 , pp. 299-302
    • Lessin, S.R.1    Rook, A.H.2    Rovera, G.3
  • 23
    • 0025769619 scopus 로고
    • A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography
    • Laebes I, Mazur Y, Freeman D, et al: A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography. Anal Biochem 195:77-86, 1991
    • (1991) Anal Biochem , vol.195 , pp. 77-86
    • Laebes, I.1    Mazur, Y.2    Freeman, D.3
  • 25
    • 0040805180 scopus 로고
    • Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin
    • Meruelo D, Lavie G, Lavie D: Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc Natl Acad Sci USA 85:5230-5234, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5230-5234
    • Meruelo, D.1    Lavie, G.2    Lavie, D.3
  • 27
    • 0028793881 scopus 로고
    • Pharmacological profile of hypericum extract Effect on serotonin uptake by postsynaptic receptors
    • Perovic S, Muller WE: Pharmacological profile of hypericum extract Effect on serotonin uptake by postsynaptic receptors. Arzneumittel-Forschung 45, 1145-1148, 1995
    • (1995) Arzneumittel-Forschung , vol.45 , pp. 1145-1148
    • Perovic, S.1    Muller, W.E.2
  • 28
    • 0027475089 scopus 로고
    • Immunopathogenesis of cutaneous T cell lymphomas: Abnormal cytokine production by Sczary T cells
    • Rook AH, Lessin SR, Jaworsky C, Singh A, Vowels BR: Immunopathogenesis of cutaneous T cell lymphomas: Abnormal cytokine production by Sczary T cells. Arch Dermatol 129:486-489, 1993.
    • (1993) Arch Dermatol , vol.129 , pp. 486-489
    • Rook, A.H.1    Lessin, S.R.2    Jaworsky, C.3    Singh, A.4    Vowels, B.R.5
  • 29
    • 0028797606 scopus 로고
    • 11-12 reverses cytokine and immune abnormalities in Sczary syndrome
    • Rook AH, Kubin M, Cassin M, et al: 11-12 reverses cytokine and immune abnormalities in Sczary syndrome. J Immunol 154:1491-1498, 1995
    • (1995) J Immunol , vol.154 , pp. 1491-1498
    • Rook, A.H.1    Kubin, M.2    Cassin, M.3
  • 31
    • 0027946782 scopus 로고
    • Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract 11 160 an healthy volunteers
    • Staffeldt B, Kerb R, Brockmoller J, Ploch M, Roots I: Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract 11 160 an healthy volunteers. J Geriatrn Psychiatry Neurol 7 (Suppl. 1):S47-S53, 1994
    • (1994) J Geriatrn Psychiatry Neurol 7 , Issue.1 SUPPL.
    • Staffeldt, B.1    Kerb, R.2    Brockmoller, J.3    Ploch, M.4    Roots, I.5
  • 32
    • 0030896996 scopus 로고    scopus 로고
    • Malignant melanoma in patients treated for psortasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA)
    • Stern RS, Nichols KT, Vakeva TH: Malignant melanoma in patients treated for psortasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). New England J Med 336:1041-1045, 1997
    • (1997) New England J Med , vol.336 , pp. 1041-1045
    • Stern, R.S.1    Nichols, K.T.2    Vakeva, T.H.3
  • 33
    • 0024847267 scopus 로고
    • Hypericin and pseudohypericin specifically inhibit protein kinase C. possible relation to their antiretroviral activity
    • Takahashi I, Nakanishi S, Kobayashi E, Nakano H, Suzuki K, Tamaoki T: Hypericin and pseudohypericin specifically inhibit protein kinase C. possible relation to their antiretroviral activity. Biochem Biophys Res Comms 165:1207-1212, 1989
    • (1989) Biochem Biophys Res Comms , vol.165 , pp. 1207-1212
    • Takahashi, I.1    Nakanishi, S.2    Kobayashi, E.3    Nakano, H.4    Suzuki, K.5    Tamaoki, T.6
  • 34
    • 0025301161 scopus 로고
    • Viruental activity of hypericin against enveloped and non enveloped DNA and RNA viruses
    • Tang J, Colacino JM, Larsen SH, Spitzer W: Viruental activity of hypericin against enveloped and non enveloped DNA and RNA viruses. Antiviral Res 13:313-325, 1990
    • (1990) Antiviral Res , vol.13 , pp. 313-325
    • Tang, J.1    Colacino, J.M.2    Larsen, S.H.3    Spitzer, W.4
  • 35
    • 0026873378 scopus 로고
    • Oxygen dependence of hypericin induced phototoxicity to EMT6 mouse mammary carcinoma cells
    • Thomas C, Pardini RS: Oxygen dependence of hypericin induced phototoxicity to EMT6 mouse mammary carcinoma cells. Photochem Photobiol 55:831-837, 1992
    • (1992) Photochem Photobiol , vol.55 , pp. 831-837
    • Thomas, C.1    Pardini, R.S.2
  • 36
    • 0026467668 scopus 로고
    • Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succmoxidase
    • Thomas C, MacGill RS, Miller GC, Pardini RS: Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succmoxidase. Photochem Photobiol 55:47-53, 1992
    • (1992) Photochem Photobiol , vol.55 , pp. 47-53
    • Thomas, C.1    MacGill, R.S.2    Miller, G.C.3    Pardini, R.S.4
  • 37
    • 0028890257 scopus 로고
    • Light dependent inhibition of protein kinase C and superoxide generation of neutrophils by hypericin, an antiretroviral agent
    • Utsumi T, Okuma M, Kanno T, Yasuda T, Kobuchi H, Horton AA, Utsumi K: Light dependent inhibition of protein kinase C and superoxide generation of neutrophils by hypericin, an antiretroviral agent. Arch Biochem Biophysics 316:493-497, 1995
    • (1995) Arch Biochem Biophysics , vol.316 , pp. 493-497
    • Utsumi, T.1    Okuma, M.2    Kanno, T.3    Yasuda, T.4    Kobuchi, H.5    Horton, A.A.6    Utsumi, K.7
  • 38
    • 0031040341 scopus 로고    scopus 로고
    • Multiple squamous cell carcinoma in a psoriatic patient following high dose photochemotherapy and cyclosporin treatment: Responce to long-term acitretin maintanance
    • Van de Kerkhof PC, de Rooij MJ: Multiple squamous cell carcinoma in a psoriatic patient following high dose photochemotherapy and cyclosporin treatment: responce to long-term acitretin maintanance. Br J Dermatol 136:275-278, 1997
    • (1997) Br J Dermatol , vol.136 , pp. 275-278
    • Van De Kerkhof, P.C.1    De Rooij, M.J.2
  • 39
    • 0344091631 scopus 로고    scopus 로고
    • Hypericin: A new laser phototargeting agent for human cancer cells
    • VanderWerf OM, Saxton RE, Chang A, et al: Hypericin: a new laser phototargeting agent for human cancer cells. Laryngoscope 106:479-483, 1996
    • (1996) Laryngoscope , vol.106 , pp. 479-483
    • Vanderwerf, O.M.1    Saxton, R.E.2    Chang, A.3
  • 40
    • 0031196932 scopus 로고    scopus 로고
    • An unexpected spectrum of p53 mutations from squamous cell carcinomas in psoriasis patients treated with PUVA
    • Wang XM, McNiff JM, Klump V, Asgata M, Gasparto FP: An unexpected spectrum of p53 mutations from squamous cell carcinomas in psoriasis patients treated with PUVA. Photochem Photobiol 66:294-299, 1997
    • (1997) Photochem Photobiol , vol.66 , pp. 294-299
    • Wang, X.M.1    McNiff, J.M.2    Klump, V.3    Asgata, M.4    Gasparto, F.P.5
  • 42
    • 0024523601 scopus 로고
    • Detection of clonal T cell receptor gene rearrangements in the peripheral blood of patients with mycosis fungoidez: Sezary syndrome
    • Weiss LM, Wood GS, Hu E, Abel EA, Hoppe RT, Sklar J: Detection of clonal T cell receptor gene rearrangements in the peripheral blood of patients with mycosis fungoidez: Sezary syndrome. J Invest Dermatol 92:601-604, 1989
    • (1989) J Invest Dermatol , vol.92 , pp. 601-604
    • Weiss, L.M.1    Wood, G.S.2    Hu, E.3    Abel, E.A.4    Hoppe, R.T.5    Sklar, J.6
  • 43
    • 0026355129 scopus 로고
    • Analysis of beta, gamma, and delta T cell receptor genes in mycosis fungoides and Sezary syndrome
    • Whittaker SJ, Smith NP, Jones RR, Luzzatto I: Analysis of beta, gamma, and delta T cell receptor genes in mycosis fungoides and Sezary syndrome. Cancer 68:1572-1582, 1991
    • (1991) Cancer , vol.68 , pp. 1572-1582
    • Whittaker, S.J.1    Smith, N.P.2    Jones, R.R.3    Luzzatto, I.4
  • 45
    • 0028923278 scopus 로고
    • Analysis of T cell receptor beta-chain genes by Southern blotting in known and suspected cutaneous T cell lymphomas. A study of 67 samples from 32 patients
    • Wolff-Sneedorff A, Ralfkiaer E, Thomsen K, Vejlsgaard GI: Analysis of T cell receptor beta-chain genes by Southern blotting in known and suspected cutaneous T cell lymphomas. A study of 67 samples from 32 patients. Clin Exp Dermatol 20:115-122. 1995
    • (1995) Clin Exp Dermatol , vol.20 , pp. 115-122
    • Wolff-Sneedorff, A.1    Ralfkiaer, E.2    Thomsen, K.3    Vejlsgaard, G.I.4
  • 46
    • 0026003311 scopus 로고
    • T cell receptor gene rearrangement analysis: Cutaneous T cell lymphoma, peripheral T cell lymphoma, and premalignant and benign cutaneous lymphoproliferative disorders
    • Zelickson BD, Peters MS, Muller SA, Thibodeau SN, Lust JA, Quam LM, Pittelkow MR: T cell receptor gene rearrangement analysis: cutaneous T cell lymphoma, peripheral T cell lymphoma, and premalignant and benign cutaneous lymphoproliferative disorders. J Am Acad Dermatol 25:787-796, 1991
    • (1991) J Am Acad Dermatol , vol.25 , pp. 787-796
    • Zelickson, B.D.1    Peters, M.S.2    Muller, S.A.3    Thibodeau, S.N.4    Lust, J.A.5    Quam, L.M.6    Pittelkow, M.R.7
  • 47
    • 0029102788 scopus 로고
    • Growth inhibition and apoptosis in human neuroblastoma SK N-SH cells induced by hypericin, a potent inhibitor of protein kinase C
    • Zhang W, Lawa RE, Hintona DR, Su Y, Couldwell WT: Growth inhibition and apoptosis in human neuroblastoma SK N-SH cells induced by hypericin, a potent inhibitor of protein kinase C. Cancer Lett 96:31-35, 1995
    • (1995) Cancer Lett , vol.96 , pp. 31-35
    • Zhang, W.1    Lawa, R.E.2    Hintona, D.R.3    Su, Y.4    Couldwell, W.T.5
  • 48
    • 0030025152 scopus 로고    scopus 로고
    • Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: Corroborating clinical responce in vitro: case report
    • Zhang W, Hinton DR, Surnock AA, Couldwell WT: Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical responce in vitro: case report. Neurosurgery 38:587-591, 1996.
    • (1996) Neurosurgery , vol.38 , pp. 587-591
    • Zhang, W.1    Hinton, D.R.2    Surnock, A.A.3    Couldwell, W.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.