An Unexpected Spectrum of p53 Mutations from Squamous Cell Carcinomas in Psoriasis Patients Treated with PUVA

Photochemistry and Photobiology

Volumn 66, Issue 2, 1997, Pages 294-299

  Wang, Xiao Mei ^a   McNiff, Jennifer Madison ^b   Klump, Vincent ^b   Asgari, Maryam ^b   Gasparro, Francis P ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL; ARTICLE; GENETICS; HUMAN; MOUSE; MUTATION; POLYMERASE CHAIN REACTION; PSORIASIS; PUVA; SINGLE STRAND CONFORMATION POLYMORPHISM; SQUAMOUS CELL CARCINOMA;

ANIMALS; CARCINOMA, SQUAMOUS CELL; HUMANS; MICE; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PSORIASIS; PUVA THERAPY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031196932     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb08658.x     Document Type: Article

References (26)

1. Parrish, J. A., T. B. Fitzpatrick, L. Tannenbaum and M. A. Pathak (1974) Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light. N. Engl. J. Med. 291, 1207-1211.
2. Honigsmann, H., K. Wolff, T. B. Fitzpatrick, M. A. Pathak and J. A. Parrish (1987) Oral photochemotherapy with psoralen and UVA (PUVA): principles and practice. In Dermatology in General Medicine (Edited by T. B. Fitzpatrick, A. Z. Eisen, K. Wolff, I. M. Freedberg and K. F. Austen), McGraw-Hill, pp. 1533-1558, New York.
3. Edelson, R. L. , C. L. Berger, F. P. Gasparro and Members of the Extracorporeal Photochemotherapy Study Group (1987) Treatment of cutaneous T cell lymphoma by extracorporeal photochemotherapy. N. Engl. J. Med. 316, 297-303.
4. Stern, R. S. , N. Laird and Members of the Photochemotherapy Follow-up Study (1994) The carcinogenic risk of treatments for severe psoriasis. Cancer 73, 2759-2764.
5. Studniberg, H. M. and P. Weller (1993) PUVA, UVB, psoriasis and nonmelanoma cancer. J. Am. Acad. Dermatol. 29, 1013-1022.
6. Yang, X. Y. , F. P. Gasparro, V. A. DeLeo and R. M. Santella (1989) 8-Methoxypsoralen-DNA photoadducts in patients treated with 8-methoxypsoralen and ultraviolet A light. J. Invest. Dermatol. 92, 59-63.
7. Burger, P. M. and J. W. I. M. Simons (1979) Mutagenicity of 8-methoxypsoralen and long-wave ultraviolet irradiation in haploid human skin fibroblasts: an improved risk estimate in photochemotherapy. Mutat. Res. 63, 371-380.
8. Strauss, G. H. , R. J. Albertini, P. A. Krusinski and R. D. Baughman (1979) 6-Thioguanine resistant peripheral blood lymphocytes in humans following psoralen, long wave ultraviolet light (PUVA) therapy. J. Invest. Dermatol. 73, 211-216.
9. Brash, D. E. , J. A. Rudolph, J. A. Simon, A. Lin, G. J. McKenna, H. P. Baden, A. J. Halpern and J. PontÇn (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. USA 88, 10124-10128.
10. Greenblatt, M. S. , W. P. Bennett, M. Hollstein and C. C. Harris (1994) Mutations in p53 tumor suppression gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855-4878.
11. Fields, S. and S. K. Jang (1990) Presence of a potent transcription activating sequence in the p53 protein. Science 249, 1046-1049.
12. Raycroft, L. , H. Y. Wu and G. Lozano (1990) Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249, 1049-1051.
13. Dittmer, D. , S. Pati, G. Zambetti, S. Chu, A. K. Teresky, M. Moore, C. Finlay and A. J. Levine (1993) Gain of function mutations in p53. Nat. Genet. 4, 42-46.
14. Kanjilal, S. , W. E. Pierceall, K. K. Cummings, M. L. Kripke and H. N. Ananthaswamy (1993) High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors; evidence for strand bias and tumor heterogeneity. Cancer Res 53, 2961-2964.
15. Harris, C. C. (1993) p53: At the crossroads of molecular carcinogens and risk assessment. Science 262, 1980-1981.
16. Sage, E. and A. Bredberg (1991) Damage distribution and mutation spectrum: the case of 8-methoxypsoralen plus UVA in mammalian cells. Mutat. Res. 263, 217-222.
17. Gunther, E. J. , T. Yeasky, F. P. Gasparro and P. M. Glazer (1995) Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations at crosslinkable sites by monoadducts as well as crosslinks. Cancer Res. 55, 1283-1288.
18. Nataraj, A. J., H. S. Black and H. N. Ananthaswamy (1996) Signature p53 mutations at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers. Proc. Natl. Acad. Sci. USA 93, 7961-7965.
19. Schmitt, I. , V. M. Maxwell, G. O. Olack, S. Chimenti, R. L. Edelson and F. P. Gasparro (1994) The specific effects of 8-methoxypsoralen photoadducts on cell survival: HPLC analysis of monoadduct and crosslink formation in cells exposed to split-dose treatment. J. Photochem. Photobiol. B22: 17-21.
20. Sahger, D. and B. Strauss (1983) Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides. Biochemistry 22, 4518-4526.
21. Wrone-Smith, T. , T. Johnson, B. Nelson, L. H. Boise, C. B. Thompson, G. Nunez and B. J. Nickoloff (1995) Discordant expression of bcl-x and bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. Am. J. Pathol. 146, 1079-1088.
22. Perry, M. E. , J. Pettite, J. A. Zawadzki and A. J. Levine (1993) The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc. Natl. Acad. Sci. USA 90, 11623-11627.
23. Momand, J. and G. P. Zambetti (1996) Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics. Oncogene 12, 2279-2289.
24. Ueda, H. , S. J. Ullrich, J. D. Gangemi, C. A. Rappel, L. Ngo, M. A. Feitelson and G. Jay (1995) Functional inactivation but not structural mutation of p53 causes liver cancer. Nat. Genet. 9, 41-47.
25. Pierceall, W. E. , M. L. Kripke and H. N. Ananthaswamy (1992) N-ras mutation in ultraviolet radiation-induced murine skin cancers. Cancer Res. 52, 3946-3951.
26. Nataraj, A. J., P. Wolf, L. Cerroni and H. A. Ananthaswamy (1997) Mutations in squamous cell carcinomas from psoriasis patients treated with psoralen plus UVA (PUVA). J. Invest. Dermatol. In press.