The role of autoantibodies in Lambert-Eaton myasthenic syndrome

Annals of the New York Academy of Sciences

Volumn 841, Issue , 1998, Pages 596-605

  Lang, Bethan ^a   Waterman, Sally ^a   Pinto, Ashwin ^a   Jones, Dominic ^a   Moss, Fraser ^b   Boot, John ^b   Brust, Paul ^c   Williams, Mark ^c   Stauderman, Kenneth ^c   Harpold, Michael ^c   Motomura, Masakatsu ^d   Moll, J Wibe ^e   Vincent, Angela ^a   Newsom Davis, John ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d NAGASAKI UNIVERSITY   (Japan)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AUTOANTIBODY; CALCIUM ION; IMMUNOGLOBULIN G; ION CHANNEL; POTASSIUM ION;

ACETYLCHOLINE RELEASE; ANTIBODY DETECTION; ANTIGEN BINDING; AUTOIMMUNE DISEASE; AUTONOMIC DYSFUNCTION; CALCIUM TRANSPORT; CONFERENCE PAPER; EATON LAMBERT SYNDROME; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MUSCLE WEAKNESS; NERVE ENDING; NEUROMUSCULAR TRANSMISSION; RADIOIMMUNOASSAY; TENDON REFLEX;

EID: 0031902713     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10992.x     Document Type: Conference Paper

References (28)

1. ANDERSON, H. J., H. C. CHURCHILL-DAVIDSON & A. T. RICHARDSON. 1983. Bronchial neoplasm with myasthenia. Lancet ii: 1291.
2. LAMBERT, E. H., L. M. EATON & E. D. ROOKE. 1956. Defect of neuromuscular conduction associated with malignant neoplasma. Am. J. Physiol. 187: 612-613.
3. LAMBERT, E. H. & D. ELMQVIST. 1971. Quantal components of end-plate potentials in the myasthenic syndrome. Ann. N.Y. Acad. Sci. 183: 183-199.
4. LANG, B., J. NEWSOM-DAVIS, C. PEERS, C. PRIOR & D. W. WRAY. 1987. The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse. J. Physiol. (Lond.) 390: 257-270.
5. FUKUNAGA, H., A. G. ENGEL, B. LANG, J. NEWSOM-DAVIS & A. VINCENT. 1983. Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Proc. Natl. Acad. Sci. U.S.A. 80: 7636-7640.
6. O'NEILL, J. H., N. M. MURRAY & J. NEWSOM-DAVIS. 1988. The Lambert-Eaton myasthenic syndrome: a review of 50 cases. Brain 111: 577-596.
7. MCCANN, F. V., O. S. PETTENGILL, J. J. COLE, J. A. G. RUSSELL & G. D. SORENSON. 1981. Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung. Science 212: 1155-1157.
8. 2+ flux in a human small cell carcinoma line. Nature 317: 737-739.
9. JOHNSTON, I., B. LANG, K. LEYS & J. NEWSOM-DAVIS. 1994. Heterogeneity of calcium channel autoantibodies detected using a small-cell lung cancer line derived from a Lambert-Eaton myasthenic syndrome patient. Neurology 44: 334-338.
10. DE AIZPURUA, H. J., E. H. LAMBERT, G. E. GRIESMANN, B. M. OLIVERA & V. A. LENNON. 1988. Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndrome by autoantibodies, omega-conotoxin, and adenosine. Cancer Res. 48: 4719-4724.
11. TSEIN, R. W., D. LIPSCOMBE, D. V. MADISON, K. R. BLEY & A. P. FOX. 1988. Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci. 11: 431-438.
12. UCHITEL, O. D., D. A. PROTTI, V. SANCHEZ, B. D. CHERSKEY, M. SUGIMORI & R. LLINAS. 1992. P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses. Proc. Natl. Acad. Sci. U.S.A. 89: 3330-3333.
13. 2+ channels in supporting hippocampal synaptic transmission. Science 264: 107-111.
14. HONG, S. J. & C. C. CHANG. 1995. Inhibition of acetylcholine release from mouse motor nerve by a P-type calcium channel blocker ω-agatoxin IVA. J. Physiol. (Lond.) 482(2): 283-290.
15. BOWERSOX, S. S., G. P. MILJANICH, Y. SUGIURA, L. NADASDI, B. B. HUFFMAN, J. RAMACHANDRAN & C. P. KO. 1995. Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel ω-cono peptides and Aga IVA. J. Pharmacol. Exp. Ther. 273: 248-256.
16. 2+ flux in tumor cells correlates with disease severity. Ann. Neurol. 25: 265-271.
17. OGURO-OKANO, M., G. E. GRIESMANN, E. D. WIEBEN, S. J. SLAYMAKER, T. P. SNUTCH & V. A. LENNON. 1992. Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma. Mayo Clin. Proc. 67: 1150-1159.
18. PANCRAZIO, J. J., H. K. OIE & Y. I. KIM. 1992. Voltage-sensitive calcium channels in human small-cell lung cancer cell line. Acta Physiol. Scand. 144: 463.
19. SHER, E., N. CANAL, G. PICCOLO, C. GOTTI, C. SCOPPETTA, A. EVOLI & F. CLEMENTI. 1989. Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet ii: 640-643.
20. LEYS, K., B. LANG, A. VINCENT & J. NEWSOM-DAVIS. 1989. Calcium channel antibodies in Lambert-Eaton myasthenic syndrome. Lancet ii: 1107.
21. LENNON, V. A. & E. H. LAMBERT. 1989. Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome. Mayo Clin. Proc. 64: 1498-1504.
22. MOTOMURA, M., I. JOHNSTON, B. LANG, A. VINCENT & J. NEWSOM-DAVIS. 1995. An improved diagnostic assay for Lambert-Eaton myasthenic syndrome. J. Neurol. Neurosurg. Psychiatry 58: 85-87.
23. MOTOMURA, M., B. LANG, I. JOHNSTON, J. PALACE, A. VINCENT & J. NEWSOM-DAVIS. 1997. Incidence of serum anti-P/Q-type and anti-N-type calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. J. Neurol. Sci. 147: 35-42.
24. LENNON, V. A., T. J. KRYZER, G. GRIESMANN, P. E. O'SUILLEABHAIN, A. J. WINDEBANK, A. WOPPMANN, G. P. MILJANICH & E. H. LAMBERT. 1995. Calcium channel antibodies in Lambert-Eaton syndrome and other neuroplastic syndromes. N. Engl. J. Med. 332: 1467-1474.
25. MASON, W. P., F. GRAUS, B. LANG, J. HONNORAT, J-Y. DELATTRE, A. VALLDEORIOLA, J. C. ANTOINE, M. K. ROSENBLUM, M. R. ROSENFELD, J. NEWSOM-DAVIS, J. B. POSNER & J. DALMAU. 1997. Small-cell lung cancer, paraneoplastic cerebellar degeneration, and the Lambert-Eaton myasthenic syndrome. Brain. 120: 1279-1300.
26. WATERMAN, S. A. 1996. Multiple types of voltage-gated calcium channel mediate transmitter release from parasympathetic neurons in the mouse bladder. J. Neurosci. 16: 4155-1161.
27. WATERMAN, S. A. 1997. Role of N-, P-, and Q-type voltage-gated calcium channels in transmitter release from sympathetic neurones in the mouse isolated vas deferens. Br. J. Pharmacol. 120: 393-398.
28. WATERMAN, S. A., B. LANG & J. NEWSOM-DAVIS. 1997. Effects of Lambert-Eaton myasthenic syndrome antibodies on autonomic neurons in the mouse. Ann. Neurol. In press.