The glio-toxic mechanism of α-aminoadipic acid on cultured astrocytes

Journal of Neurocytology

Volumn 27, Issue 2, 1998, Pages 109-118

  Brown, David R ^a   Kretzschmar, Hans A ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOADIPIC ACID; GLIOTOXIN; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ISOMER; MICROGLIA; MITOSIS; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

2-AMINOADIPIC ACID; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL DIVISION; CELLS, CULTURED; ISOMERISM; MICE; MICE, INBRED C57BL; NEUROGLIA;

ANIMALIA;

EID: 0031897605     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006947322342     Document Type: Article

References (32)

1. BRIDGES, R. L., HATALSKI, C. G., SHIM, S. N., CUMMINGS, B. J., VIJAYAN, V. & KUNDI, A. (1992) Gliotoxic actions of excitatory amino acids. Neuropharmacology 31, 899-907.
2. 2 of glutamate transport in astrocyte cultures. Journal of Neurochemistry 50, 1117-22.
3. BROWN, D. R., SCHMIDT, B. & KRETZSCHMAR, H. A. (1996) A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture. Glia 18, 59-67.
4. CHANG, Y.-F. (1978) Lysine metabolism in the rat brain: the pipecolic acid-forming pathway. Journal of Neurochemistry 30, 347-54.
5. COLLINGRIDGE, G. L. & DAVIES, J. (1981) The influence of striatal stimulation and putative neurotransmitters on identified neurones in the rat substantia nigra. Brain Research 212, 345-59.
6. GARLIN, A. B., SINOR, A. D., SINOR, J. D., LEE, S. H., GRINSPAN, J. B. & ROBINSON, M. B. (1995) The pharmacology of sodium-dependent high-affinity L[3H]glutamate transport in glial cultures. Journal of Neurochemistry 64, 2572-80.
7. GIULIAN, D. & BAKER, T. J. (1986) Characterization of ameboid microglia isolated from developing mammalian brain. Journal of Neuroscience 6, 2163-78.
8. HUCK, S., GRASS, F. & HATTEN, M. E. (1984a) Gliotoxic effects of α-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum. Neuroscience 12, 783-91.
9. HUCK, S., GRASS, F. & HÖRTNAGL, H. (1984b) The glutamate analogue α-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effects in vitro. Journal of Neuroscience 4, 2650-7.
10. KATO, S., ISHITA, S., SUGAWARA, K. & MAWATARI, K. (1993) Cystine/glutamate antiporter expression in retinal Müller glial cells. Neuroscience 57, 473-82.
11. 2+ exchanged in cultured rat astrocytes. Journal of Neurochemistry 64, 1536-40.
12. KHRUGEL, M., KOO, A. C. & IVY, G. O. (1996) Selective ablation of astrocytes by intracerebral injections of α-aminoadipate. Glia 16, 351-8.
13. LEVISON, S. W. & McCARTHY, K. D. (1991) Astroglia in culture. In Culturing Nerve Cells (edited by BAKER, G. & GOSLIN, K.) pp. 309-36. Cambridge, MA: MIT Press.
14. McBEAN, G. J. (1994) Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, α-aminoadipate. British Journal of Pharmacology 113, 536-40.
15. MacDONALD, J. F. & WOJTOWICZ, J. M. (1982) The effects of L-glutamate and its analogues upon the membrane conductance of central murine neurons in culture. Canadian Journal of Physiology and Pharmacology 60, 282-96.
16. OKA, A., BELLIVEAU, M. J., ROSENBERG, P. A. & VOLPE, J. J. (1993) Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms and prevention. Journal of Neuroscience 13, 1441-53.
17. OLNEY, J. W., HO, O. L. & RHEE, V. (1971) Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system. Experimental Brain Research 14, 61-76.
18. OLNEY, J. W., DE GUBAREFF, T. & COLLINS, J. F. (1980) Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate. Neuroscience Letters 19, 277-82.
19. c-in the macrophage-induced glutamate cytotoxicity to neurons. Journal of Immunology 152, 3578-85.
20. +-dependent glutamate transport into acutely isolated Müller glia from guinea pig retina. Pflügers Archives 429, 140-2.
21. PEARLMAN, E. M., SEIGEL, G. M. & NOTTER, M. F. D. (1993) Induction of c-fos by excitatory amino acids in developing chick retina is affected by changes in cellular interactions. Journal of Neuroscience Research 36, 252-9.
22. SAFFRAN, B. N. & CRUTCHER, K. A. (1987) Putative gliotoxic, α-aminoadipic acid, fails to kill hippocampal astrocytes in vivo. Neuroscience Letters 81, 215-20.
23. SAGARA, J. I., MIURA, K. & BANNAI, S. (1993) Maintenance of neural glutathione by glial cells. Journal of Neurochemistry 61, 1672-6.
24. STEPHENS, G. J., DJAMGOZ, M. B. A. & WILKIN, G. P. (1993) A patch clamp study of excitatory amino acid effects on cortical astrocyte subtypes in culture. Receptor Channels 1, 39-52.
25. SUGAWARA, K., TORIGOE, K., OKOYAMA, S., NEGISHI, K. & KATO, S. (1990) Neurotoxic effects of L-α-aminoadipic acid on the carp retina: a long term observation. Neuroscience 36, 155-63.
26. SWANSON, R. A. (1992) Astrocyte glutamate uptake during chemical hypoxia in vitro. Neuroscience Letters 147, 143-6.
27. TADAKA, M. & HATTORI, T. (1986) Fine structural changes in the rat brain after local injections of gliotoxin, alpha-aminoadipic acid. Histology and Histopathology 1, 271-5.
28. 2+ exchanger in cultured rat astrocytes. Journal of Neurochemistry 64, 1536-40.
29. TSAI, M. J., CHANG, Y-F., SCHWAKCZ, R. & BROOKES, N. (1996) Characterization of the L-α-aminoadipic acid transport in cultured rat astrocytes. Brain Research 741, 166-73.
30. VOLTERRA, A., TROTTI, D., TROMBA, C., FLORIDI, S. & RACAGNI, G. (1994) Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. Journal of Neuroscience 14, 2924-32.
31. 3H-GABA. Developmental Brain Research 10, 265-77.
32. WYLLIE, D. J. A., MATHIE, W. A., SYMONDS, C. J. & CULL-CANDY, S. G. (1991) Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures. Journal of Physiology 432, 235-58.