Characterization of L-α-aminoadipic acid transport in cultured rat astrocytes

Brain Research

Volumn 741, Issue 1-2, 1996, Pages 166-173

  Tsai, May J ^a,c   Chang, Yung Feng ^a   Schwarcz, Robert ^b   Brookes, Neville ^b  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

excitotoxin; gliotoxin; glutamate; quisqualate; system x(c) ; uptake

Indexed keywords

AMINOADIPIC ACID; EXCITOTOXIN; GLUTAMIC ACID; QUISQUALIC ACID; SODIUM;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

2-AMINOADIPIC ACID; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BIOLOGICAL TRANSPORT, ACTIVE; BUFFERS; CELLS, CULTURED; CHLORIDES; EXCITATORY AMINO ACID ANTAGONISTS; HYPOTONIC SOLUTIONS; KINETICS; POTASSIUM; RATS; SODIUM; TEMPERATURE;

EID: 0030602077     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)00910-9     Document Type: Article

References (48)

1. [1] Bannai, S., Exchange of cystine and glutamate across plasma membrane of human fibroblasts, J. Biol. Chem., 261 (1986) 2256-2263.
2. [2] Bernasconi, R., Klein, M., Martin, P., Christen, P., Hafner, T., Portet, C. and Schmutz, M., Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice, J. Neural Transm., 72 (1988) 213-233.
3. [3] Bradford, M.M., Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72 (1976) 248-254.
4. [4] Bridges, R.J., Hatalski, G., Shim, S.N., Cummings, B.J., Vijayan, V. and Kund, A., Gliotoxic actions of excitatory amino acids, Neuropharmacology, 31 (1992) 899-907.
5. [5] Buchli, R., Alberati-Giani, D., Malherbe, P., Köhler, C., Broger, C. and Cesura, A.M. Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney, J. Biol. Chem. 270 (1995) 29330-29335.
6. [6] Casper, D.S. and Reif-Lehrer, L., Effects of alpha-aminoadipate isomers on the morphology of the isolated chick embryo retina, Invest. Ophthalmol. Vis. Sci., 24 (1983) 1480-1488.
7. [7] Chang, Y.F., Pipecolic acid pathway: the major lysine metabolic route in the rat brain, Biochem. Biophys. Res. Commun., 69 (1976) 174-180.
8. [8] Chang, Y.F., Lysine metabolism in the rat brain: the pipecolate-forming pathway, J. Neurochem., 30 (1978) 347-354.
9. [9] Charles, A.K. and Chang, Y.F., Uptake, release and metabolism of D-and L-α-aminoadipate by rat cerebral cortex, J. Neurochem., 36 (1981) 1127-1136.
10. [10] Cho, Y. and Bannai, S., Uptake of glutamate and cystine in C-6 glioma cells and in cultured astrocytes, J. Neurochem., 55 (1990) 2091-2097.
11. [11] Fletcher, E.J. and Johnston, G.A.R. Regional heterogeneity of L-glutamate and L-aspartate high-affinity uptake systems in the rat CNS, J. Neurochem., 57 (1991) 911-914.
12. [12] Gabay, S. and Clarke, C.C., Aminotransferases. In A. Lajtha (Ed.), Handbook of Neurochemistry, Vol. 4, 2nd edn., Plenum Press, New York, 1983, pp. 67-83.
13. 3H]glutamate transport in glial cultures, J. Neurochem., 64 (1995) 2572-2580.
14. [14] Garthwaite, J. and Regan, C.M., Toxic effects of alpha-aminoadipate on cultured cerebellar cells, Brain Res., 194 (1980) 603-607.
15. [15] Hall H.G., McLennan, H. and Wheal, H.V., The actions of certain amino acids as neuronal excitants, J. Physiol., 272 (1977) 52P.
16. [16] Harris, E.W., L-α-aminoadipate antagonizes the priming effect of quisqualate in hippocampus slices, Eur. J. Pharmacol., 161 (1989) 107-109.
17. [17] Harris, E.W., Stevens, D.R. and Cotman, C.W., Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site, Brain Res., 418 (1987) 361-365.
18. [18] Harrison, P.S. and Kilpatrick, I.C., Hippocampal slices do not appear to accumulate low micromolar concentrations of quisqualate by an active uptake mechanism, Neurosci. Lett., 127 (1991) 177-180.
19. [19] Hertz, L., Juurlink, B.H.J., Fosmark, H. and Schousboe, A., Astrocytes in primary culture. In Pfeiffer, S.E. (Ed.), Neuroscience Approached Through Cell Culture, Vol. 1., CRC, Boca Raton, FL, 1982, pp. 175-186.
20. [20] Huck, S., Grass, F. and Hörtnagl, H., The glutamate analogue alpha-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro, J. Neurosci., 4 (1984) 2650-2657.
21. [21] Huck, S., Grass, F. and Hatten, M.E., Gliotoxic effects of α-aminoadipate on monolayer cultures of dissociated postnatal mouse cerebellum, Neuroscience, 12 (1984) 783-791.
22. [22] Iwata, H., Koyama, Y. and Baba, A., Depolarization increases chloride-dependent glutamate sequestration in synaptic membranes of rat cerebral cortex, J. Neurochem., 52 (1989) 354-359.
23. [23] Kato, S., Sugawara, K., Matsukawa, T. and Negishi, K., Gliotoxic effects of alpha-aminoadipic acid isomers on the carp retina: a long term observation, Neuroscience, 36 (1990) 145-153.
24. [24] Kato, S., Ishita, S., Sugawara, K. and Mawatari, K., Cystine/glutamate antiporter expression in retinal Müller glial cells:implications for DL-alpha-aminoadipate toxicity, Neuroscience, 57 (1993) 473-482.
25. + in primary astrocytes cultures, J. Neurosci., 9 (1989) 1141-1149.
26. [26] Littman, L., Chase, L.A., Renzi, M., Garlin, A.B., Koerner, J.F., Johnson, R.L. and Robinson, M.B., Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus, Neuropharmacology, 34 (1995) 829-841.
27. [27] McBean, G.J., Intrastriatal injection of DL-α aminoadipate reduces kainate toxicity in vitro, Neuroscience, 34 (1990) 225-234.
28. [28] McBean, G.J., Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha-aminoadipate, Br. J. Pharmacol., 113 (1994) 536-540.
29. [29] McCarthy, K.D. and de Vellis, J., Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue, J. Cell Biol., 85 (1980) 890-902.
30. [30] Murphy, T.H., Schnaar, R.L. and Coyle, J.T., Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake, FASEB J., 4 (1990) 1624-1633.
31. [31] Olney, J.W., deGubareff, T. and Collins, J.F., Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate, Neurosci. Lett., 19 (1980) 277-282.
32. +-dependent glutamate transport into acutely isolated Müller glial cells from guinea pig retina, Pflügers Arch. - Eur. J. Physiol., 429 (1994) 140-142.
33. [33] Price, R.H., Jr., Schulte, M.K., Renno, W.M., Koerner, J.F. and Beitz, A.J., Immunocytochemical evidence that quisqualate is selectively internalized into a subset of hippocampal neurons, Brain Res., 663 (1994) 317-325.
34. [34] Recasens, M., Pin, J.P. and Bockaert, J., Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes, Neurosci. Lett., 74 (1987) 211-216.
35. [35] Rich, K.A., Figueroa, S.L., Zhan, Y. and Blanks, J.C., Effects of Muller cell disruption on mouse photoreceptor cell development, Exp. Eye Res., 61 (1995) 235-248.
36. [36] Robinson, M.B. and Dowd, L.A., Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system, Adv. Pharmacol., 37 (1996) 69-115.
37. [37] Robinson, M.B., Whittemore, E.R., Marks, R.L. and Koerner, J.F., Exposure of hippocampal slices to quisqualate sensitizes synaptic responses to phosphonate-containing analogues of glutamate, Brain Res., 381 (1986) 187-190.
38. [38] Schousboe, A., Svenneby, G. and Hertz, L., Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres, J. Neurochem., 9 (1977) 999-1005.
39. [39] Schulte, M.K., Roon, R.J. and Koerner, J.F., Quisqualic acid induced sensitization and the active uptake of L-quisqualic acid by hippocampal slices, Brain Res., 605 (1993) 85-92.
40. [40] Schwarcz, R., Du, F., Schmidt, W., Turski, W.A., Gramsbergen, J.B.P., Okuno E. and Roberts, R.C., Kynurenic acid: a potential pathogen in brain disorders. In J.W. Langston and A. Young (Eds.), Neurotoxins and Neurodegenerative Disease, Vol, 648, Ann. NY Acad. Sci., New York, 1992, pp. 140-153.
41. [41] Sugawara, K., Torigoe, K., Okoyama, S., Negishi, K. and Kato, S., Neurotoxic effects of L-α-aminoadipic acid on the carp retina: a long term observation, Neuroscience, 36 (1990) 155-163.
42. [42] Takada, M., Li, Z.K. and Hattori, T., Astroglial ablation prevents MPTP-induced nigrostriatal neuronal death, Brain Res., 509 (1990) 55-61.
43. [43] Tsai, M.J. and Lee, E.H.Y., Differences in the disposition and toxicity of 1-methyl-4-phenylpyridinium in cultured rat and mouse astrocytes, Glia, 12 (1994) 329-335.
44. [44] Turner, J.P., Anion transport blockers inhibit DL-2-amino-4-phosphonobutyrate responses induced by quisqualate in the rat cerebral cortex, Br. J. Pharmacol., 109 (1993) 449-458.
45. [45] Westergaard, N., Sonnewald, U. and Schousboe, A., Release of alpha-ketoglutarate, malate and succinate from cultured astrocytes -possible role in amino acid neurotransmitter homeostasis, Neurosci. Lett., 176 (1994) 105-109.
46. [46] Whittemore, E.R. and Koerner, J.F., Novel recognition site for L-quisqualate sensitizes neurons to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4), Brain Res., 489 (1989) 146-152.
47. [47] Whittemore, E.R. and Koerner, J.F., Pre-exposure to L-homocysteinesulfinic acid blocks quisqualate-induced sensitization to L-2-amino-4-phosphonobutanoic acid, Eur. J. Pharmacol., 192 (1991) 435-438.
48. [48] Wu, H.-Q., Ungerstedt, U. and Schwarcz, R., L-α-Aminoadipate as a regulator of kynurenic acid production in the rat hippocampus: a microdialysis study in freely moving rats, Eur. J. Pharmacol., 281 (1995) 55-61.