Pre-eclampsia - Still a disease of theories?

Current Opinion in Obstetrics and Gynecology

Volumn 10, Issue 2, 1998, Pages 129-133

  Higgins, John R ^a   Brennecke, Shaun P ^a  

^a ROYAL WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; CALCIUM; CD63 ANTIGEN; INHIBIN A; THROMBOCYTE ANTIGEN;

BLOOD PRESSURE MONITORING; CLINICAL TRIAL; ENDOTHELIUM LESION; FEMALE; GENETICS; HUMAN; LEUKOCYTE ADHERENCE; PATHOPHYSIOLOGY; PREECLAMPSIA; PRIORITY JOURNAL; REVIEW; TROPHOBLASTIC DISEASE;

FEMALE; HUMANS; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY;

EID: 0031897015     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001703-199804000-00009     Document Type: Review

References (43)

1. Zweifel P. Eklampsie. In Handbuch der Geburtshilfe, Vol. II. Doderlein A (editor). Wiesbaden: Bergmann; 1916. pp. 672-723. Quoted by Chesley L. Hypertensive disorders in pregnancy. London: Appleton-Century-Crofts; 1978.
2. Zweifel P. Eklampsie. In Handbuch der Geburtshilfe, Vol. II. Doderlein A (editor). Wiesbaden: Bergmann; 1916. pp. 672-723. Quoted by Chesley L. Hypertensive disorders in pregnancy. London: Appleton-Century-Crofts; 1978.
3. Roberts JM, Redman CWG. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 1993; 341:1447-1451.
4. Cooper DW, Brennecke SP, Wilton AN. Genetics of pre-eclampsia. Hypertension in Pregnancy 1993; 12:1-23.
5. Cooper DW, Liston WA. Genetic control of severe pre-eclampsia. J Med Genet 1979; 16:409-416.
6. Arngrimsson R, Bjornsson H, Geirsson RT. Analysis of different inheritance patterns in pre-eclampsia/eclampsia syndrome. Hypertension in Pregnancy 1995; 14:27-38.
7. Thornton JG, Onwude JL. Pre-eclampsia: discordance among identical twins. BMJ 1991; 303:1241-1242.
8. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265:2037-2045.
9. Arngrimsson R, Hayward C, Nadaud S, Baldursdottir A, Walker JJ, Liston • WA, et al. Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. Am J Hum Genet 1997; 61:354-362. This study uses a candidate gene approach to show a familial pre-eclampsia susceptibility locus in the region of the eNOS gene. This work now needs to be confirmed or refuted in other pedigrees.
10. Lyall F, Greer IA. The vascular endothelium in normal pregnancy and pre-eclampsia. Rev Reprod 1996; 1:107-116.
11. Arngrimsson R, Purandare S, Connor M, Walker JJ, Bjornsson S, Soubrier R, et al. Angiotensinogen: a candidate gene involved in preeclampsia? Nat Genet 1993; 4:114-115.
12. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, et al. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 1993; 4:59-61.
13. Wilton AN, Kaye JA, Guo G, Brennecke SP, Cooper DW. Is angiotensinogen a good candidate gene for preeclampsia? Hypertension in Pregnancy 1995; 14:251-260.
14. Harrison GA, Humphrey KE, Jones N, Badenhop R, Guo G, Elakis G, et • al. A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am J Hum Genet 1997; 60:1158-1167. This is an important report of a genome-wide scan for linkage. Further studies using this approach are needed but with more genetic markers and a greater number of pedigrees.
15. Genbacev O, Zhou Y, Ludlow JW, Fisher SJ. Regulation of human placental development by oxygen tension. Science 1997; 277:1669-1672.
16. Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, •• Damsky CH. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest 1997; 99:2139-2151. This group of researchers continue to lead the field in improving our understanding of the processes leading to normal and abnormal placentation. Here they report that invading trophoblasts 'switch' phenotypically from epithelial to endothelial. They thus mimic the endothelial cells they ultimately displace in the spiral arterioles.
17. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of • human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest 1997; 99:2152-2164. This study reports that pre-eclampsia is associated with a failure of the invading trophoblasts to 'switch' to a vascular adhesion phenotype.
18. Ahmed A, Li XF, Dunk C, Whittle MH, Rushton DI, Rollason T. Colocalisation of vascular endothelial growth factor and its Flt-1 receptor in human placenta. Growth Factors 1995; 12:235-243.
19. Sharkey AM, Charnock-Jones DS, Boocock CA, Brown KD, Smith SK. Expression of vascular endothelial growth factor in human placenta. J Reprod Fertil 1993; 99:609-615.
20. Cooper JC, Sharkey AM, Charnock-Jones DS, Palmer CR, Smith SK. VEGF mRNA levels in placentae from pregnancies complicated by pre-eclampsia. Br J Obstet Gynaecol 1996; 103:1191-1196.
21. Lyall F, Greer IA, Boswell F, Fleming R. Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia. Br J Obstet Gynaecol 1997; 104:223-228.
22. Picker LJ. Mechanisms of lymphocyte homing. Curr Opin Immunol 1992; 4:277-286.
23. Harlan JD. Neutrophil-mediated vascular damage. Acta Med Scand 1987; 715 (suppl.): 123-129.
24. Pigott R, Dillon LP, Hemingway LH, Gearing AJH. Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biopbys Res Commun 1992; 2:584-589.
25. Austgulen R, Lien E, Vince G, Redman CWG. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 71:53-58.
26. Krauss T, Kuhn W, Lakoma C, Augustin HG. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia. Am J Obstet Gynecol 1997; 177:443-449.
27. Djurovic S, Schjetlein R, Wisloff F, Haugen G, Berg K. Increased levels of intercellular adhesion molecules and vascular cell adhesion molecules in pre-eclampsia. Br J Obstet Gynaecol 1997; 104:466-470.
28. Lyall F, Greer IA, Boswell F, Macara LM, Walker JJ, Kingdom JCP. The cell adhesion molecule, VCAM-1, is selectively elevated in serum in pre-eclampsia: does this indicate the mechanism of leucocyte activation? Br J Obstet Gynaecol 1994; 101:485-487.
29. Pober JS, Cotran RS. What can be learned from the expression of endothelial adhesion molecules in tissues? Lab Invest 1991; 64:301-305.
30. Vince GS, Starkey PM, Austgulen R, Kwiatowski D, Redman CWG. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 1995; 102:20-25.
31. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, et al. •• Trial of calcium to prevent preeclampsia. N Engl J Med 1997; 337:69-76. An important paper which reports a large prospective randomized study performed in the USA and which shows no significant benefit of calcium supplementation in the prevention of pre-eclampsia. This result emphasizes the caution needed in using meta-analysis to help answer important clinical questions.
32. Lopez-Jaramillo P, Narvaez M, Felix C, Lopez A. Dietary calcium supplementation and prevention of pregnancy hypertension [letter]. Lancet 1990; 335:293.
33. Belizan JM, Villar J, Gonzalez L, Campodonico L, Bergel E. Calcium supplementation to prevent hypertensive disorders of pregnancy. N Engl J Med 1991; 325:1399-1405.
34. Bucher HC, Guyatt GH, Cook RJ, Hatala R, Cook DJ, Lang JD, Hunt D. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA 1996; 275:1113-1117.
35. Carroli G, Duley L, Belizan JM, Villar J. Calcium supplementation during pregnancy: a systematic review of randomised controlled trials. Br J Obstet Gynaecol 1994; 101:753-758.
36. O'Brien WF. Predicting pre-eclampsia. Obstet Gynecol 1990; 75:445-449.
37. O'Brien E, Mee F, Halligan A, Atkins N, O'Malley K. Accuracy of the Spacelabs 90207 ambulatory blood pressure measuring systems in normotensive pregnant women determined by the British Hypertension Society Protocol. J Hypertens 1993; 11 (suppl. 5):S282-S283.
38. Shennan A, Halligan A, Gupta M, Taylor D, deSwiet M. Oscillometric blood pressure measurement in severe pre-eclampsia: validation of the SpaceLabs 90207. Br J Obstet Gynaecol 1996; 103:171-173.
39. Higgins JR, Walshe JJ, Halligan A, O'Brien E, Conroy R. Darling MRN. • Can 24-hour ambulatory blood pressure measurement predict the development of hypertension in primigravidae? Br J Obstet Gynaecol 1997; 104:356-362. The largest study so far to assess the use of ABPM in pregnancy reported that in a primigravid population, ABPM was not a useful predictive test for the development of pre-eclampsia.
40. Halligan A, Shennan A, Lambert PC, Bell SC, Taylor DJ, de Swiet M. Automated blood pressure measurement as a predictor of proteinuric pre-eclampsia. Br J Obstet Gynaecol 1997; 104:559-562.
41. Peek M, Shennan A, Halligan AWF, Lambert PC, Taylor DJ, de Swiet M. Hypertension in pregnancy: which method of blood pressure measurement is most predictive of outcome? Obstet Gynecol 1996; 88:1030-1033.
42. Konijnenberg A, van der Post JAM, Mol BW, Schaap MCL, Lazarov R, Bleker OP, et al. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of pre-eclampsia? A prospective study. Am J Obstet Gynecol 1997; 177:434-442.
43. Muttukrishna S, Knight PG, Groome NP, Redman CWG, Ledger WL. Activin A and inhibin A as possible endocnne markers for pre-eclampsia. Lancet 1997; 349:1285-1288.