Screening aspartyl proteases with combinatorial libraries

Advances in Experimental Medicine and Biology

Volumn 436, Issue , 1998, Pages 375-380

  Carroll, Carolyn DiIanni ^a   Orlowski, Marc ^a  

^a PHARMACOPEIA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; CATHEPSIN D; PLASMEPSIN II; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; CONFERENCE PAPER; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CHEMISTRY; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

PLASMODIUM FALCIPARUM;

EID: 0031894225     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5373-1_52     Document Type: Conference Paper

References (23)

1. Goldberg, D.E., Slater, A.F.G., Cerami, A. and Henderson, G.B. (1991) J. Exp. Med. 173, 961-969.
2. Francis, S.E., Gluzman, I.Y. Oksman, A., Knickerbocker, A., Mueller, Bryant, M.L., Sherman, D.R., Russell, D.G., and Goldberg, D.E. (1994) EMBO J, 13, 306-317.
3. Baldwin, E.T., Bhat, T.N., Gulnik, S., Hosur, M.V., Sowder, R.C., Cachau, R.E., Collins, J., Sivia, A.M., and Erickson, J.W. (1993) Proc. Natl. Acad. Sci., 90, 6796-6800.
4. Silva, A.M., Lee, A.Y., Gulnik, S.V., Majer, P., Collins, J., Bhat, T.N., Collins, P.J., Cachau, R.E., Luker, K.E., Gluzman, I.Y., Francis, S.E., Oksman, A., Goldberg, D.E., and Erickson, J.W. (1996) Proc. Natl. Acad. Sci. 93, 10034-10039.
5. Luker, K.E., Francis, S.E., Gluzman, I.Y. and Goldberg, D.E. (1996) Molecular and Biochemical Parasitology 79, 71-78.
6. Segel, I.H. (1975) Enzyme Kinetics, New York, Wiley.
7. Matayoshi, E.D., Wang, G.T., Krafft, G.A., and Erickson, J. (1990) Science 247, 954-958.
8. Scarborough, P.E., Guruprasad, K., Topham, C., Richo, G.R., Conner, G.E., Blundell, T.L. and Dunn, B.M. (1993) Protein Science 2, 264-276.
9. Scarborough, P.E., and Dunn, B.M. (1994) Protein Engineering 7, 495-502.
10. (a) Chabala, J.C. (1995) Current Opinion in Biotechnology 6, 632-639.
11. (b) Ellman, J.A. (1996) Chem. Rev. 96, 555-600.
12. Burbaum, J.J., Ohlmeyer, M.H.J., Reader, J.C., Henderson, I., Dillard, L.W., Li, G., Randle, T.L., Sigal, N.H., Chelsky, D., and Baldwin, J.J. (1995) Proc. Natl. Acad. Sci. USA 92, 6027-6031.
13. Apell, K.C., Chung, T.D.Y., Ohlmeyer, M.J.H., Sigal, N.H., Baldwin, J.J., and Chelsky, D. (1996) J. of Biomolecular Screening 1, 27-31.
14. Sebestyen, M., Dibo, G., Kovacs, A., and Furka, A. (1993) Biorg. Med. Chem. Lett. 3, 413-416.
15. Gallop, M.A., Barrett, R.W., Dower, W.J., Fodor, S.P.A., and Gordon, E.M. (1994) J. Med. Chem. 37, 1233-1251.
16. Gordon, E.M., Barrett, R.W., Dower, W.J., Fodor, S.P.A., and Gallop, M.A. (1994) J. Med. Chem. 37, 1385-1401.
17. Ohlmeyer, M.H.J., Swanson, R.N., Dillard, L.W., Reader, J.C., Asouline, G., Kobayashi, R., Wigler, M., and Still, W.C. (1993) Proc. Natl. Acad. Sci. USA 90, 10922-10926.
18. Nestler, H.P., Bartlett, P.A. and Still, W.C. (1994) J. Org. Chem. 59, 4723-4724.
19. Pearl L., and Blundell, T., (1984) FEBS Letters 174, 96-101.
20. Blundell, T.L., Cooper, J., Foundling, Jones, D.M., Atrash, B., and Szelke, M., (1987) Biochemistry 26, 5585-5590.
21. Abdel-Meguid, S.S. (1993) Medicinal Research Reviews 13, 731-778.
22. Shewale, J. G., Takahashi, R. and Tang, J. In Aspartic Proteinases and Their Inhibitors, Kostka, V., Ed. Wlater de Gruyter: Berlin, 1986; pp 101-116.
23. Rich, D. H. In Proteinase Inhibitors; Barrett, A. J., Salvensen, G., Eds.; Elsevier Science Publishers B. V.: Amsterdam, 1986; Chapter 5 and references therein.