Insulin resistance and fat patterning with aging: Relationship to metabolic risk factors for cardiovascular disease

Metabolism: Clinical and Experimental

Volumn 47, Issue 4, 1998, Pages 401-408

  Cefalu, William T ^a   Werbel, Sandra ^b   Bell Farrow, Audrey D ^b   Terry, James G ^b   Wang, Zhong Q ^b   Opara, Emmanuel C ^b   Morgan, Timothy ^b   Hinson, William H ^b   Crouse III, John R ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ARTICLE; BLOOD PRESSURE MONITORING; CARDIOVASCULAR DISEASE; DYSLIPIDEMIA; FEMALE; HUMAN; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; RISK FACTOR;

EID: 0031891323     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90050-6     Document Type: Article

References (45)

1. Rowe JW, Minake KL, Pallotta JA, et al: Characterization of insulin resistance of aging. J Clin Invest 71:1581-1587, 1983
2. Fink RI, Koltermann OG, Griffin J, et al: Mechanism of insulin resistance in aging. J Clin Invest 71:1523-1535, 1983
3. Coon PJ, Rogus EM, Drinkwater D, et al: Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J Clin Endocrinol Metab 75:1125-1132, 1992
4. Kohrt WM, Kirwan JP, Staten MA, et al: Insulin resistance in aging is related to abdominal obesity. Diabetes 42:273-281, 1993
5. Cefalu WT, Wang ZQ, Werbel S, et al: Contribution of visceral fat mass to the insulin resistance of aging. Metabolism 44:954-959, 1995
6. Reaven GM, Lithell H, Landsberg L: Hypertension and associated metabolic abnormalities - The role of insulin resistance and the sympa-thoadrenal system. N Engl J Med 334:374-381, 1996
7. Laakso M: Insulin resistance and coronary heart disease. Curr Opin Lipidol 7:217-226, 1996
8. Despres J-P: Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 9:452-459, 1993
9. Matsuzawa Y, Nakamura T, Shimomura I, et al: Pathophysiology and pathogenesis of visceral fat obesity. Obes Res 2:187S-194S, 1995 (suppl)
10. Park KS, Rhee BD, Lee KU, et al: Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism 40:600-603, 1991
11. Bonora E, Del Prato S, Bonadonna RC, et al: Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women. Diabetes 41:1151-1159, 1992
12. Zamboni M, Armellini F, Turcato E, et al: Relationship between visceral fat, steroid hormones and insulin sensitivity in premenopausal obese women. J Intern Med 236:521-527, 1994
13. Caprio S, Hyman LD, Limb C, et al: Central adiposity and its metabolic correlates in obese adolescent girls. Am J Physiol 269:E118-E126, 1995
14. Abate N, Garg A, Peshock RM, et al: Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96:88-98, 1995
15. Soler JT, Folsom AR, Kaye SA, et al: Associations of abdominal adiposity, fasting insulin, sex hormone binding globulin, and estrone with lipids and lipoproteins in post-menopausal women. Atherosclerosis 79:21-27, 1989
16. 2 cholesterol level in older adults. N Engl J Med 322:229-234, 1990
17. Selby JV, Austin MA, Newman B, et al: LDL subclass phenotypes and the insulin resistance syndrome in women. Circulation 88:381-387, 1993
18. Ward KD, Sparrow D, Vokonas PS, et al: The relationships of abdominal obesity, hyperinsulinemia and saturated fat intake to serum lipid levels: The Normative Aging Study. Int J Obes 18:137-144, 1994
19. Burchfiel CM, Shetterly SM, Baxter J, et al: The roles of insulin, obesity, and fat distribution in the elevation of cardiovascular risk factors in impaired glucose tolerance. The San Luis Valley Diabetes Study. Am J Epidemiol 136:1101-1109, 1992
20. Weinsier RL, Norris DJ, Birch R, et al: Serum insulin and blood pressure in an obese population. IJ Obes 10:11-17, 1986
21. Laws A, Reaven GM: Evidence for an independent relationship between insulin resistance and fasting plasma HDL-cholesterol, triglyceride and insulin concentrations. J Intern Med 231:25-30, 1992
22. Allemann Y, Horber FF, Colombo M, et al: Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Lancet 341:327-331, 1993
23. Mykkanen L, Haffner SM, Ronnemaa T, et al: Is there a sex difference in the association of plasma insulin level and insulin sensitivity with serum lipids and lipoproteins? Metabolism 43:523-528, 1994
24. Walton C, Lees B, Crook D, et al: Relationships between insulin metabolism, serum lipid profile, body fat distribution and blood pressure in healthy men. Atherosclerosis 118:35-43, 1995
25. Lind L, Andersson P-E, Andren B, et al: Left ventricular hypertrophy in hypertension is associated with the insulin resistance metabolic syndrome. J Hypertens 13:433-438, 1995
26. Karhapaa P, Voutilainen E, Malkki M, et al: Obese men with type IIB hyperlipidemia are insulin resistant. Arterioscler Thromb 13:1469-1475, 1993
27. Pollare T, Lithell H, Berne C: Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 39:167-174, 1990
28. Boyko EJ, Leonetti DL, Bergstrom RW, et al: Visceral adiposity, fasting plasma insulin, and blood pressure in Japanese-Americans. Diabetes Care 18:174-181, 1995
29. Ferland M, Despres JP, Nadeau A, et al: Contribution of glucose tolerance and plasma insulin levels to the relationships between body fat distribution and plasma lipoprotein levels in women. Int J Obes 15:677-688, 1991
30. Johnson D, Prud'homme D, Despres JP, et al: Relation of abdominal obesity to hyperinsulinemia and high blood pressure in men. Int J Obes 16:881-890, 1992
31. Peins AN, Sothmann MS, Hoffmann RG, et al: Adiposity, fat distribution, and cardiovascular risk. Ann Intern Med 110:867-872, 1989
32. Bergman RN: Toward physiological understanding of glucose tolerance - Minimal model approach. Diabetes 38:1512-1527, 1989
33. Terry JG, Hinson WH, Evans GW, et al: Evaluation of magnetic resonance imaging for quantification of intraabdominal fat in human beings by spin-echo and inversion-recovery protocols. Am J Clin Nutr 62:297-301, 1995
34. Thompson CJ, Ryu JE, Craven TE, et al: Central adipose distribution is related to coronary atherosclerosis. Arterioscler Thromb 11:327-333, 1991
35. Seidell JC, Bakker CJG, Van der Kooy K: Imaging techniques for measuring adipose tissue distribution - A comparison between computed tomography and 1.5 magnetic resonance. Am J Clin Nutr 51:953-957, 1990
36. Welch S, Gebhart SSP, Bergman RN, et al: Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetes subjects. J Clin Endocrinol Metab 71:1508-1518, 1990
37. Finegood DT, Hramiak IM, Dupre J: A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes. J Clin Endocrinol Metab 70:1538-1549, 1990
38. Lipid Research Clinics: Manual I, DHEW No. (NIH) 75-628. Bethesda, MD, National Heart, Lung, and Blood Institute, 1974
39. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem 18:499-502, 1972
40. Clausen JO, Borch-Johnsen K, Ibsen H, et al: Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest 98:1195-1209, 1996
41. Haffner SM, Karhapaa P, Rainwater DL, et al: Insulin sensitivity and Lp(a) concentrations in normoglycemic men. Diabetes Care 18:193-199, 1995
42. Reaven GM: Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
43. Depres JP: Dyslipidaemia and obesity. Baillieres Clin Endocrinol Metab 8:629-660, 1994
44. Defronzo RA: Lilly Lecture 1987. The triumvirate: β-Cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687, 1988
45. Opara EC, Garfinkel M, Hubbard VS, et al: Effect of fatty acids on insulin release: Role of chain length and degree of unsaturation. Am J Physiol 266:E635-E639, 1994