Lymphocyte subsets in multiple sclerosis A study with two-colour fluorescence analysis

Journal of the Neurological Sciences

Volumn 139, Issue 1, 1996, Pages 71-77

  Bongioanni, Paolo ^a   Fioretti, Cristina ^a   Vanacore, Renato ^a   Bianchi, Fabrizio ^a   Lombardo, Francesco ^a   Ambrogi, Fabio ^a   Meucci, Giuseppe ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Immunofluorescence cytometry; Lymphocyte subsets; Memory cells; Multiple sclerosis; Naive cells; T cell subsets

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMETRY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

EID: 0030200975     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(96)00030-5     Document Type: Article

References (41)

1. Bertouch, J.V., P.J. Roberts-Thompson and J. Bradley (1983) Diurnal variation of lymphocyte subsets identified by monoclonal antibodies. Br. Med. J., 286: 1771-1772.
2. Buttinelli, C., V. Barnaba, R. Benvenuto, S. Bernardi and M. Levrero (1983) Suppressor cell activity and T cell subset in multiple sclerosis. Proceedings of the XXIII Congress of the Italian Neurological Society. Parma. pp. 13-22.
3. Caldwell, C.W. and H.M. Taylor (1986) A rapid, no-wash for immunophenotypic analysis by flow cytometry. Am. J. Clin. Pathol., 86: 600-607.
4. +) T-cells in multiple sclerosis cerebrospinal fluid. Ann. Neurol., 25: 494-499.
5. +) T cells in multiple sclerosis. Ann. Neurol., 24: 185-191.
6. Compston, A. (1983) Lymphocyte subpopulations in patients with multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 46: 106-114.
7. Crockard, A.D., T.A. McNeill, J. McKirgan and S.A. Wawkins (1988) Determination of activated lymphocytes in peripheral blood of patients with multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 51: 139-141.
8. Dufour, A., A. Salmaggi, M. Eoli, L. La Mantia, C. Milanese and A. Nespolo (1993) Phenotype analysis of unstimulated lymphocytes and anti-CD3-stimulated proliferating T-cells from cerebrospinal fluid and peripheral blood in patients with multiple sclerosis and other neurological diseases. Int. J. Neurosci., 73: 277-285.
9. Eoli, M., M. Ferrarini, A. Dufour, S. Heltaj, L. Bevilacqua, G. Comi, V. Cosi, G. Filippini, V. Martinelli and C. Milanese (1993) Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short term clinical activity. J. Neurol., 240: 79-82.
10. Frequin, S.T.F.M., K.J.B. Lamers, J.F. Borm, F. Barkhof, P.J.H. Jongen and O.R. Hommes (1993) T cell subsets in the cerebrospinal fluid and peripheral blood of multiple sclerosis patients treated with high-dose intravenous methylprednisolone. Acta Neurol. Scand., 88: 80-86.
11. Hamman, K.P. and H.C. Hopf (1986) Monocytes constitute the only peripheral blood cell population showing an increased burst activity in multiple sclerosis patients. Int. Arch. Allergy Appl. Immunol., 81: 230-234.
12. Hauser, S.L., E.L., Reinherz, C.J. Hoban, S.F. Schlossman and H.L. Weiner (1983) Immunoregolatory T-cells and lymphocytotoxic antibodies in active multiple sclerosis: weekly analysis over a six-month period. Ann. Neurol., 13: 418-425.
13. Hirsch, R.L., J. Ordonez, H.S. Panitch and K.P. Johnson (1985) T8 antigen density on peripheral blood lymphocytes remains unchanged during exacerbations of multiple sclerosis. J. Neuroimmunol., 9: 391-398.
14. Ilonen, J., H.M. Surcel, H. Jagerroos, T. Nurmi and M. Reunanen (1990) T-lymphocyte subsets defined by double immunofluorescence in multiple sclerosis. Acta Neurol. Scand., 81: 128-130.
15. Kastrukoff, L.F. and D.W. Paty (1984) A serial study of peripheral blood T lymphocyte subsets in relapsing-remitting multiple sclerosis. Ann. Neurol., 15: 250-256.
16. Kreutzfelder, E, G. Shen, M. Bittorf, N. Scheiermann, O. Thraenhart, D. Seidel and H. Grosse-Wilde (1992) Enumeration of T, B and Natural Killer peripheral blood cells of patients with multiple sclerosis and controls. Eur. Neurol., 32: 190-194.
17. Kurtzke, J.F. (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology, 33: 1444-1452.
18. Madigand, M., J.J.F. Oger, R. Fauchet, O. Saboraud and B. Genetet B (1982) HLA profiles in multiple sclerosis suggest two forms of disease and the existence of protective haplotypes. J. Neurol. Sci., 53: 519-529.
19. Marrosu, M.G. (1991) Decrease in memory (CDw29-high) cerebrospinal fluid cells from acute multiple sclerosis patients. Acta Neurol. Scand., 84: 487-490.
20. McCallum, K., M.M. Esiri and W.W. Tourtellotte (1987) T cell subsets in multiple sclerosis lesions. Brain, 110: 1297-1308.
21. Merkenschlager, M, L. Terry, R. Edwards and P.C.L. Beverly (1988) Limiting dilution analysis of proliferative responses in human lymphocyte subpopulations defined by monoclonal antibody UCHL-I: implication for differential CD 45 expression in T cell memory formation. Eur. J. lmmunol., 18: 1653-1658.
22. Miller, D.H., I.E.C. Ormerod and G.H. Du Boulay (1987) A summary of the present contribution of magnetic resonance imaging to diagnosis and understanding of multiple sclerosis. In F.C. Rose and R. Jones (Eds.). Multiple Sclerosis: Immunological. Diagnostic and Therapeutic Aspects. John Libbey. London, pp. 121-127.
23. Morimoto, C., N.L. Letvin, A.W. Boyd, M. Hagan, H.M. Brown, M.M. Kornacki and S.F. Schlossmann (1985a) The isolation and characterization of the human helper inducer T-cell subset. J. Immunol., 134: 3762-3769.
24. Morimoto, C, N.L. Letvin, J.A. Distaso, W.R. Aldrich and S.F. Schlossman (1985b) The isolation and characterization of the human suppressor inducer T cell subset. J. Immunol., 134: 1508-1515.
25. Morimoto, C, D.A. Hafler, H.L. Weiner, N.L. Letvin, M. Hagan, J. Daley and S.F. Schlossman (1987) Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. N. Engl. J. Med., 316: 67-72.
26. O'Gorman, M. and J. Oger (1987) Cell-mediated immune functions in multiple sclerosis. Pathol. Immunopathol. Res., 6: 241-272.
27. + lymphocytes in multiple sclerosis. J. Neurol., 239: 437-440.
28. Poser, C.M., D.W. Paty and L. Scheinberg (1983) New diagnostic criteria for multiple sclerosis. Ann. Neurol., 13: 227-231.
29. Reder, A.T., J.P. Antel and J.J.F. Oger (1984) Low T8 antigen density on lymphocytes in active multiple sclerosis. Ann. Neurol., 16: 242-249.
30. Reinherz, E.L., H.L. Weiner, S.L. Hauser, J.A. Cohen, J.A. Distaso and S.F. Schlossman (1980) Loss of suppressor T cells in active multiple sclerosis: analysis with monoclonal antibodies. N. Engl. J. Med., 303: 125-129.
31. Rep, M.H., R.Q. Hintzen, C.H. Polman and R.A. van Lier (1994) Functional defects in peripheral blood T cells of multiple sclerosis patients. Diminished in vitro responsiveness in accessory cell dependent activation systems. J. Neuroimmunol., 52: 139-146.
32. Rice, G.P.A., D.F. Finney, S.L. Brahemy, R.L. Knobler, J.C. Sipe and M.B.A. Oldstone (1984) Disease activity markers in multiple sclerosis. Another look at suppressor cells defined by monoclonal antibodies OKT4, OKT5 and OKT8. J. Neuroimmunol., 6: 75-84.
33. Rose, L.M., A.H. Ginsberg and T.L. Rothstein (1985) Selective loss of subset of T-helper cells in active multiple sclerosis. Proc. Natl. Acad. Sci. USA. 82: 7389-7393.
34. Sanders, M.E., W. Malegapuru, M.W. Makgoba and S. Shaw (1988) Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets. Immunol. today, 9: 195-198.
35. Schumacher, G.A., G. Beebe, R.F. Kibler, L.T. Kurland, J.F. Kurtzke, F. McDowell, B. Nagler, W.A. Sibley, W.W. Tourtellotte and J. William (1965) Problems of experimental trials of therapy in multiple sclerosis. Ann. N.Y. Acad. Sci., 122: 552-568.
36. Scolozzi, R., A. Boccafogli, M.R. Tola, L. Vicentini, A. Camerani, D. Degani, E. Granieri, L. Caniatti and E. Paolino (1992) T-cell phenotypic profiles in the cerebrospinal fluid and peripheral blood of multiple sclerosis patients. J. Neurol. Sci., 108: 93-98.
37. Sobel, R.A., D.A. Hafler and E.E. Castro (1988) The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. J. Immunol., 140: 2210-2214.
38. Traugott, U. (1984) Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoimmune demyelinating lesions. Springer Semin. Immunopathol., 8: 71-95.
39. Waksman, B.H. and W.E. Reynolds (1984) Multiple sclerosis as a disease of immune regulation. Proc. Soc. Exp. Biol. Med., 175: 282-294.
40. Woodroofe, M.N., A.S. Bellamy and M. Feldmann (1986) Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis. J. Neurol. Sci., 174: 135-152.
41. + T cells in chronic progressive multiple sclerosis. J. Neurol., 237: 1-4.