Methotrexate and cyclooxygenase metabolism in cultured human rheumatoid synoviocytes

Journal of Rheumatology

Volumn 25, Issue 3, 1998, Pages 433-440

  Vergne, Pascale ^a,b   Liagre, Bertrand ^a,b   Bertin, Philippe ^a,b   Cook Moreau, Jeanne ^a,b   Treves, Richard ^a,b   Beneytout, Jean Louis ^a,b   Rigaud, Michel ^a,c  

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

^b Department of Therapeutics ^*

^c University of Medicine of Limoges

Author keywords

Cyclooxygenase; Human synoviocytes; Methotrexate; Prostaglandins; Rheumatoid arthritis

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; INTERLEUKIN 1BETA; MESSENGER RNA; METHOTREXATE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ANTIRHEUMATIC AGENTS; ARACHIDONIC ACID; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; FOLIC ACID ANTAGONISTS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; METHOTREXATE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 0031887481     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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