1α-Hydroxyvitamin D2 partially dissociates between preservation of cancellous bone mass and effects on calcium homeostasis in ovariectomized rats

Calcified Tissue International

Volumn 60, Issue 5, 1997, Pages 449-456

  Erben, R G ^a   Bante, U ^a   Birner, H ^a   Stangassinger, M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Calcitrol; Histomorphometry; Osteoporosis; Ovariectomy; Rats; Vitamin D

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; ALFACALCIDOL; CALCITRIOL; CALCIUM; COLLAGEN; CREATININE; DOXERCALCIFEROL; OXYTETRACYCLINE; PHOSPHATE; 1 ALPHA HYDROXYERGOCALCIFEROL; 1 ALPHA-HYDROXYERGOCALCIFEROL; 1-HYDROXYCHOLECALCIFEROL; BIOLOGICAL MARKER; CALCIFEDIOL; ERGOCALCIFEROL; HYDROXYCOLECALCIFEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MASS; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CANCELLOUS BONE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LUMBAR SPINE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; OVARIECTOMY; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RAT; TIBIA; ANIMAL; BLOOD; BODY WEIGHT; BONE; BONE DENSITY; DRUG EFFECT; FISCHER 344 RAT; HOMEOSTASIS; METABOLISM; OSTEOLYSIS; PATHOLOGY; URINE;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CALCIFEDIOL; CALCITRIOL; CALCIUM; COLLAGEN; CREATININE; ERGOCALCIFEROLS; FEMALE; HOMEOSTASIS; HYDROXYCHOLECALCIFEROLS; OVARIECTOMY; PHOSPHATES; RATS; RATS, INBRED F344;

EID: 0030611744     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900261     Document Type: Article

References (48)

1. Fujita T (1992) Vitamin D in the treatment of osteoporosis. Proc Soc Exp Biol Med 199:394-399
2. Tilyard MW, Spears GF, Thomson J, Dovey S (1992) Treatment of postmenopausal osteoporosis with calcitriol or calcium. N Engl J Med 326:357-362
3. Gallagher JC, Goldgar D (1990) Treatment of postmenopausal osteoporosis with high doses of synthetic calcitriol. A randomized controlled study. Ann Intern Med 113:649-655
4. 3. Bone Miner 20:223-234
5. 3. Science 180:190-191
6. Caniggia A, Gennari C, Bianchi V, Guideri R (1963) Intestinal absorption of Ca in senile osteoporosis. Acta Med Scand 173: 613-617
7. Morris HA, Need AG, Horowitz M, O'Loughlin PD, Nordin BE (1991) Calcium absorption in normal and osteoporotic postmenopausal women. Calcif Tissue Int 49:240-243
8. Hunt RD, Garcia FG, Walsh RJ (1972) A comparison of the toxicity of ergocalciferol and cholecalciferol in rhesus monkeys (Macaco mulatto). J Nutr 102:975-986
9. 3 in the rat. Proc Soc Exp Biol Med 178:432-436
10. 3. J Am Vet Med Assoc 182:1358-1369
11. 2. Arch Biochem Biophys 197:119-125
12. Sjödén G, Lindgren JU, DeLuca HF (1984) Antirachitic activity of 1α-hydroxyergocalciferol and 1α-hydroxycholecalciferol in rats. J Nutr 114:2043-2046
13. 3 analogs on osteoporosis caused by ovariectomy in rats. Acta Vitaminol Enzymol 7: 173-181
14. Erben RG, Weiser H, Sinowatz F, Rambeck WA, Zucker H (1992) Vitamin D metabolites prevent vertebral osteopenia in ovariectomized rats. Calcif Tissue Int 50:228-236
15. 3. Calcif Tissue Int 50:221-227
16. Erben RG, Kohn B, Rambeck WA, Zucker H (1990) Histomorphometric analysis of the rat proximal tibial metaphysis by "linear scanning." Scanning Microsc 4:625-638
17. Baron R, Vignery A, Neff L, Silverglate A, Santa Maria A (1983) Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR (ed) Bone histomorphometry: techniques and interpretation. CRC Press, Boca Raton, FL, pp 13-35
18. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610
19. Erben RG, Kohn B, Weiser H, Sinowatz F, Rambeck WA (1990) Role of vitamin D metabolites in the prevention of the osteopenia induced by ovariectomy in the axial and appendicular skeleton of the rat. Z Ernährungswiss 29:229-248
20. Wronski TJ, Dann LM, Horner SL (1989) Time course of vertebral osteopenia in ovariectomized rats. Bone 10:295-301
21. Wronski TJ, Cintron M, Dann LM (1988) Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int 43:179-183
22. 3 on ovariectomy-induced cancellous bone loss in the rat. Calcif Tissue Int (in press)
23. Martin TJ, Raisz LG, Rodan G (1987) Calcium regulation and bone metabolism. In: Martin TJ, Raisz LG (eds) Clinical endocrinology of calcium metabolism. Marcel Dekker, New York, pp 1-52
24. 3. Lab Invest 48:683-689
25. 3-treated rats fed high levels of dietary calcium. Bone 6:105-112.
26. Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey Holton ER (1986) Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization. Endocrinology 119:2580-2585
27. 3 on osteoporosis induced by immobilization combined with ovariectomy in rats. Bone 8:351-355
28. 3: short- and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis. Proc Natl Acad Sci USA 79: 3325-3329
29. Need AG, Horowitz M, Philcox JC, Nordin BE (1985) 1,25-Dihydroxycalciferol and calcium therapy in osteoporosis with calcium malabsorption. Dose-response relationship of calcium absorption and indices of bone turnover. Miner Electrolyte Metab 11:35-40
30. 2, and its 24 epimer. Arch Biochem Biophys 273:64-71
31. 3 binding protein: specificity of binding. Steroids 30:245-257
32. 2. Biochemistry 14: 1250-1256
33. 2 and their (24R)-epimers. Anal Biochem 161:96-102
34. 2 analogs on calcium metabolism in vitamin D-deficient rats and in MC3T3-E1 osteoblastic cells. Res Exp Med Berl 191:235-242
35. Horst RL, Napoli JL, Littledike ET (1982) Discrimination in the metabolism of orally dosed ergocalciferol and cholecal-ciferol by the pig, rat and chick. Biochem J 204:185-189
36. Gallagher JC, Bishop CW, Knutson JC, Mazess RB, DeLuca HF (1994) Effects of increasing doses of la-hydroxy vitamin D2 on calcium homeostasis in postmenopausal osteopenic women. J Bone Miner Res 9:607-614
37. 2 in mammals. Biochemistry 29:578-582
38. 2 made in the human hepatoma. Hep3B. Biochem J 310:233-241
39. 3 in rats and monkeys. Endocrinology 136:4749-4753
40. 3. Bone 16:129-135
41. Dilworth FJ, Scott I, Green A, Strugnell S, Guo Y-D, Roberts EA, Kremer R, Calverley MJ, Makin HLJ, Jones G (1995) Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism. J Biol Chem 270:16766-16774
42. Guo Y-D, Strugnell S, Back DW, Jones G (1993) Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side chain positions. Proc Natl Acad Sci USA 90:8668-8672
43. 3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria. Bone Miner 3:125-136
44. 3 in bones from fetal rats. Calcif Tissue Int 35:177-182
45. 3 increases epidermal growth factor receptors and transforming growth factor beta-like activity in a bone-derived cell line. J Biol Chem 262:13424-13428
46. 3 stimulation of TGF-β expression in chick embryonic calvarial bone. Differentiation 52:139-150
47. Finkelman RD, Bell NH, Strong DD, Demers LM, Baylink DJ (1992) Ovariectomy selectively reduces the concentration of transforming growth factor β in rat bone: implications for estrogen deficiency-associated bone loss. Proc Natl Acad Sci USA 89:12190-12193
48. 1 decrease ovariectomy-stimulated osteoclastic resorption in vivo in rats. J Bone Miner Res 10:971-977