Glutathione depletion exacerbates impairment by oxidative stress of phosphoinositide hydrolysis, AP-1, and NF-κB activation by cholinergic stimulation

Molecular Brain Research

Volumn 53, Issue 1-2, 1998, Pages 196-205

  Li, Xiaohua ^a   Song, Ling ^a   Jope, Richard S ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

AP 1; Diamide; Glutathione; NF B; Oxidative stress; Phosphoinositide hydrolysis

Indexed keywords

CARBACHOL; DIAMIDE; GLUTATHIONE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITIDE; TRANSCRIPTION FACTOR AP 1;

ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROLYSIS; NERVE DEGENERATION; NEUROBLASTOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; BASE SEQUENCE; BINDING SITES; BUTHIONINE SULFOXIMINE; CARBACHOL; CONSENSUS SEQUENCE; DIAMIDE; GLUTATHIONE; GTP-BINDING PROTEINS; HUMANS; HYDROGEN PEROXIDE; IONOMYCIN; NEUROBLASTOMA; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOLS; SECOND MESSENGER SYSTEMS; SODIUM FLUORIDE; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; VANADATES;

EID: 0031882875     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00290-8     Document Type: Article

References (19)

1. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell. 77:1994;817-827.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:1976;248-254.
3. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 262:1993;689-695.
4. Fisher S.K. Homologous and heterologous regulation of receptor-stimulated phosphoinositide hydrolysis. Eur. J. Pharmacol. 288:1995;231-250.
5. Friedlich A.L., Butcher L.L. Involvement of oxygen radicals in β-amyloidosis: an hypothesis. Neurobiol. Aging. 15:1994;443-455.
6. Griffith O.W., Anderson M.E., Meister A. Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. J. Biol. Chem. 254:1979;1205-1210.
7. Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1992;1609-1623.
8. Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F., Floyd R., Butterfield D.A. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 91:1994;3270-3274.
9. Jope R.S. Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer's disease. Alzheimer's Dis. Rev. 1:1996;2-14.
10. Jope R.S., Li X. Inhibition of inositol phospholipid synthesis and norepinephrine-stimulated hydrolysis in rat brain slices by excitatory amino acids. Biochem. Pharmacol. 38:1989;589-596.
11. Jope R.S., Casebolt T.L., Johnson G.V.W. Modulation of carbachol-stimulated inositol phospholipid hydrolysis in rat cerebral cortex. Neurochem. Res. 12:1987;693-700.
12. Jope R.S., Song L., Powers R.E. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiol. Aging. 18:1997;111-120.
13. Kosower N.S., Kosower E.M. Diamide: an oxidant probe for thiols. Methods Enzymol. 251:1995;123-133.
14. Li X., Song L., Jope R.S. Cholinergic stimulation of AP-1 and NFκB transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis. J. Neurosci. 16:1996;5914-5922.
15. Meister A. Glutathione biosynthesis and its inhibition. Methods Enzymol. 252:1995;26-30.
16. Morgan J.I., Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14:1991;421-451.
17. Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA. 91:1994;10771-10778.
18. Siebenlist U., Franzoso G., Brown K. Structure, regulation and function of NFκB. Annu. Rev. Cell Biol. 10:1994;405-455.
19. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and tissues. Anal. Biochem. 27:1969;502-520.