Detection of human papillomavirus 16 transcriptional activity in cervical intraepithelial neoplasia grade III lesions and cervical carcinomas by nested reverse transcription-polymerase chain reaction and in situ hybridization

Laboratory Investigation

Volumn 78, Issue 1, 1998, Pages 9-18

  Selinka, Hans Christoph ^a,b   Sotlar, Karl ^a   Klingel, Karin ^a   Sauter, Martina ^a   Kandolf, Reinhard ^a   Bültmann, Burkhard ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b Abteilung Molekulare Pathologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RISK; FEMALE; GENETIC TRANSCRIPTION; HUMAN; IN SITU HYBRIDIZATION; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; WART VIRUS;

CARCINOMA; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; FEMALE; HUMANS; IN SITU HYBRIDIZATION; ONCOGENES; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR VIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS;

EID: 0031882807     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Baker CC, Phelps WC, Lindgren V, Braun MJ, Gonda MA, and Howley PM (1987). Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol 61:962-971.
2. Böhm S, Wilczynski SP, Pfister H, and Iftner T (1993). The predominant mRNA class in HPV16-infected genital neoplasias does not encode the E6 or E7 protein. Int J Cancer 55:791-798.
3. Chen Z, Kamath P, Zhang S, Weil MM, and Shillitoe EJ (1995). Effectiveness of three ribozymes for cleavage of an RNA transcript from human papillomavirus type 18. Cancer Gene Ther 2:263-271.
4. Chen Z, Kamath P, Zhang S, St John L, Adler-Storthz K, and Shillitoe EJ (1996). Effects on tumor cells or ribozymes that cleave the RNA transcripts of human papillomavirus type 18. Cancer Gene Ther 3:18-23.
5. Chomczynski P and Sacchi N (1987). Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
6. Chong T, Chan WK, and Bernhard HU (1990). Transcriptional activation of human papillomavirus type 16 by NF-1, AP-1, steroid receptors and a possibly novel transcription factor. Nucleic Acids Res 18:465-470.
7. Cornelissen MTE, Smits HL, Briet MA, van den Tweel JG, Struyk APHB, van der Noordaa J, and ter Schegget J (1990). Uniformity of the splicing pattern of the E6/E7 transcripts in human papillomavirus type 16-transformed human fibroblasts, human cervical premalignant lesions and carcinomas. J Gen Virol 71:1243-1246.
8. de Roda Husman AM, Walboomers JMM, van den Brule AJC, Meijer CJLM, and Snijders PJF (1995). The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76:1057-1062.
9. Dürst M, Kleinheinz A, Hotz M, and Gissmann L (1985). The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors. J Gen Virol 66:1515-1522.
10. Dürst M, Glitz D, Schneider A, and zur Hausen H (1992). Human papillomavirus type 16 (HPV16) gene expression and DNA replication in cervical neoplasia: Analysis by in situ hybridization. Virology 189:132-140.
11. Dyson N, Howley PM, Münger K, and Harlow E (1989). The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 2443:934-937.
12. Falcinelli C, Claas E, Kleter B, and Quint WG (1992). Detection of the human papilloma virus type 16 mRNA-transcripts in cytological abnormal scrapings. J Med Virol 37:93-98.
13. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR, and Schiller JT (1989). HPV 16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 8:3905-3910.
14. Hohenadl C, Klingel K, Mertsching J, Hofschneider PH, and Kandolf R (1991). Strand-specific detection of enteroviral RNA in myocardial tissue by in situ hybridization. Mol Cell Probes 5:11-20.
15. Hsu EM and McNicol PJ (1992). Characterization of HPV-16 E6/E7 transcription in CaSki cells by quantitative PCR. Mol Cell Probes 6:459-466.
16. Johnson MA, Blomfield PI, Bevan IS, Woodman CBJ, and Young LS (1990). Analysis of human papillomavirus type 16 E6-E7 transcription in cervical carcinomas and normal cervical epithelium using the polymerase chain reaction. J Gen Virol 71:1473-1479.
17. Kandolf R, Ameis D, Kirschner P, Canu A, and Hofschneider PH (1987). In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: An approach to the diagnosis of viral heart disease. Proc Natl Acad Sci USA 84:6272-6276.
18. Khare S, Kumar KU, Tang SC, Pater MM, and Pater A (1996). Up-regulation of hormone response of human papillomavirus type 16 expression and increased DNA-protein binding by consensus mutations of viral glucocorticoid response elements. J Med Virol 50:254-262.
19. Klingel K, Hohenadl C, Canu A, Albrecht M, Seemann M, Mall G, and Kandolf R (1992). Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: Quantitative analysis of virus replication, tissue damage, and inflammation. Proc Natl Acad Sci USA 89:314-318.
20. Lorincz AT, Reid R, Jenson AB, Greenberg MD, Lancaster W, and Kurman RJ (1992). Human papillomavirus infection of the cervix: Relative risk associations of 15 common anogenital types. Obstet Gynecol 79:328-337.
21. Lu D, Chatterjee S, Brar D, and Wong KKJ (1994). Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16. Cancer Gene Ther 1:267-277.
22. Manos MM, Ting Y, Wright DK, Lewis AJ, Broker TR, and Wolinsky SM (1989). The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. Cancer Cells A Mon Rev 7:209-214.
23. Mitchell MF, Tortolero-Luna G, Wright T, Sarkar A, Richards-Kortum R, Hong WK, and Schottenfeld D (1996). Cervical human papillomavirus infection and intraepithelial neoplasia: A review. J Natl Cancer Inst Monogr 21:17-25.
24. Romanczuk H, Thierry F, and Howley PM (1990). Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 p97 and type 18 p105 promoters. J Virol 64:2849-2859.
25. Rose BR, Thompson CH, Jiang XM, Tattersall MHN, Elliott PM, Dalrymple C, and Cossart YE (1994). Detection of human papillomavirus type 16 E6/E7 transcripts in histologically cancer-free pelvic lymph nodes of patients with cervical carcinoma. Gynecol Oncol 52:212-217.
26. Rose BR, Thompson CH, Tattersall MHN, Elliott PM, Dalrymple C, and Cossart YE (1995). Identification of E6/E7 transcription patterns in HPV16-positive cervical cancers using the reverse transcription/polymerase chain reaction. Gynecol Oncol 56:239-244.
27. Scheffner M, Huibregtse JM, Vierstra RD, and Howley PM (1993). The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquination of p53. Cell 75: 495-505.
28. Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, Stremlau A, and zur Hausen H (1985). Structure and transcription of papillomavirus sequences in cervical carcinoma cells. Nature 314:111-114.
29. Schwarz E, Schneider-Gadicke A, and zur Hausen H (1987). Human papilloma-virus type 18 transcription in cervical carcinoma cell lines and in human cell hybrids. Cancer Cells A Mon Rev 5:47-53.
30. Seedorf K, Kraemmer G, Duerst M, Suhai S, and Roewekamp WG (1985). Human papillomavirus type 16 DNA sequence. Virology 145:181-185.
31. Selinka HC, Sotlar K, Ruck P, Huber M, Klingel K, Bültmann B, and Kandolf R (1995). Differentiation between the presence of human papillomavirus (HPV) types 16 and 18 genomic DNA and transcriptionally active viruses in paraffin-embedded biopsies (abstract). Pathol Res Pract 191:267.
32. Sherman L, Alloul N, Golan I, Dürst M, and Baram A (1992). Expression and splicing patterns of human papillomavirus type-16 mRNAs in pre-cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers. Int J Cancer 50:356-364.
33. Shillitoe EJ, Kamath P, and Chen Z (1994). Papillomaviruses as targets for cancer gene therapy. Cancer Gene Ther 1:193-204.
34. Smith LM, Sanders JZ, Kaiser RJ, Hughes P, Dodd C, Connell CR, Heiner C, Kent SB, and Hood LE (1986). Fluorescence detection in automated DNA sequence analysis. Nature 321:674-679.
35. Smotkin D and Wettstein FO (1986). Transcription of human papillomavirus type 16 early genes in a cervical cancer and cancer derived cell line and identification of the E7 protein. Proc Natl Acad Sci USA 83:4680-4684.
36. Snijders PJF, van den Brule AJC, Schrijnemakers HFJ, Snow G, Meijer CJLM, and Walboomers JMM (1990). The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes. J Gen Virol 71:173-181.
37. Stoler MH, Rhodes CR, Whitbeck A, Wolinski SM, Chow LT, and Broker TR (1992). Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Hum Pathol 23:117-128.
38. Tokunaga K, Nakamura Y, Sakata K, Fujimori K, Ohkubo M, Sawada K, and Sakiyama S (1987). Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res 47:5616-5619.
39. Vousden K (1993). Interaction of human papillomavirus transforming proteins with the products of tumor suppressor genes. FASEB J 7:872-879.
40. Yee C, Krishnan-Hewlett I, Baker CC, Schlegel R, and Howley PM (1985). Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am J Pathol 119:361-366.
41. zur Hausen H (1991). Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.