LPAM-1 (integrin α4β7)-ligand binding: Overlapping binding sites recognizing VCAM-1, MAdCAM-1 and CS-1 are blocked by fibrinogen, a fibronectin-like polymer and RGD-like cyclic peptides

European Journal of Immunology

Volumn 28, Issue 3, 1998, Pages 995-1004

  Yang, Yi ^a   Cardarelli, Pina M ^b   Lehnert, Klaus ^a   Rowland, Shelley ^a   Krissansen, Geoffrey W ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Tanabe Research Laboratories   (United States)

Author keywords

Arg Gly Asp (RGD) cyclic peptides; Cell adhesion; Cell adhesion molecule; Integrin; LPAM 1

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; BETA1 INTEGRIN; CELL ADHESION MOLECULE; FIBRINOGEN; FIBRONECTIN; INTEGRIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B CELL LYMPHOMA; BINDING SITE; CELL ADHESION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HOMEOSTASIS; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; T CELL LYMPHOMA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL ADHESION MOLECULES; CELL LINE; FIBRINOGEN; FIBRONECTINS; HUMANS; IMMUNOGLOBULINS; INTEGRINS; MICE; MOLECULAR SEQUENCE DATA; MUCOPROTEINS; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0031881787     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199803)28:03<995::AID-IMMU995>3.0.CO;2-D     Document Type: Article

References (37)

1. Springer, T. A., Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu. Rev. Physiol. 1995. 57: 827-872.
2. Berlin, C., Bargatze, R. F., Campbell, J. J., von Andrian, U. H., Szabo, M. C., Hasslen, S. R., Nelson, R. D., Berg, E. L., Erlandsen, S. L. and Butcher, E. C., α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995. 80: 413-422.
3. Briskin, M. J., McEvoy, L. M. and Butcher, E. C., MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 1993. 363: 461-464.
4. Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., Weissman, I. L., Hamman, A. and Butcher, E. C., α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1994. 74: 185-195.
5. Yang, Y., Sammar, M., Harrison, J. E. B., Lehnert, K., Print, C. G., Leung, E., Prestidge, R. and Krissansen, G. W., Construction and adhesive properties of a soluble MAdCAM-1-Fc chimera expressed in a baculovirus system: phylogenetic conservation of receptor-ligand interaction. Scand. J. Immunol. 1995. 42: 235-247.
6. Ruegg, C., Postigo, A. A., Skorski, E. E., Butcher, E. C., Pytela, R. and Erle, D. J., Role of integrin α4β7/α4βp in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J. Cell Biol. 1992. 117: 179-189.
7. Chan, B. M. C., Elices, M. J., Murphy, E. and Hemler, M. E., Adhesion to vascular cell adhesion molecule 1 and fibronectin: comparison of α4β1 (VLA-4) and α4β7 on the human B cell line JY. J. Biol. Chem. 1992. 267: 8366-8370.
8. Wayner, E. A. and Kovach, N. L., Activation-dependent recognition by haematopoietic cells of the LDV sequence in the V region of fibronectin. J. Cell Biol. 1992. 116: 489-497.
9. Hynes, R. O., Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992. 69: 11-25.
10. Nowlin, D. M., Gorcsan, F., Moscinski, M., Chiang, S.-L., Lobl, T. J. and Cardarelli, P. M., A novel cyclic pentapeptide inhibits α4β1 and α5β1 integrin-mediated cell adhesion. J. Biol. Chem. 1993. 268: 20352-20359.
11. Cardarelli, P. M., Cobb, R. R., Nowlin, D. M., Scholz, W., Gorcsan, F., Moscinski, M., Yasuhara, M., Chiang, S.-L. and Lobl, T. J., Cyclic RGD peptide inhibits α4β7 interaction with connecting segment 1 and vascular cell adhesion molecule. J. Biol. Chem. 1994. 269: 18668-18673.
12. Sanchez-Aparicio, P., Dominguez-Jimenez, C. and Garcia-Pardo, A., Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin. J. Cell Biol. 1994. 126: 271-279.
13. Wilkins, J., Lyttle, D., Sivananthan, K. and El-Gabalawy, H., Lymphocyte-synovial cell interactions: a role for beta 1 and beta 3 integrin-mediated adhesion to cellular fibronectin. Cell. Immunol. 1993. 146: 313-323.
14. Holzmann, B. and Weissmann, I. L., Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like α chain associated with either of two integrin β chains, one of which is novel. EMBO J. 1989. 8: 1735-1741.
15. Erle, D. J., Briskin, M. J., Butcher, E. C., Garcia-Pardo, A., Lazarovits, A. I. and Tidswell, M., Expression and function of the MAdCAM-1 receptor, integrin α4β7, on human leukocytes. J. Immunol. 1994. 153: 517-528.
16. Koivunen, E., Gay, D. A. and Ruoslahti, E., Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library. J. Biol. Chem. 1993. 268: 20205-20210.
17. Vonderheide, R. H., Tedder, T. F., Springer, T. A. and Staunton, D. E., Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. J. Cell Biol, 1994. 125: 215-222.
18. Osborn, L., Vassallo, C., Browning, B. G., Tizard, R., Haskard, D. O., Benjamin, C. D., Oougas, I. and Kirchhausen, T., Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (α4β1). J. Cell Biol. 1994. 124: 601-608.
19. Leung, E., Greene, J., Ni, J., Raymond, L. G., Lehnert, K., Langley, R. and Krissansen, G. W., Cloning of the mucosal addressin MAdCAM-1 from human brain: Identification of novel alternatively spliced transcripts, Immunol. Cell Biol. 1996. 74: 490-496.
20. Shyjan, A. M., Bertagnolli, M., Kenney, C. J. and Briskin, M. J., Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the α4β7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. J. Immunol. 1996. 156: 2851-2857.
21. Mould, A. P. and Humphries, M. J.,Identification of a novel recognition sequence for the integrin α4β1 in the COOH-terminal heparin-binding domain of fibronectin. EMBO J. 1991. 13: 4089-4095.
22. Andrew, D. P., Berlin, C., Honda, S., Yoshino, T., Hamann, A., Holzmann, B., Kilshaw, P. J. and Butcher, E. C., Distinct but overlapping epitopes are involved in α4β7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J. Immunol. 1994. 153: 3847-3861.
23. Makarem, R., Newham, P., Askari, J. A., Green, L. J., Clements, J., Edwards, M., Humphries, M. J. and Mould, A. P., Competitive binding of vascular cell adhesion molecule-1 and the Hepll IIICS domain of fibronectin to the integrin alpha 4 beta 1. J. Biol. Chem. 1994. 269: 4005-4011.
24. Irie, A., Kamata, T., Puzon-McLaughlin, W. and Takada, Y., Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third N-terminal repeat in the integrin α4 and α5 subunits. EMBO J. 1995. 14: 5550-5556.
25. Pfaff, M., Tangemann, K., Muller, B., Gurrath, M., Muller, G., Kessler, H., Timpl, R. and Engel, J., Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha v beta 3, and alpha 5 beta 1 integrins. J. Biol. Chem. 1994. 269: 20233-20238.
26. Scarborough, R. M., Naughton, M. A., Teng, W., Rose, J. W., Phillips, D. R., Nannizzi, L., Arfsten, A., Campbell, A. M. and Charo, I. F., Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa. J. Biol. Chem. 1993. 268: 1066-1073.
27. Aumailley, M., Gurrath, M., Muller, G., Calvete, J., Timpl, R. and Kessler, H., Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1. FEBS Lett. 1991. 291: 50-54.
28. Kilger, G., Clements, J. and Holzmann, B., Amino acid residues required for binding of vascular cell adhesion molecule-1 to integrin α4β7. Int. Immunol. 1997. 9: 219-226.
29. Kilshaw, P. J. and Murant, S. J., Expression and regulation of beta7 (beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system. Eur. J. Immunol. 1991. 21: 2591-2597.
30. Miyake, K., Weissman, I. L., Greenberger, J. S. and Kincade, P. W., Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J. Exp. Med. 1991. 173: 599-607.
31. Dialynas, D. P., Wilde, D. B., Marrack, P., Pierres, A., Wall, K. A., Havran, W., Otten, G., Loken, M. R., Pierres, M. and Kappler, J., Characterization of the murine antigenic determinant, designated L3T4a, recognized by a monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity, Immunol. Rev. 1983. 74: 29-56.
32. Maxfield, S. R., Moulder, K., Koning, F., Elbe, A., Stingl, G., Coligan, J. E., Shevach, E. M. and Yokoyama, W. M., Murine T cells express a cell surface receptor for multiple extracellular matrix proteins. J. Exp. Med. 1989. 169: 2173-2190.
33. Yang, Y., Harrison, J. E. B., Print, C. G., Lehnert, K., Sammar, M., Lazarovits, A., Krissansen, G. W., Interaction of monocytoid cells with the mucosal addressin MAdCAM-1 via the integrins VLA-4 and LPAM-1. Immunol. Cell Biol. 1996. 74: 383-393.
34. Bebbington, C. R. and Hentschel, C. C. G., The use of vectors based on gene amplification of cloned genes in mammalian cells. In Glover, D. (Ed.) DNA Cloning. Academic press, San Diego 1987, Vol 3 pp 163-188.
35. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. and Struhl, K. (Eds.), Current Protocols in Molecular Biology. Greene Publishing Associates Inc. and John Wiley & Sons Inc. Science, New York, 1989.
36. Pierschbacher, M. D., Hayman, E. G. and Ruoslahti, E., Synthetic peptide with cell attachment activity of fibronectin. Proc. Natl. Acad. Sci. USA 1983. 80: 1224-1227.
37. Cardarelli, P. M. and Pierschbacher, M. D., T-lymphocyte differentiation and the extracellular matrix: identification of a thymocyte subset that attaches specifically to fibronectin. Proc. Natl. Acad. Sci. USA 1986. 83: 2647-2651.