Potential of microsensor-based feedback bioactuators for biophysical cancer treatment

Biosensors and Bioelectronics

Volumn 12, Issue 4, 1997, Pages 301-309

  Wolf, Bernhard ^a   Kraus, Michael ^a   Sieben, Ulrich ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Intermetall Halbleiterwerke der I   (Germany)

Author keywords

immune response; microsensors; neoplastic growth; oxygen; pH; physiocontrol microsystem; tumor invasion

Indexed keywords

ACTUATORS; CELLS; COMPUTER SIMULATION; CONTROLLED DRUG DELIVERY; GROWTH KINETICS; IMMUNOLOGY; ONCOGENIC VIRUSES; ONCOLOGY; PH;

BIOPHYSICAL CANCER TREATMENT; FEEDBACK BIOACTUATORS; IMMUNE RESPONSE; MICROSENSOR; NEOPLASTIC GROWTH; PHYSIOCONTROL MICROSYSTEM; TUMOR INVASION;

BIOSENSORS;

ARTICLE; BIOPHYSICS; BIOSENSOR; CANCER THERAPY; COMPUTER SIMULATION; ELECTRONICS; FEEDBACK SYSTEM; IN VITRO STUDY; PH;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIBODY FORMATION; BIOPHYSICS; BIOSENSING TECHNIQUES; FEEDBACK; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL;

EID: 0030909595     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0956-5663(96)00071-1     Document Type: Article

References (53)

1. Brischwein, M., Baumann, W., Ehret, R., Schwinde, A., Kraus, M. & Wolf, B. (1996). Mikrosensorische Systeme in der zellbiologischen Grundlagenforschung und der medizinischen Diagnostik. Naturwissenschaften, 83, 193-200.
2. Cantley, L.C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R. & Soltoff, S. (1991). Oncogenes and signal transduction. Cell, 64, 281-302.
3. Ceccarini, C. & Eagle, H. (1971). pH as a determinant of cellular growth and contact inhibition. Proc. Natl. Acad. Sci. USA, 68, 229-233.
4. Daly, P.F. & Cohen, J.S. (1989). Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: a review. Cancer Res., 49, 770-779.
5. 2+ associated with apoptosis. Meth. Cell Biol, 46, 41-55.
6. Flier, J.S., Mueckler, M.M., Usher, P. & Lodish, H.F. (1987). Elevated levels of glucose transport and transporter messenger RNA are induced by ras and src oncogenes. Science, 235, 1492-1495.
7. Frelin, C., Vigne, P., Ladoux, A. & Lazdunski, M. (1988). The regulation of the intracellular pH in cells from vertebrates. Eur. J. Biochem., 174, 3-14.
8. Gatenby, R.A. (1995). The potential role of transformation-induced metabolic changes in tumor-host interaction. Cancer Res., 55, 4151-4156.
9. Gerweck, L.E. & Seetharaman, K. (1996). Cellular pH gradients in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res., 56, 1194-1198.
10. Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. & Giaccia, A.J. (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
11. Griffiths, J.R. (1991). Are cancer cells acidic? Br. J. Cancer, 64, 425-427.
12. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim. Biophys. Acta, 988, 73-97.
13. Hasuda, K., Lee, C. & Tannock, I.F. (1994). Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. Oncology Res., 6, 259-268.
14. Hawkins, R.A., Hoh, C., Glaspy, J., Choi, Y., Dahlbom, M., Rege, S. & Messa, C. (1992). The role of positron emission tomography in oncology and other whole-body applications. Semin. Nucl. Med., 22, 268-284.
15. +-dependent Cl-HCO3 exchange in NIH-3T3 fibroblasts. J. Biol. Chem., 269, 4116-4124.
16. Kato, Y., Nakayama, Y., Umeda, M. & Miyazaki, K. (1992). Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. J. Biol. Chem., 267, 11424-11430.
17. Kinzler, K.W. & Vogelstein, B. (1996). Life (and death) in a malignant tumour. Nature, 379, 19-20.
18. Kraus, M., Baumann, W., Brischwein, M., Ehret, R., Leroux, C. & Wolf, B. (1993). Biosensorik mit zellulären Systemen. BioScope, 1, 24-33.
19. Kraus, M., Severin, T. & Wolf, B. (1994). Relevance of microenvironmental pH for self-organized tumor growth and invasion. Anticancer Res., 14, 1573-1584.
20. Kraus, M. & Wolf, B. (1995). Structured Biological Modelling - A New Approach to Biophysical Cell Biology. CRC Press, Boca Raton, Florida.
21. Kraus, M. & Wolf, B. (1996). Implications of acidic tumor microenvironment for neoplastic growth and cancer treatment: a computer analysis. Tumor Biol., 17, 133-154.
22. Loeffler, D.A., Juneau, P.L. & Heppner, G.H. (1991). Natural killer-cell activity under conditions reflective of tumor micro-environment. Int. J. Cancer, 48, 895-899.
23. Loeffler, D.A., Juneau, P.L. & Masserant, S. (1992). Influence of tumor physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation. Br. J. Cancer, 66, 619-622.
24. Madshus, I.H. (1988). Regulation of intracellular pH in eukaryotic cells. Biochem. J., 250, 1-8.
25. Maidorn, R.P., Cragoe, E.J. & Tannock, I.F. (1993). Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy. Br. J. Cancer, 67, 297-303.
26. Marino, A.A., Hiev, I.G., Schwalke, M.A., Gonzalez, E., Marier, K.C. & Flanagan, C.A. (1994). Association between cell membrane potential and breast cancer. Tumor Biol., 15, 82-89.
27. Martin, G.R. & Jain, R.K. (1994). Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res., 54, 5670-5674.
28. Masson, D., Peters, P.J., Geuze, H.J., Borst, J. & Tschopp, J. (1990). Interaction of chondroitin sulfate with perform and granzymes of cytolytic T-cells is dependent on pH. Biochemistry, 29, 11229-11235.
29. Newell, K., Franchi, A., Pouyssegur, J. & Tannock, I. (1993). Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc. Natl. Acad. Sci. USA, 90, 1127-1131.
30. Nordenström, B.E.W. (1983). Biologically Closed Electric Circuits: Clinical, Experimental and Theoretical Evidence for an Additional Circulatory System. Nordic Medical Publications, Stockholm.
31. + in cells. Biochim. Biophys. Acta. 1185, 129-151.
32. Persechini, P.M., Liu, C.C., Jiang, S. & Young, J.D.E. (1989). The lymphocyte pore-forming protein perforin is associated with granules by a pH-dependent mechanism. Immunol. Lett., 22, 23-27.
33. 2+ and pH. J. Immunol., 147, 3638-3645.
34. Reichl, H. & Heuberger, A. (1996). Microsystems Technologies 96. VDE-Verlag GmbH, Berlin.
35. Roepe, P.D. (1992). Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein. Biochemistry, 31, 12,555-12,564.
36. Roepe, P.D., Wei, L.Y., Cruz, J. & Carlson, D. (1993). Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein. Biochemistry, 32, 11,042-11,056.
37. + exchanger for tumor growth. Cancer Res., 49, 205-211.
38. Rotin, D., Wan, P., Grinstein, S. & Tannock, I. (1987). Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs. Cancer Res., 47, 1497-1504.
39. Rozhin, J., Sameni, M., Ziegler, G. & Sloane, B.F. (1994). Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res., 54, 6517-6525.
40. Severin, T., Müller, B., Giese, G., Uhl, B., Wolf, B., Hauschildt, S. & Kreutz, W. (1994). pH-dependent LAK cell cytotoxicity. Tumor Biol., 15, 304-310.
41. Stubbs, M., Veech, R.O. & Griffiths, J.R. (1995). Tumor metabolism: the lessons of magnetic resonance spectroscopy. Adv. Enzyme Regulation, 35, 101-115.
42. Turner, G.A. (1979). Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis. Experientia, 35, 1657-1658.
43. Valera, A., Pujol, A., Gregori, X., Riu, E., Visa, J. & Bosch, F. (1995). Evidence from transgenic mice that myc regulates hepatic glycolysis. FASEB J., 9, 1067-1078.
44. Vaupel, P., Kallinowski, F. & Okunieff, P. (1989). Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49, 6449-6465.
45. Warburg, O. (1930). The Metabolism of Tumors. Arnold Constable, London.
46. Wei, L.Y. & Roepe, P.D. (1994). Low external pH and osmotic shock increase the expression of human MDR protein. Biochemistry, 33, 7229-7238.
47. Weidner, N. (1995). Intratumor microvessel density as a prognostic factor in cancer. Am. J. Pathol., 147, 9-19.
48. + exchange -on NIH 3T3 fibroblasts expressing the RAS oncogene. Eur. J. Pharmacol., 246, 269-273.
49. Wolf, B., Baumann, W., Ehret, R., Brischwein, M., Dumbs, A. & Sulz, G. (1994). Intelligente mikroskopierbare Meßkammer, German patent pending (P 94 378 M).
50. Wolf, B. & Kraus, M. (1995). pH-abhängige Selbstorganisation von Tumorwachstum und Invasion. Dtsch. Zschr. Onkol., 27, 57-71.
51. Wolf, B., Kraus, M. & Sieben, U. (1996). Vorrichtung zur sensorgesteuerten Tumortherapie, Patent pending.
52. Young, P.R. & Spevacek, S.M. (1992). Substratum acidification by murine B16F10 melanoma cultures. Biochim. Biophys. Acta, 1139, 163-166.
53. Young, P.R. & Spevacek, S.M. (1993). Substratum acidification and proteinase activation by murine B16F10 melanoma cultures. Biochim. Biophys. Acta, 1182, 69-74.