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Volumn 24, Issue 2, 1996, Pages 173-181

α-Phenyl-N-tert-butyl nitrone attenuates methamphetamine-induced depletion of striatal dopamine without altering hyperthermia

Author keywords

phenyl N tert butyl nitrone (PBN); Dopamine; Free Radicals; Methamphetamine; Neurotoxicity; Rats

Indexed keywords

DOPAMINE; FREE RADICAL; METHAMPHETAMINE; N TERT BUTYL ALPHA PHENYLNITRONE;

EID: 0029793919     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199610)24:2<173::AID-SYN9>3.0.CO;2-C     Document Type: Article
Times cited : (50)

References (45)
  • 1
    • 0028100290 scopus 로고
    • Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
    • Ali, S.F., Newport, G.D., Holson, R.R., Slikker, W., and Bowyer, J.F. (1994) Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice. Brain Res., 658:33-38.
    • (1994) Brain Res. , vol.658 , pp. 33-38
    • Ali, S.F.1    Newport, G.D.2    Holson, R.R.3    Slikker, W.4    Bowyer, J.F.5
  • 2
    • 0026563868 scopus 로고
    • The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum
    • Bowyer, J.F., Tank, A.W., Newport, G.D., Slikker, W., Ali, S.F., and Holson, R.R. (1992) The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum. J. Pharmacol. Exp. Ther., 260: 817-824.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 817-824
    • Bowyer, J.F.1    Tank, A.W.2    Newport, G.D.3    Slikker, W.4    Ali, S.F.5    Holson, R.R.6
  • 4
    • 0028856659 scopus 로고
    • Age-dependent sensitivity of rats to long-term effects of the serotonergic neurotoxicant 3,4-methlenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response
    • Broening, H.W., Bowyer, J.F., and Slikker, W. (1995) Age-dependent sensitivity of rats to long-term effects of the serotonergic neurotoxicant 3,4-methlenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J. Pharmacol. Exp. Ther. 275:325-333.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 325-333
    • Broening, H.W.1    Bowyer, J.F.2    Slikker, W.3
  • 5
    • 0027972286 scopus 로고
    • Attenuation of methamphetamine-induced neurotoxicity in copper/zinc superoxide dismutase transgenic mice
    • Cadet, J.L., Sheng, P., Ali, S., Rothman, R., Carlson, E., and Epstein, C. (1994) Attenuation of methamphetamine-induced neurotoxicity in copper/zinc superoxide dismutase transgenic mice. J. Neurochem., 62:380-383.
    • (1994) J. Neurochem. , vol.62 , pp. 380-383
    • Cadet, J.L.1    Sheng, P.2    Ali, S.3    Rothman, R.4    Carlson, E.5    Epstein, C.6
  • 6
    • 0025932511 scopus 로고
    • Protection against oxidative damage to CNS by α-phenyl-tert-butyl-nitrone (PBN) and other spintrapping agents: A novel series of nonlipid free radical scavengers
    • Carney, J.M., and Floyd, R.A. (1991) Protection against oxidative damage to CNS by α-phenyl-tert-butyl-nitrone (PBN) and other spintrapping agents: a novel series of nonlipid free radical scavengers. J. Mol. Neurosci., 3:47-57.
    • (1991) J. Mol. Neurosci. , vol.3 , pp. 47-57
    • Carney, J.M.1    Floyd, R.A.2
  • 7
    • 0025832844 scopus 로고
    • Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound α-N-tert-butyl-phenylnitrone
    • Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F., and Floyd, R.A. (1991) Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound α-N-tert-butyl-phenylnitrone. Proc. Natl. Acad. Sci. U.S.A., 88:3633-3636.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 3633-3636
    • Carney, J.M.1    Starke-Reed, P.E.2    Oliver, C.N.3    Landum, R.W.4    Cheng, M.S.5    Wu, J.F.6    Floyd, R.A.7
  • 8
    • 0025173450 scopus 로고
    • Excreation, metabolism and tissue distribution of a spin trapping agent, α-phenyl-n-tert-butyl-nitrone (PBN) in rats
    • Chen, G., Bray, T.M., Janzen, E.G., and McCay, P.B. (1990a) Excreation, metabolism and tissue distribution of a spin trapping agent, α-phenyl-n-tert-butyl-nitrone (PBN) in rats. Free Radic. Res. Commun., 9:317-323.
    • (1990) Free Radic. Res. Commun. , vol.9 , pp. 317-323
    • Chen, G.1    Bray, T.M.2    Janzen, E.G.3    McCay, P.B.4
  • 9
    • 0025045031 scopus 로고
    • HPLC procedure for the pharmacokinetic study of the spin-trapping agent, α-phenyl-N-tert-butyl nitrone (PBN)
    • Chen, G., Griffin, M., Poyer, J.L., McCay, P.B., and Bourne, D.W. (1990b) HPLC procedure for the pharmacokinetic study of the spin-trapping agent, α-phenyl-N-tert-butyl nitrone (PBN). Free Rad. Biol. Med., 8:93-98.
    • (1990) Free Rad. Biol. Med. , vol.8 , pp. 93-98
    • Chen, G.1    Griffin, M.2    Poyer, J.L.3    McCay, P.B.4    Bourne, D.W.5
  • 10
    • 0027400449 scopus 로고
    • Distribution of spin-trapping compounds in rat blood and brain: In vivo microdialysis determination
    • Cheng, H., Liu, T., Feurerstein, G., and Barone, F.C. (1993) Distribution of spin-trapping compounds in rat blood and brain: in vivo microdialysis determination. Free Rad. Biol. Med., 14:243-250.
    • (1993) Free Rad. Biol. Med. , vol.14 , pp. 243-250
    • Cheng, H.1    Liu, T.2    Feurerstein, G.3    Barone, F.C.4
  • 11
    • 0027344407 scopus 로고
    • Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism
    • Chiueh, C.C., Miyake, H., and Peng, M. (1993) Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism. Adv. Neurol., 60:251-257.
    • (1993) Adv. Neurol. , vol.60 , pp. 251-257
    • Chiueh, C.C.1    Miyake, H.2    Peng, M.3
  • 12
    • 0029006196 scopus 로고
    • The spin trap reagent α-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones
    • Colado, M.I., and Green, A.R. (1995) The spin trap reagent α-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. Eur. J. Pharmacol., 280:343-346.
    • (1995) Eur. J. Pharmacol. , vol.280 , pp. 343-346
    • Colado, M.I.1    Green, A.R.2
  • 13
    • 0028329215 scopus 로고
    • Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress
    • Cubells, J.F., Rayport, S., Rajendran, G., and Sulzer, D. (1994) Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress. J. Neurosci., 14:2260-2271.
    • (1994) J. Neurosci. , vol.14 , pp. 2260-2271
    • Cubells, J.F.1    Rayport, S.2    Rajendran, G.3    Sulzer, D.4
  • 14
    • 0024507123 scopus 로고
    • Functional consequences following methamphetamine-induced neuronal damage
    • De Vito, M.J., and Wagner, G.C. (1989a) Functional consequences following methamphetamine-induced neuronal damage. Psychopharmacology, 97:432-435.
    • (1989) Psychopharmacology , vol.97 , pp. 432-435
    • De Vito, M.J.1    Wagner, G.C.2
  • 15
    • 0024342811 scopus 로고
    • Methamphetamine-induced neuronal damage: A possible role for free radicals
    • De Vito, M.J., and Wagner, G.C. (1989b) Methamphetamine-induced neuronal damage: a possible role for free radicals. Neuropharmacology, 28:1145-1150.
    • (1989) Neuropharmacology , vol.28 , pp. 1145-1150
    • De Vito, M.J.1    Wagner, G.C.2
  • 16
    • 0027095728 scopus 로고
    • Striatal subrogions are differentially vulnerable to the neurotoxic effects of methamphetamine
    • Eisch, A.J., Gaffney, M., Weihmuller, F.B., O'Dell, S.J., and Marshall, J.F. (1992) Striatal subrogions are differentially vulnerable to the neurotoxic effects of methamphetamine. Brain Res., 598:321-326.
    • (1992) Brain Res. , vol.598 , pp. 321-326
    • Eisch, A.J.1    Gaffney, M.2    Weihmuller, F.B.3    O'Dell, S.J.4    Marshall, J.F.5
  • 17
    • 0028833356 scopus 로고
    • Role of hypothermia in mechanism of protection against serotonergic toxicity. 1. Experiments using 3,4-methylenedioxymethamphetamine, dizocilipine, CGS 19755 and NBQX
    • Farfel, G.M., and Seiden, L.S. (1995a) Role of hypothermia in mechanism of protection against serotonergic toxicity. 1. Experiments using 3,4-methylenedioxymethamphetamine, dizocilipine, CGS 19755 and NBQX. J. Pharmacol. Exp. Ther., 272:860-867.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 860-867
    • Farfel, G.M.1    Seiden, L.S.2
  • 18
    • 0028835738 scopus 로고
    • Role of hypothermia in the mechanism of protection against serotonergic neurotoxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextrometorphan
    • Farfel, G.M., and Seiden, L.S. (1995b) Role of hypothermia in the mechanism of protection against serotonergic neurotoxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextrometorphan. J. Pharmacol. Exp. Ther., 272:868-875.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 868-875
    • Farfel, G.M.1    Seiden, L.S.2
  • 19
    • 0026647763 scopus 로고
    • Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress
    • Floyd, R.A., and Carney, J.M. (1992) Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol., 32:S22-S27.
    • (1992) Ann. Neurol. , vol.32
    • Floyd, R.A.1    Carney, J.M.2
  • 20
    • 0028947076 scopus 로고
    • Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: Impact of methamphetamine
    • Giovanni, A., Liang, L.P., Hastings, T.G., and Zigmond, M.J. (1995) Estimating hydroxyl radical content in rat brain using systemic and intraventricular salicylate: impact of methamphetamine. J. Neurochem., 64:1819-1825.
    • (1995) J. Neurochem. , vol.64 , pp. 1819-1825
    • Giovanni, A.1    Liang, L.P.2    Hastings, T.G.3    Zigmond, M.J.4
  • 21
    • 0018148688 scopus 로고
    • Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro
    • Graham, D.G., Tiffany, S.M., Bell, W.R., and Gutknecht, W.F. (1978) Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol. Pharmacol., 14: 644-653.
    • (1978) Mol. Pharmacol. , vol.14 , pp. 644-653
    • Graham, D.G.1    Tiffany, S.M.2    Bell, W.R.3    Gutknecht, W.F.4
  • 22
    • 0026511426 scopus 로고
    • The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: Evidence for the protective effect of chlormethiazole
    • Green, A.R., De Souza, R.J., Williams, J.L., Murray, T.K., and Cross, A.J. (1992) The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole. Neuropharmacology, 31:315-321.
    • (1992) Neuropharmacology , vol.31 , pp. 315-321
    • Green, A.R.1    De Souza, R.J.2    Williams, J.L.3    Murray, T.K.4    Cross, A.J.5
  • 23
    • 0028986577 scopus 로고
    • Methamphetamine-induced serotonin neurotoxicity is mediated by superoxide radicals
    • Hirata, H., Ladenheim, B., Rothman, R.B., Epstein, C., and Cadet, J.L. (1995) Methamphetamine-induced serotonin neurotoxicity is mediated by superoxide radicals. Brain Res., 677:345-347.
    • (1995) Brain Res. , vol.677 , pp. 345-347
    • Hirata, H.1    Ladenheim, B.2    Rothman, R.B.3    Epstein, C.4    Cadet, J.L.5
  • 24
    • 0018853937 scopus 로고
    • Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain
    • Hotchkiss, A.J., and Gibb, J.W. (1980) Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain. J. Pharmacol. Exp. Ther., 214: 257-262.
    • (1980) J. Pharmacol. Exp. Ther. , vol.214 , pp. 257-262
    • Hotchkiss, A.J.1    Gibb, J.W.2
  • 25
    • 0018574520 scopus 로고
    • The long-term effects of multiple doses of methamphetamine on neostriatal tryptophan hydroxylase, tyrosine hydroxylase, choline acetyltransferase and glutamate decarboxylase activities
    • Hotchkiss, A.J., Morgan, M.E., and Gibb, J.W. (1979) The long-term effects of multiple doses of methamphetamine on neostriatal tryptophan hydroxylase, tyrosine hydroxylase, choline acetyltransferase and glutamate decarboxylase activities. Life Sci., 25:1373-1378.
    • (1979) Life Sci. , vol.25 , pp. 1373-1378
    • Hotchkiss, A.J.1    Morgan, M.E.2    Gibb, J.W.3
  • 26
    • 33947300042 scopus 로고
    • Detection and identification of short-lived free radicals by electron spin resonance trapping techniques (spin trapping). Photolysis of organolead, -tin, and -mercury compounds
    • Janzen, E.G., and Blackburn, B.J. (1969) Detection and identification of short-lived free radicals by electron spin resonance trapping techniques (spin trapping). Photolysis of organolead, -tin, and -mercury compounds. J. Am. Chem. Soc., 91:4481-4490.
    • (1969) J. Am. Chem. Soc. , vol.91 , pp. 4481-4490
    • Janzen, E.G.1    Blackburn, B.J.2
  • 27
    • 0025163202 scopus 로고
    • 4-induced rat liver injury detected by proton magnetic resonance imaging (MRI) in vivo and electron micropsy (EM)
    • 4-induced rat liver injury detected by proton magnetic resonance imaging (MRI) in vivo and electron micropsy (EM). Free Radic. Res. Commun., 9:325-335.
    • (1990) Free Radic. Res. Commun. , vol.9 , pp. 325-335
    • Janzen, E.G.1    Towner, R.A.2    Yamashiro, S.3
  • 28
    • 0026794445 scopus 로고
    • Cardiotoxicity induced by doxorubicin in vivo: Protective activity of the spin trap alpha-phenyl-tert-butyl nitrone
    • Jotti, A., Paracchini, L., Perletti G., and Piccinini, F. (1992) Cardiotoxicity induced by doxorubicin in vivo: protective activity of the spin trap alpha-phenyl-tert-butyl nitrone. Pharmacol. Res., 26:143-149.
    • (1992) Pharmacol. Res. , vol.26 , pp. 143-149
    • Jotti, A.1    Paracchini, L.2    Perletti, G.3    Piccinini, F.4
  • 29
    • 0028326176 scopus 로고
    • In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: Potential molecular targets of chemical teratogenesis
    • Liu, L., and Wells, P.G. (1994) In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis. Toxicol. Appl. Pharmacol., 125:247-255.
    • (1994) Toxicol. Appl. Pharmacol. , vol.125 , pp. 247-255
    • Liu, L.1    Wells, P.G.2
  • 31
    • 0027964301 scopus 로고
    • Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse
    • Miller, D.B., and O'Callaghan, J.P. (1994) Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. J. Pharmacol. Exp. Ther., 270:752-760.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 752-760
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 32
    • 0026180539 scopus 로고
    • Assessment of neurotoxicity: Use of glial fibrillary acidic protein as a biomarker
    • O'Callaghan, J.P. (1991) Assessment of neurotoxicity: use of glial fibrillary acidic protein as a biomarker. Biomed. Environ. Sci., 4:197-206.
    • (1991) Biomed. Environ. Sci. , vol.4 , pp. 197-206
    • O'Callaghan, J.P.1
  • 33
    • 0025088070 scopus 로고
    • Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN)
    • Phillis, J.W., and Clough-Helfman, C. (1990) Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN). Neurosci. Lett., 116:315-319.
    • (1990) Neurosci. Lett. , vol.116 , pp. 315-319
    • Phillis, J.W.1    Clough-Helfman, C.2
  • 34
    • 0027403536 scopus 로고
    • Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatum
    • Pu, C., and Vorhees, C.V. (1993) Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatum. Dev. Brain Res., 72:325-328.
    • (1993) Dev. Brain Res. , vol.72 , pp. 325-328
    • Pu, C.1    Vorhees, C.V.2
  • 35
    • 0028180497 scopus 로고
    • The effects of amfonelic acid, a dopamine uptake inhibitor, on methamphetamine-induced dopaminergic terminal degeneration and astrocytic response in rat striatum
    • Pu, C., Fisher, J.E., Cappon, G.D., and Vorhees, C.V. (1994) The effects of amfonelic acid, a dopamine uptake inhibitor, on methamphetamine-induced dopaminergic terminal degeneration and astrocytic response in rat striatum. Brain Res., 649:217-224.
    • (1994) Brain Res. , vol.649 , pp. 217-224
    • Pu, C.1    Fisher, J.E.2    Cappon, G.D.3    Vorhees, C.V.4
  • 36
    • 0020084295 scopus 로고
    • Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain
    • Ricaurte, G.A., Guillery, R.W., Seiden, L.S., Schuster, C.R., and Moore, R.Y. (1982) Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain. Brain Res., 235: 93-103.
    • (1982) Brain Res. , vol.235 , pp. 93-103
    • Ricaurte, G.A.1    Guillery, R.W.2    Seiden, L.S.3    Schuster, C.R.4    Moore, R.Y.5
  • 39
    • 0017265531 scopus 로고
    • Long term methamphetamine induces changes in brain catecholamines in tolerant rhesus monkeys
    • Seiden, L.S., Fischman, M.W., and Schuster, C.R. (1976) Long term methamphetamine induces changes in brain catecholamines in tolerant rhesus monkeys. Drug Alcohol Depend., 1:215-219.
    • (1976) Drug Alcohol Depend. , vol.1 , pp. 215-219
    • Seiden, L.S.1    Fischman, M.W.2    Schuster, C.R.3
  • 40
    • 0027433560 scopus 로고
    • Alpha-phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischemia-reperfusion injury of the rat brain: An EPR study
    • Sen, S., and Phillis, J.W. (1993) Alpha-phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischemia-reperfusion injury of the rat brain: an EPR study. Free Radic. Res. Commun., 19:255-265.
    • (1993) Free Radic. Res. Commun. , vol.19 , pp. 255-265
    • Sen, S.1    Phillis, J.W.2
  • 41
    • 0022398587 scopus 로고
    • Hydroxyl radical attack on dopamine
    • Slivka, A., and Cohen, G. (1985) Hydroxyl radical attack on dopamine. J. Biol. Chem., 260:15466-15472.
    • (1985) J. Biol. Chem. , vol.260 , pp. 15466-15472
    • Slivka, A.1    Cohen, G.2
  • 42
    • 0023131941 scopus 로고
    • Tyrosine hydroxylase immunochemistry and quantitative light microscopic studies of the mesolimbic dopamine system in rat brain: Effects of chronic methamphetamine administration
    • Trulson, M.E., Cannon, M.S., Faegg, T.S., and Raese, J.D. (1987) Tyrosine hydroxylase immunochemistry and quantitative light microscopic studies of the mesolimbic dopamine system in rat brain: effects of chronic methamphetamine administration. Brain Res. Bull., 18:269-277.
    • (1987) Brain Res. Bull. , vol.18 , pp. 269-277
    • Trulson, M.E.1    Cannon, M.S.2    Faegg, T.S.3    Raese, J.D.4
  • 43
    • 0018881202 scopus 로고
    • Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine
    • Wagner, G.C., Ricaurte, G.A., Seiden, L.S., Schuster, C.R., Miller, R.J., and Westley, J. (1980) Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. Brain Res., 181:151-160.
    • (1980) Brain Res. , vol.181 , pp. 151-160
    • Wagner, G.C.1    Ricaurte, G.A.2    Seiden, L.S.3    Schuster, C.R.4    Miller, R.J.5    Westley, J.6
  • 44
    • 0021914474 scopus 로고
    • Pretreatment with ascorbic acid attenuates the neurotoxic effects of methamphetamine in rats
    • Wagner, G.C., Carelli, R.M., and Jarvis, M.F. (1985) Pretreatment with ascorbic acid attenuates the neurotoxic effects of methamphetamine in rats. Res. Comm. Chem. Pathol. Pharm., 47:221-228.
    • (1985) Res. Comm. Chem. Pathol. Pharm. , vol.47 , pp. 221-228
    • Wagner, G.C.1    Carelli, R.M.2    Jarvis, M.F.3
  • 45
    • 0026522028 scopus 로고
    • Neuroprotective effect of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons
    • Yue, T., Gu, J., Lysko, P.G., Chen, H., Barone, F.C., and Feuerstein, G. (1992) Neuroprotective effect of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res., 574:193-197.
    • (1992) Brain Res. , vol.574 , pp. 193-197
    • Yue, T.1    Gu, J.2    Lysko, P.G.3    Chen, H.4    Barone, F.C.5    Feuerstein, G.6


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