Dietary fish oil inhibits the expression of farnesyl protein transferase and colon tumor development in rodents

Carcinogenesis

Volumn 19, Issue 6, 1998, Pages 985-989

  Singh, Jagveer ^a   Hamid, Rachid ^a   Reddy, Bandaru S ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORN OIL; FISH OIL; OMEGA 3 FATTY ACID; ONCOPROTEIN; POLYUNSATURATED FATTY ACID; PROTEIN FARNESYLTRANSFERASE; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON CARCINOGENESIS; COLON TUMOR; CONTROLLED STUDY; DIET SUPPLEMENTATION; FAT INTAKE; GENE EXPRESSION REGULATION; MALE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; RAT;

ALKYL AND ARYL TRANSFERASES; ANIMALS; AZOXYMETHANE; BLOTTING, WESTERN; BODY WEIGHT; CARCINOGENS; COLONIC NEOPLASMS; DIETARY FATS; FISH OILS; RATS; RATS, INBRED F344;

EID: 0031878589     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.6.985     Document Type: Article

References (32)

1. Parker,S.L., Tong,T., Bolden,S. and Wingo,P.A. (1997) Cancer statistics, 1997. CA-A Cancer J. Clin., 47, 5-27.
2. Giovannucci,E. and Willett, W.C. (1994) Dietary factors and risk of colon cancer. Ann. Med., 26, 443-452.
3. Caygill,C.P.J., Charlett,A. and Hill,M.J. (1996) Fat, fish, fish oil and cancer. Br. J. Cancer. 74, 159-164.
4. Reddy,B.S. (1996) Dietary lipids and colon cancer. In Spiller,G.A. (ed.) Handbook of Lipids in Human Nutrition. CRC Press, Boca Raton, FL, pp. 129-134.
5. Torosian,M.H., Charland,S.L. and Lippin,J.A. (1995) Differential effects of omega-3 and omega-6 fatty acids on primary tumor growth and metastasis. Int. J. Oncol., 7, 667-672,
6. Kremer,J.M., Jubiz,M.A., Rynes,R.I., Bartholomew,L.E., Bigaouette,J., Timchalk,M., Beeler,D. and Lininger,L. (1987) Fish oil fatty acid supplementation in active rheumatoid arthritis: a double-blind, controlled, cross-over study. Ann. Intern. Med., 106, 497-503.
7. Bittiner,S.B., Tucker,W.F., Cartwright,I. and Bleehan,S.S. (1988) A double-blind, randomized, placebo-controlled trial of fish oil in psoriasis. Lancet, 2, 117-119.
8. Dolecek,T.A. and Granditis,G. (1991) Dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial (MRFIT). World Rev. Nutr. Diet, 66, 205-216.
9. Corey,R.J., Shih,C. and Cashman,J.R. (1983) Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proc. Natl Acad. Sci. USA, 80, 3581-3584.
10. Culp,B.R., Titus,B.J. and Lands,W.E. (1979) Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid. Prostaglandin Med., 3, 269-278.
11. Reddy,B.S., Simi,B., Patel,N., Aliaga,C. and Rao,C.V. (1996) Effect of amount and types of dietary fat on intestinal bacterial 7-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonie mucosal diacylglycerol kinase and PKC activities during different stages of colon tumor promotion. Cancer Res., 56, 2314-2320.
12. Bishop,J.M. (1989) The molecular genetics of cancer. Science (Washington DC), 235, 305-311.
13. Egan,S.E. and Weinberg,R.A. (1993) The pathway to signal achievement. Nature (Lond.), 365, 781-783.
14. Barbacid,M. (1990) Ras oncogenes: their role in neoplasia. Eur. J. Clin. Invest., 20, 225-235.
15. Lowy,D.R. and Willumsen,B.M. (1993) Function and regulation of ras. Ann. Rev. Biochem., 62, 851-891.
16. Stacey,D.W., Feig,L.A. and Gibbs,J.B. (1991) Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras. Mol Cell. Biol., 11, 4053-4064.
17. Gibbs,J.B., Oliff,A. and Kohl,N.E. (1994) Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell, 77, 175-178.
18. Kohl,N.E., Wilson,F.R., Mosser,S.D., et al. (1994) Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Prac. Natl Acad. Sci. USA, 91, 9141-9145.
19. Kohl,N.E., Omer,C.A., Conner,M.W., et al. (1995) Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Med., 1, 792-797.
20. Singh,J., Rachid,H. and Reddy,B.S. (1997) Dietary fat and colon cancer: modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer Cancer Res., 57, 253-258.
21. Thompson,N.L., Mead,J.E., Braun,L., Goyette,M., Shank,P.R. and Fausto,N. (1986) Sequential protooncogene expression expression during rat liver regeneration. Cancer Res., 46, 3111-3117.
22. Omer,C.A., Kral,A.M., Diehl,R.E., Prendergast,G.C., Powers,S., Allen,C.M., Gibbs,J.B. and Kohl,N.E. (1993) Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenylprotein transferses. Biochemistry, 32, 5167-5176.
23. Pompliano,D.L., Rands,E., Schaber,M.D., Mosser,S.D., Anthony,N.J. and Gibbs,J.B. (1992) Steady-state kinetic mechanism of Ras farnesyl:protein transferase. Biochemistry, 31, 3800-3807.
24. Seabra,M.C., Reiss,Y., Casey,P.J., Brown,M.S. and Goldstein,J.L. (1991) Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit. Cell, 65, 429-434.
25. Weinstein,I.B. (1988) Strategies for inhibiting multistage carcinogenesis based on signal transduction pathways. Mutat. Res., 202, 413-420.
26. Crews,C.M. and Erickson.R.L. (1993) Extracellular signals and reversible protein phosphorylation: what to make of it all. Cell, 74, 215-217.
27. Der,C.J. and Cox,A.D.(1991) Isoprenoid modification and plasma membrane associations: Critical factors for ras oncogenicity. Cancer Cells, 3, 331-340.
28. Gibbs,J.B. (1991) Ras C-terminal processing enzymes - new drug targets? Cell. 65, 1-4.
29. El-Sohemy,A. and Archer,M.C. (1997) Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids. Cancer Res., 57, 3685-3687.
30. Cox,A.D. and Der,C.J. (1992) The ras/cholesterol connection: Implications for ras oncogenicity. Crit. Rev. Oncogen., 3, 365-400.
31. Kelloff,G.J., Lubet,R.A., Fay,J.R., Steele,V.E., Boone,C.W., Crowell,J.A. and Sigman,C.C.(1997) Farnesyl protein transferase inhibitors as potential cancer chemopreventives (review). Cancer Epidemiol. Biomarkers Prev., 6, 267-282.
32. Rowell,C.A., Kowalczyk,J.J., Lewis,M.D. and Garcia,A.M. (1997) Direct demonstration of geranylgeranylation and famesylation of Ki-ras in vivo. J. Biol. Chem., 272, 14093-14097.