Behavioral effects of vigabatrin correlated with whole brain γ- aminobutyric acid metabolism in audiogenic sensitive rats

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 7, 1998, Pages 713-716

  Engelborghs, Sebastiaan ^a   Pickut, Barbara Anne ^a   D'Hooge, Rudi ^a   Wiechert, Peter ^b   Haegele, Klaus ^c   De Deyn, Peter Paul ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c SANOFI   (France)

Author keywords

Aminobutyric acid; Vinyl aminobutyric acid; Anticonvutsant; Behavioral effects; CAS 60643 86 9; Rat; Vigabatrin

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; VIGABATRIN;

4 AMINOBUTYRIC ACID BRAIN LEVEL; 4 AMINOBUTYRIC ACID METABOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; BRAIN METABOLISM; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT;

4-AMINOBUTYRATE TRANSAMINASE; ACOUSTIC STIMULATION; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; MALE; RATS; RATS, WISTAR; SEIZURES; VIGABATRIN;

EID: 0031876613     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Schechter, P. J., in: New Anticonvulsant Drugs, B. S. Meldrum, R. J. Porter (eds.), p. 265, John Libbey & Co., London (1986)
2. Jung, M. J., Lippert, B., Metcalf, B. W. et al., J. Neurochem. 29, 797 (1977)
3. Schechter, P. J., Br. J. Clin. Pharmacol. 27 (Suppl. 1), 19S (1989)
4. Petroff, O. A., Rothman, D. L., Behar, K. L. et al., Epilepsia 36, 457 (1995)
5. Schechter, P. J., Tranier, Y., Jung, M. J. et al., Eur. J. Pharmacol. 45, 319 (1977)
6. Meldrum, B. S., in: Handbook of Experimental Pharmacology: Antiepileptic Drugs, M. M. Frey, D. Hanz (eds.), p. 153, Springer-Verlag, Berlin (1985)
7. Mumford, J. P., Dam, M., Br. J. Clin. Pharmacol. 27 (Suppl. 1), 101S (1989)
8. French, J. A., Mosier, M., Walker, S. et al., Neurology 46, 54 (1996)
9. Dichter, M. A., Brodie, M. J., N. Engl. J. Med. 334, 1583 (1996)
10. Fowler, L. J., J. Neurochem. 21, 437 (1973)
11. Anzelark, G., Horton, R. W., Meldrum, B. S. et al., Biochem. Pharmacol 25, 413 (1976)
12. Schechter, P. J., Tranier, Y., in: Enzyme-activated Irreversible Inhibitors, N. Seiler, M. J. Jung, J. Koch-Weser (eds.), p. 149, Elsevier/North-Holland Press, Amsterdam (1978)
13. Fletcher, A., Fowler, L. J., Biochem. Pharmacol. 29, 1451 (1980)
14. Valdizán, E. M., Armijo, J. A., Epilepsia 32, 735 (1991)
15. Qume, M., Fowler, L. J., Biochem. Pharmacol. 52, 1355 (1996)
16. Wiechert, P., Göllnitz, G., J. Neurochem. 15, 1265 (1968)
17. Bernasconi, R., Klein, M., Martin, P. et al., J. Neural Transm. 72, 213 (1988)
18. Bolton, J. B., Rimmer, E., Williams, J. et al., Br. J. Clin. Pharmacol. 27 (Suppl. 1), 34S (1989)
19. Jacob, J. N., Hesse, G. W. Shashoua, V. E., J. Med. Chem. 33, 733 (1990)
20. Valdizán, E. M., Armijo, J. A., Biochem. Pharmacol. 43, 2143 (1992)
21. Perry, T. L., Kish, S. J., Hansen, S., J. Neurochem. 32, 1641 (1979)
22. Fowler, L. J., John, R. A., Biochem. J. 130, 569 (1972)
23. Lippert, B., Metcalf, B. W., Jung, M. J. et al., Eur. J. Biochem. 74, 441 (1977)
24. Löscher, W., Biochem. Pharmacol. 31, 837 (1982)
25. Porter, T. G., Martin, D. L., J. Neurochem. 43, 1464 (1984)
26. Pitkänen, A., Matilainen, R., Ruutiainen, T. et al., J. Neurol. Neurosurg. Psychiatry 51, 1395 (1988)
27. Riekkinen, P. J., Ylinen, A., Halonen, T. et al., Br. J. Clin. Pharmacol. 27, 87S (1989)
28. Halonen, T., Pitkänen, A., Saano, V. et al., Epilepsia 32, 242 (1991)
29. Ben-Menachem. E., Persson, L. I., Hamberger, A. et al., Epilepsia 27, 649 (1986)
30. Halonen, T., Lehtinen, M., Pitkänen, A. et al., Epilepsy Res. 2, 246 (1988)