Identification and immunohistochemical localization of protein precursors to human axillary odors in apocrine glands and secretions

Archives of Dermatology

Volumn 134, Issue 7, 1998, Pages 813-818

  Spielman, Andrew I ^a,b   Sunavala, Gulshan ^a,e   Harmony, Judith A K ^d   Stuart, William D ^d   Leyden, James J ^b,c   Turner, Gloria ^a   Vowels, Benjamin R ^c   Lam, Wan C ^a   Yang, Shinjun ^c   Preti, George ^b,c  

^a NEW YORK UNIVERSITY   (United States)

^b MONELL CHEMICAL SENSES CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 2 HEXENOIC ACID; CELL PROTEIN; CLUSTERIN; GLYCOPROTEIN; ODOR BINDING PROTEIN 1; ODOR BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; AMINO TERMINAL SEQUENCE; APOCRINE GLAND; ARTICLE; AXILLA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NORMAL HUMAN; ODOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS;

ADULT; AMINO ACID SEQUENCE; ANTIBODIES; APOCRINE GLANDS; AXILLA; BLOTTING, WESTERN; CLUSTERIN; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; ODORS; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RECEPTORS, ODORANT; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SEX FACTORS;

EID: 0031874974     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.134.7.813     Document Type: Article

References (21)

1. Shehadeh N, Kligman AM. The bacteria responsible for apocrine odor, II. J Invest Dermatol. 1963;41:1-5.
2. Shehadeh N, Kligman AM. The effect of topical antibacterial agents on the bacterial flora of the axilla. J Invest Dermatol. 1963;40:61-71.
3. Gower DB, Holland KT, Mallet AI, Rennie PJ, Watkins WJ. Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora: a mechanism for axillary odour production in man? J Steroid Biochem Mol Biol. 1994;48:409-418.
4. Gower DB, Ruparelia BA. Olfaction in humans with special reference to odorous 16-androstenes: their occurrence, perception and possible social, psychological and sexual impact. J Endocrinol. 1993;137:167-187.
5. Labows JB, McGinley KJ, Kligman AM. Perspectives on axillary odor. J Soc Cosmet Chem. 1982;34:193-202.
6. Labows JN, Preti G. Human semiochemicals. In: van Toller SN, Dodd GH, eds. Fragrance: The Psychology and Biology of Perfume. New York, NY: Elsevier Science Inc; 1992:69-90.
7. Zeng XN, Leyden JJ, Lawley HJ, Sawano K, Nohara I, Preti G. Analysis of characteristic odors from human male axillae. J Chem Ecol. 1991;17:1469-1492.
8. Zeng X-N, Leyden JJ, Brand JG, Spielman AI, McGinley K, Preti G. An investigation of human apocrine gland secretion for axillary odor precursors. J Chem Ecol. 1992;18:1039-1055.
9. Baydar AE, Petrzilka M, Schott M-P. Perception of characteristic axillary odors. Perfumer Flavorist. 1992;17:2-9.
10. Wysocki CJ, Beauchamp GK. Ability to smell androstenone is genetically determined. Proc Natl Acad Sci U S A. 1984;81:4899-4902.
11. Wysocki CJ, Zeng X-N, Preti G. Specific anosmia and olfactory sensitivity to 3-methyl-2-hexenoic acid: a major component of human axillary odor. Chem Senses. 1993;18:652-653.
12. Spielman AI, Zeng X-N, Leyden JJ, Preti G. Proteinaceous precursors of human axillary odor: isolation of two novel odor-binding proteins. Experientia. 1995;51:40-47.
13. Zeng C, Spielman AI, Vowels BR, Leyden JJ, Biemann K, Preti G. A human axillary odorant is carried by apolipoprotein D. Proc Natl Acad Sci U S A. 1996;93:6626-6630.
14. de Silva HV, Stuart WD, Park YB, et al. Purification and characterization of apolipoprotein J. J Biol Chem. 1990;265:14292-14297.
15. Aronow BJ, Lund SD, Brown TL, Harmony JAK, Witte DP. Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection. Proc Natl Acad Sci U S A. 1993;90:725-729.
16. Jordan-Starck TC, Witte DP, Aronow BJ, Harmony JAK. Apolipoprotein J: a membrane policeman? Curr Opin Lipidol. 1993;3:375-385.
17. Grosvenor W, Spielman AI, Feigin AI, et al. Purification of an arginine taste receptor from the channel catfish. Chem Senses. 1996;21:610.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of a bacteriophage T4. Nature. 1970;227:680-685.
20. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979;76:4350-4354.
21. Zeng X-N, Leyden JJ, Spielman AI, Preti G. Analysis of the characteristic human female odors: qualitative comparison to males. J Chem Ecol. 1996;22:237-257.