3-Hydroxyphthaloyl-β-lactoglobulin. I. Optimization of production and comparison with other compounds considered for chemoprophylaxis of mucosally transmitted human immunodeficiency virus type 1

Antiviral Chemistry and Chemotherapy

Volumn 8, Issue 2, 1997, Pages 131-139

  Neurath, A R ^a   Debnath, A K ^a   Strick, N ^a   Li, Y Y ^a   Lin, K ^a   Jiang, S ^a  

^a NEW YORK BLOOD CENTER   (United States)

Author keywords

3 hydroxyphthalic anhydride; bovine lactoglobulin; CD4; HIV; prophylaxis

Indexed keywords

BETA LACTOGLOBULIN; CD4 ANTIGEN; DEXTRAN SULFATE; POLYSACCHARIDE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG MANUFACTURE; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROPHYLAXIS; SEXUAL TRANSMISSION; VIRUS TRANSMISSION;

EID: 0031052759     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029700800207     Document Type: Article

References (23)

1. Bird KD (1991) The use of spermicide containing nonoxynol-9 in the prevention of HIV infection. AIDS 5: 791-796.
2. Cho Y, Gu W, Watkins S, Lee S-P, Kim T-R, Brady JW & Batt CA (1994) Thermostable variants of bovine β-lactoglobulin. Protein Engineering 7: 263-270.
3. De Clercq E (1995) Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. Journal of Medicinal Chemistry 38: 2491-2517.
4. De Wit JN & Swinkels GAM (1980) A differential scanning calorimetric study of the thermal denaturation of bovine β-lactoglobulin. Thermal behaviour at temperatures up to 100°C. Biochimica et Biophysica Acta 624: 40-50.
5. Dong A, Matsuura J, Allison SD, Chrisman E, Manning MC & Carpenter JF (1996) Infrared and circular dichroism spectroscopic characterization of structural differences between β-lactoglobulin A and B. Biochemistry 35: 1450-1457.
6. Iametti S, De Gregori B, Vecchio G & Bonomi F (1996) Modifications occur at different structural levels during the heat denaturation of β-lactoglobulin. European Journal of Biochemistry 237: 106-112.
7. Jiang S, Lin K, Strick N & Neurath AR (1993) HIV-1 inhibition by a peptide. Nature 365: 113.
8. McAlpine AS & Sawyer L (1990) β-lactoglobulin: a protein drug carrier? Biochemical Society Transactions 18: 879.
9. Mitsuya H, Looney DJ, Kuno S, Ueno R, Wong-Staal F & Broder S (1988) Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. Science 240: 646-649.
10. Mitsuya H, Yarchoan R & Broder S (1990) Molecular targets for AIDS therapy. Science 249: 1533-1544.
11. Moore JP (1990) Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4. AIDS 4: 297-305.
12. Moore JP, McKeating JA, Jones IM, Stephens PE, Clements G, Thomson S & Weiss RA (1990) Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4. AIDS 4: 307-315.
13. Moore JP, Simpson G, McKeating JA, Burakoff SJ, Schreiber SL & Weiss RA (1992) CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro. Virology 188: 537-544.
14. Neurath AR, Strick N, Haberfield P & Jiang S (1992) Rapid prescreening for antiviral agents against HIV-1 based on their inhibitory activity in site-directed immunoassays. II. Porphyrins reacting with the V3 loop of gp120. Antiviral Chemistry and Chemotherapy 3: 55-63.
15. Neurath AR, Debnath AK, Strick N, Li Y-Y, Lin K & Jiang S (1995a) Blocking of CD4 cell receptors for the human immunodeficiency virus type 1 (HIV-1) by chemically modified bovine milk proteins: potential for AIDS prophylaxis. Journal of Molecular Recognition 8: 304-316
16. Neurath AR, Strick N & Debnath AK (1995b) Structural requirements for and consequences of an antiviral porphyrin binding to the V3 loop of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp120. Journal of Molecular Recognition 8: 345-357.
17. Neurath AR, Jiang S, Strick N, Lin K, Li Y-Y & Debnath AK (1996a) Bovine β-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV. Nature Medicine 2: 230-234.
18. Neurath AR, Li Y-Y, Strick N & Jiang S (1996b) A herpesvirus inhibitor prepared from bovine whey. Lancet 347: 1703-1704.
19. Pauwels R & De Clercq E (1996) Development of vaginal microbicides for the prevention of heterosexual transmission of HIV. AIDS Reaerch and Human Retroviruses 11: 211-221.
20. Poignard P, Fouts T, Naniche D, Moore JP St Sattentau QI (1996) Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation. Journal of Experimental Medicine 183: 473-484.
21. Qi XL, Brownlow S, Holt C & Sellers P (1995) Thermal denaturation of β-lactoglobulin: effect of protein concentration at pH 6.75 and 8.05. Biochimica et Biophysica Acta 1248: 43-49.
22. Reddy IM, Kella NKD & Kinsella JE (1988) Structural and conformational basis of the resistance of β-lactoglobulin to peptic and chymotryptic digestion. Journal of Agricultural and Food Chemistry 36: 737-741.
23. Swart PJ, Kuipers ME, Smit C, Pauwels R, De Béthune MP, De Clercq E, Meijer DKF & Huisman JG (1996) Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro. AIDS Research and Human Retroviruses 12: 769-775.