DNA replication is completed in Saccharomyces cerevisiae cells that lack functional Cdc14 a dual-specificity protein phosphatase

Molecular and General Genetics

Volumn 258, Issue 4, 1998, Pages 437-441

  Fitzpatrick, P J ^a   Toyn, J H ^a,b   Millar, J B A ^a   Johnston, L H ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b DUPONT COMPANY   (United States)

Author keywords

DNA synthesis; Dual specificity phosphatase; Saccharomyces cerevisiae; Telophase

Indexed keywords

CELL CYCLE PROTEIN; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR;

ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME INACTIVATION; FUNGAL GENETICS; GENE OVEREXPRESSION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PULSED FIELD GEL ELECTROPHORESIS; SACCHAROMYCES CEREVISIAE; TELOPHASE;

CELL CYCLE PROTEINS; CLONING, MOLECULAR; DNA REPLICATION; DNA, FUNGAL; ENZYME INHIBITORS; FUNGAL PROTEINS; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE;

SACCHAROMYCES CEREVISIAE;

EID: 0031865933     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050753     Document Type: Article

References (19)

1. Culotti J, Hartwell LH (1971) Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division. Exp Cell Res 67:389-401
2. Deshaies RJ (1997) Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast. Curr Opin Genet Dev 7:7-16
3. SDB25 a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8:1640-1653
4. Gietz RD, Sugino A (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534
5. Hardy CF (1996) Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol Cell Biol 16:1832-1841
6. Hartwell LH, Smith D (1985) Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110:381-395
7. Hartwell LH, Mortimer RK, Culotti J, Culotti M (1973) Genetic control of the cell division cycle in yeast: V. Genetic analysis of cdc mutants. Genetics 74:267-286
8. Hennessy KM, Lee A, Chen E, Botstein D (1991) A group of interacting yeast DNA replication genes. Genes Dev 5:958-969
9. Johnston LH, Eberly SL, Chapman JW, Araki H, Sugino A (1990) The product of the Saccromyces cerevisiae cell cycle gene DBF2 has homology with protein kinase and is periodically expressed in the cell cycle. Mol Cell Biol 10:1358-1366
10. Kroll ES, Hyland KM, Hieter P, Li JJ (1996) Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143:95-102
11. Liang C, Weinreich M, Stillman B (1995) ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81:667-676
12. Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259:216-219
13. Palmer RE, Hogan E, Koshland D (1990) Mitotic transmission of artificial chromosomes in cdc mutants of the yeast, Saccharomyces cerevisiae. Genetics 125:763-774
14. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
15. Shirayama M, Matsui Y, Toh-e A (1994) The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Mol Cell Biol 14:7476-7482
16. Shirayama M, Matsui Y, Toh-e A (1996) Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14. Mol Gen Genet 251:176-185
17. Taylor GS, Liu Y, Baskerville C, Charbonneau H (1997) The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem 272:24054-24063
18. Toyn JH, Johnston LH (1993) Spo12 is a limiting factor that interacts with the cell cycle protein kinases Dbf2 and Dbf20, which are involved in mitotic chromatid disjunction. Genetics 135:963-971
19. Toyn JH, Johnson AL, Donovan JD, Toone WM, Johnston LH (1997) The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase. Genetics 145:85-96