Co-stimulation of T cells with CD2 augments TCR-CD3-mediated activation of protein tyrosine kinase p72(syk), resulting in increased tyrosine phosphorylation of adapter proteins, Shc and Cbl

International Immunology

Volumn 10, Issue 6, 1998, Pages 833-845

  Umehara, Hisanori ^a   Huang, Jian Yong ^a   Kono, Takeshi ^b   Tabassam, Fazal H ^a   Okazaki, Toshiro ^c   Gouda, Seiji ^a   Nagano, Yutaka ^a   Bloom, Eda T ^d   Domae, Naochika ^a  

^a OSAKA DENTAL UNIVERSITY   (Japan)

^b NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Adapter protein; CD2; Cellular activation; Co stimulatory molecules; Protein kinase; Signal transduction; T lymphocytes; TCR

Indexed keywords

ADAPTOR PROTEIN; CD2 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 2; MYELIN BASIC PROTEIN; PHYTOHEMAGGLUTININ; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ASSAY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANTIGENS, CD2; ANTIGENS, CD3; BACTERIAL PROTEINS; COLICINS; ENZYME PRECURSORS; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; T-LYMPHOCYTES;

EID: 0031864501     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.6.833     Document Type: Article

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