DNA adduct formation in human and rat mammary epithelium by N-hydroxy derivatives of 2-aminofluorene and 4-aminobiphenyl

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 18, Issue 1, 1998, Pages 35-39

  Debiec Rychter, Maria ^a   Tada, Mariko ^b   Poirier, Miriam C ^c   Wang, Ching Y ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

2 aminofluorene; 4 aminobiphenyl; DNA adduct; Human; Mammary epithelium; N acetyltransferase; Rat

Indexed keywords

2 FLUORENYLAMINE; 4 BIPHENYLAMINE; PARAOXON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; CELL CULTURE; CONTROLLED STUDY; DNA ADDUCT; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINOBIPHENYL COMPOUNDS; ANIMALS; BREAST; CELLS, CULTURED; DNA ADDUCTS; EPITHELIAL CELLS; FEMALE; FLUORENES; HUMANS; MAMMARY GLANDS, ANIMAL; MUTAGENS; RATS; RATS, INBRED F344;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

EID: 0031863127     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6866(1998)18:1<35::AID-TCM5>3.0.CO;2-F     Document Type: Article

References (20)

1. Garner RC, Martin CN, Layson DB: Carcinogenic aromatic amines and related compounds. In Searle CE (ed): "Chemical Carcinogens." Washington, DC: American Chemical Society, 1984, pp 175-276.
2. King CM, Land SJ, Jones RF, Debiec-Rychter M, Lee M-S, Wang CY: Role of acetyltransferases in the metabolism and carcinogenicity of aromatic amines. Mutation Res 376:123-128, 1997.
3. Allaben WT, Weeks CE, Weis CC, Burger GT, King CM: Rat mammary gland carcinogenesis after local injection of N-hydroxy-N-acyl-2-aminofluorenes: Relationship to metabolic activation. Carcinogenesis 3:233-240, 1982.
4. Allaben WT, Weis CC, Fullerton NF, Belland FA: Formation and persistence of DNA adducts from the carcinogen N-hydroxy-2-acetylaminofluorene in rat mammary gland in vivo. Carcinogenesis 4:1067-1070, 1983.
5. Beland FA, Kadlubar FF: Formation and persistence of arylamine DNA adducts in vivo. Environ Health Perspect 62:19-30, 1985.
6. King CM, Traub NR, Lortz ZM, Thissen MR: Metabolic activation of arylhydroxamic acids by N,O-acetyltransferase of rat mammary gland. Cancer Res 37:111-117, 1979.
7. King CM: Mechanism of reaction, tissue distribution, and inhibition of arylhydroxamic acid acyltransferase. Cancer Res 34:1503-1515, 1974.
8. Sadrieh N, Davis CD, Snyderwine EG: (1996) N-acetyltransferase expression and metabolic activation of the food-derived heterocyclic amines in the human mammary gland. Cancer Res 56:2683-2687, 1996.
9. Wang CY, Yamada H, Morton KC, Zukowski K, Lee M-S, King CM: Induciton of repair synthesis of DNA in mammary and urinary bladder epithelial cells by N-hydroxy derivatives of carcinogenic arylamines. Cancer Res 48:4227-4232, 1988.
10. Tay LK, Russo J: 7, 12-Dimethylbenz(a)anthracene-induced DNA binding and repair synthesis in susceptible and nonsusceptible mammary binding and repair synthesis in susceptible and nonsusceptible mammary epithelial cells in culture. J Natl Cancer Inst 67:155-161, 1981.
11. Wang CY, Morton KC, Lee M-S: Repair synthesis of DNA induced by the urinary N-hydroxy metabolites of carcinogenic arylamines in urothelial cells of susceptible species. Cancer Res 45:221-225, 1985.
12. Debiec-Rychter M, Zukowski K, Tada M, Poirier MC, Wang CY: Removal of arylamine-DNA adducts in epithelial cells of rat and human urinary bladder and mammary gland. Int J Oncology 5:997-1002, 1994.
13. Poirier MC, Connor RJ: A radioimmunoassay for 2-acetylaminofluorene-DNA adducts. Methods in Enzymology 84:607-618, 1982.
14. Tada M, Aoki H, Kojima M, Monta T, Shirai T, Yamada H, Ito N: Preparation and characterization of antibodies against 3,2′-dimethyl-4-aminobiphenyl-modified DNA. Carcinogenesis 10:1397-1402, 1989.
15. Wang CY, Zukowski K, Lee M-S, Sone T: Purification and characterization of rat hepatic microsomal N,O-actyltransferases. Carcinogenesis 13:2017-2020, 1992.
16. Grant DM, Blum M, Beer M, Meyer USA: Monomorphic and polymorphic human arylamine N-acetyltransferases: A comparison of liver isozymes and expressed products of two cloned genes. Mol Pharmacol 39:184-191, 1991.
17. Doll MA, Fretland AJ, Deitz AC, Hein DW: Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification. Anal Biochem 231:413-420, 1995.
18. Risch A, Wallace DM, Bathers S, Sim E: Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. Hum Mol Genet 4:231-236, 1995.
19. Ambrosone CB, Freudenheim JL, Graham S, Marshall JR, Vena JE, Brasure JR, Michalek AM, Laughlin R, Nemoto T, Gillenwater KA, Harrington AM, Shields PG: Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. JAMA 13:1494-1501, 1996.
20. Malejka-Giganti D, Rydell RE: Lack of susceptibility of F344 rats to mammary tumor induction by topically applied fluorenylacetohydroxamic acids and their acetates. J Natl Cancer Inst 60:433-435,1978.