Effects of four years' treatment with biosynthetic human growth hormone (GH) on body composition in GH-deficient hypopituitary adults

European Journal of Endocrinology

Volumn 135, Issue 5, 1996, Pages 559-567

  Al Shoumer, Kamal A S ^a   Page, Brian ^b   Thomas, Elizabeth ^a   Murphy, Margaret ^a   Beshyah, Salem A ^a   Johnston, Desmond G ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; HUMAN GROWTH HORMONE; PLACEBO; SOMATOMEDIN C;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; MALE; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029966834     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1350559     Document Type: Article

References (48)

1. Salomon F, Cuneo RC, Hesp R, Sönksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989;321:1797-803
2. Jørgensen JOL, Pedersen SA, Thuesen L, Jørgensen J, Møller J, Müller J, et al. Long-term growth hormone treatment in growth hormone deficient adults. Acta Endocrinol (Copenh) 1991;125: 449-53
3. De Boer H, Blok GJ, Voerman HJ, De Vries PMJM, van der Veen EA. Body composition in adult growth hormone deficient men, assessed by anthropometry and bioimpedance analysis. J Clin Endocrinol Metab 1992;75:833-7
4. Binnerts A, Swart GR, Wilson JHP, Hoogerbrugge N, Pols HAP, Birkenhäger JC, et al. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol 1992;37:79-87
5. Rosén T, Bosaeus I, Tölli J, Lindstedt G, Bengtsson, B-Å. Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin Endocrinol 1993;38:63-71
6. Markussis V, Beshyah SA, Fisher C, Sharp P, Nicolaides AN, Johnston DG. Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet 1992;340:1188-92
7. Cheek DB, Hill DE. Effect of growth hormone on cell and somatic growth. In: Knobil E, Sawyer CH, editors. Handbook of physiology and endocrinology. Washington, DC: American Physiology Society, 1974:159-85
8. Jørgensen JOL, Pedersen SA, Theusen L, Jørgensen J, Ingemann-Hansen T, Sakkeback NE, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989;1:1221-5
9. Bengtsson B-Å, Eden S, Lönn L, Kvist H, Stokland A, Lindstedt G, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993; 76:309-17
10. Rosén T, Johannsson G, Hallgren P, Caidahl K, Bosaeus I, Bengtsson B-Å. Beneficial effects of 12 months replacement with recombinant human growth hormone to growth hormone deficient adults. Endocrinol Metab 1994;1:55-66
11. Weaver JU, Monson JP, Noonan K, John WG, Edwards A, Evans KA, et al. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. J Clin Endocrinol Metab 1995;80:153-9
12. Collip PJ, Curti V, Thomas J, Sharma RK, Maddaiah VT, Conn SH. Body composition changes in children receiving growth hormone. Metabolism 1973;22:589-95
13. Tanner JM, Hughes PCR, Whitehouse RH. Comparative rapidity of response of height, limb muscle and limb fat to treatment with human growth hormone in patients with and without growth hormone deficiency. Acta Endocrinol (Copenh) 1977;84:681-96
14. Beshyah SA, Henderson A, Niththyananthan R, Skinner E, Anyaoku V, Richmond W, et al. The effects of short and long term growth hormone therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. J Clin Endocrinol Metab 1995;80:356-63
15. Teale JD, Marks V. The measurement of insulin like growth factor I: clinical applications and significance. Ann Clin Biochem 1986;23:413-24
16. Spinks TJ, Bewley DK, Ranicar ASO, Joplin GF. Measurement of total body calcium in bone disease. J Radioanal Chem 1977;37:345-55
17. Boddy K, King PC, Hume R, Weyers E. The relationship of total body potassium to height, weight and age in normal adults. J Clin Pathol 1972;25:512-7
18. Lukaski H, Johnson PE, Bolonchuk WW, Lykken G. Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am J Clin Nutr 1985;41:810-7
19. Kushner RF, Schoeller DA. Estimation of total body water by bioelectrical-impedance analysis. Am J Clin Nutr 1986;44:417-24
20. Pace HV, Rathbun EN. Studies on body composition, body water and chemically combined nitrogen content in relation to fat content. J Biol Chem 1945;158:685-91
21. Hall K, Lundin G, Povoa G. Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosa. Acta Endocrinol (Copenh) 1988;118:321-6
22. Rosén T, Bengtsson B-Å. Premature cardiovascular mortality in hypopituitarism- a study of 333 consecutive patients. Lancet 1990;336:285-8
23. Wüster C, Slenczka E, Ziegler R. Erhöhte Prävalenz von Osteoprose und Arteriosklerose bei konventionell substituierter hypophysenvorderlappen Insuffizienz: Bedraf einer zusätzlichen Wachstumshormonsubstitution? Klinische Wochenschrift 1991;68:769-73
24. Sjöström LV. Morbidity of severely obese subjects. Am J Clin Nutr 1992;55:508S-15S
25. Sjöström LV. Mortality of severely obese subjects. Am J Clin Nutr 1992;55:5168-238
26. Han TS, van Leer EM, Seidell JC, Lean ME. Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample. Br Med J 1995;311:1401-5
27. Jørgensen JOL, Thuesen L, Müller J, Ovesen P, Skakkeback NE, Christiansen JS. Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance. Eur J Endocrinol 1994;130:224-8
28. Chong PKK, Jung RT, Scrimgeour CM, Rennie MJ, Paterson CR. Energy expenditure and body composition in growth hormone deficient adults on exogenous growth hormone. Clin Endocrinol 1994;40:103-10
29. Degerblad M, Elgindy N, Hall K, Sjoberg HE, Thoren, M. Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism. Acta Endocrinol (Copenh) 1992;126:387-93
30. Whitehead HM, Boreham C, McIlrath EM, Sheridan B, Kennedy L, Atkinson AB, et al. Growth hormone treatment of adults with growth hormone deficiency: results of a 13-months placebo controlled cross over study. Clin Endocrinol 1992;36:45-52
31. Hensen TB, Vahl N, Jørgensen JOL, Christiansen JS, Hagen C. Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomized, placebo-controlled study. Clin Endocrinol 1995;43:689-96
32. Johannsson G, Bosaeus I, Rosén T, Lindstedt G, Bengtsson B-Å. Normalized body composition and increased bone mineral density in adults with growth hormone deficiency after 2 years of growth hormone treatment. Endocrinol Metab 1995;2 Suppl B:152
33. Schoenle EJ, Zape J, Prader A, Torresani T, Werder EA, Zachmann M. Replacement of growth hormone (GH) in normally growing GH-deficient patients operated for craniopharyngioma. J Clin Endocrinol Metab 1995;80:374-8
34. Cuneo RC, Salomon F, Mark Wiles C, Hesp R, Sönksen PH. Growth hormone treatment in growth hormone-deficient adults. II. Effects of muscle mass and strength. J Appl Physiol 1991;70:688-94
35. Nass R, Huber RM, Klauss V, Müller OA, Schopohl J. Strasburger CJ. Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood. J Clin Endocrinol Metab 1995;80:552-7
36. Fryburg DA, Gelfand RA, Barrett EJ. Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol 1991;260:499-504
37. Russell-Jones DL, Weissberger AJ, Bowes SB, Kelly JM, Thomason M, Umpleby AM, et al. Protein metabolism in growth hormone deficiency, and effects of growth hormone replacement therapy. Acta Endocrinol (Copenh) 1993;128:44-7
38. Cuneo RC, Salomon F, Mark Wiles C, Hesp R, Sönksen PH. Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol 1991;70:695-700
39. Landin Wilhelmsen K, Wilhelmsen L, Lappas G, Rosen T, Lindestedt G, Lundberg PA, et al. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol 1994;41:351-7
40. Salomon F, Cuneo RC, Umpleby AM, Sönksen PH. Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency. Clin Sci 1994;87:201-6
41. Holmes SJ, Shalet SM. Factors influencing the desire for long-term growth hormone replacement in adults. Clin Endocrinol 1995;43:151-7
42. Valcavi R, Gaddi O, Zini M, Iavicoli M, Mellino U, Portioli I. Cardiac performance and mass in adults with hypopituitarism: effects of one year of growth hormone treatment. J Clin Endocrinol Metab 1995;80:659-66
43. Russell-Jones DL, Watts GF, Weissberger A, Naoumova R, Thompson GR, Sönksen PH. The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult growth hormone deficient patients. Clin Endocrinol 1994;41:345-50
44. Al-Shoumer KAS, Hughes C, Richmond W, Beshyah S, Johnston DG. Beneficial changes in plasma lipids. lipoproteins and apolipoproteins in hypopituitary adults after 4 years of growth hormone replacement therapy. J Endocrinol Suppl 1995;147:047
45. O'Halloran DJ, Tsatsoullis A, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM. Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab 1993;76:1344-8
46. McGauley GA, Cuneo RC, Salomon F, Sönksen PH. Psycho-social well-being before and after growth hormone treatment in adults with growth hormone deficiency. Horm Res 1990;33 Suppl 4:52-4
47. Burman P, Broman JE, Hetta J, Wiklund I, Erfurth EM, Hagg E. Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. J Clin Endocrinol Metab 1995;80: 3585-90
48. Burman P, Hetta J, Wide L, Månsson J-E, Ekman R, Karisson FA. Growth hormone treatment affects brain neurotransmitters. Clin Endocrinol 1996;44:319-24