The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 3, 1998, Pages 1157-1162

  Smith, Gregg D ^a   Smith, Maree T ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL STIMULANT AGENT; MORPHINE; MORPHINE 3 GLUCURONIDE; NORMORPHINE 3 GLUCURONIDE; UNCLASSIFIED DRUG;

ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONVULSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG METABOLISM; DRUG POTENCY; DRUG TOLERANCE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; INJECTIONS, INTRAVENTRICULAR; MALE; MORPHINE; MORPHINE DERIVATIVES; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031862949     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Anton B, Fein J, To T, Li X, Silberstein L and Evans CJ (1996) Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J Comp Neurol 368:229-251.
2. Barjavel MJ, Scherrman J-M and Bhargava HN (1995) Relationship between morphine analgesia and cortical extracellular fluid levels of morphine and its metabolites in the rat: a microdialysis study. Br J Pharmacol 116:3205-3210.
3. A receptor complex. Life Sci 54:687-694.
4. Bartlett SE, Dodd PR and Smith MT (1994b) Pharmacology of morphine and morphine-3-glucuronide at opioid, excitatory amino acid, GABA and glycine binding sites. Pharmacol Toxicol 75:73-81.
5. 14C]-gamma-aminobutyric acid from rat brain synaptosomes. Life Sci 58:447-454.
6. Brady LS and Holtzmann SG (1982) Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats. J Pharmacol Exp Ther 222:190-197.
7. D'Amour FE and Smith DL (1941) A method for determination of loss of pain sensation. J Pharmacol Exp Ther 72:74-79.
8. Evans AM and Shanahan K (1995) The disposition of morphine and its metabolites in the in situ rat isolated perfused liver. J Pharm Pharmacol 47:333-339.
9. Faura CC, Olaso MJ, Garcia Cabanes C and Horga JF (1996) Lack of morphine-6-glucuronide antinociception after morphine treatment: Is morphine-3-glucuronide involved? Pain 65:25-30.
10. Gelgor LE, Phillips S and Mitchell D (1986) Hyperalgesia following ischaemia of the rat's tail. Pain 24:251-257.
11. Gong QL, Hedner T, Hedner J, Bjorkman R and Nordberg G (1991) Antinociceptive and ventilatory effects of the morphine metabolites: Morphine-6-glucuronide and morphine-3-glucuronide. Eur J Pharmacol 193:47-56.
12. Gong QL, Hedner J, Bjorkman R and Hedner T (1992) Morphine-3-glucuronide may functionally antagonise morphine-6-glucuronide induced antinociception and ventilatory depression in the rat. Pain 48:249-255.
13. Labella FS, Pinsky C and Havlicek V (1979) Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity. Brain Res 174:263-271.
14. Löser SV, Meyer J, Freudenthaler S, Sattler M, Desel C, Meineke I and Gundert Remy U (1996) Morphine-6-O-beta-D-glucuronide but not morphine-3-O-beta-D-glucuronide binds to mu-, delta- and kappa-specific opioid binding sites in cerebral membranes. Naunyn Schmiedebergs Arch Pharmacol 354:192-197.
15. Milne RW, Nation RL and Somogyi AA (1996) The disposition of morphine and its 3-and 6-glucuronide metabolites in humans and animals, the importance of the metabolites to the pharmacological effects of morphine. Drug Metab Rev 28:345-372.
16. Nothacker HP, Reinscheid RK, Mansour A, Henningsen RA, Ardati A, Monsma FJ Jr, Watson SJ and Civelli O (1996) Primary structure and tissue distribution of the orphanin FQ precursor. Proc Nato Acad Sci USA 93:8677-8682.
17. Oguri K, Kuo CK and Yoshimura H (1989) Synthesis and analgesic effect of normorphine-3- and -6-glucuronides. Chem Pharm Bull 37:955-957.
18. Paxinos G and Watson C (1986) The Rat Brain in Stereotaxic Coordinates. San Diego, Academic Press.
19. Rothman RB (1992) A review of the role of antiopioid peptides in morphine tolerance and dependence. Synapse 12:129-138.
20. Smith GD and Smith MT (1995) Morphine-3-glucuronide: Evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat. Pain 62:51-60.
21. Smith GD, Prankerd RJ and Smith MT (1997) The biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Life Sci 61:95-104.
22. Smith MT, Watt JA and Cramond T (1990) Morphine-3-glucuronide: A potent antagonist of morphine analgesia. Life Sci 47:579-585.
23. Yeh SY, Gorodetzky CW and Krebs HA (1977) Isolation and identification of morphine 3- and 6-glucuronide, morphine 3,6-diglucuronide, morphine-3-ethereal sulfate, normorphine and normorphine-6-glucuronide as morphine metabolites in humans. J Pharm Sci 66:1288-1293.
24. Yoshimura H, Ida S, Oguri K and Tsukamoto H (1973) Biochemical basis for the analgesic activity of morphine-6-glucuronide. Biochem Pharmacol 22:1423-1430