Toxicological evaluation of dietary conjugated linoleic acid in male Fischer 344 rats

Food and Chemical Toxicology

Volumn 36, Issue 5, 1998, Pages 391-395

  Scimeca, J A ^a  

^a Kraft Foods Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; LINOLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FAT INTAKE; FOOD ANALYSIS; FOOD SAFETY; MALE; NONHUMAN; RAT; TOXICITY TESTING;

ADRENAL GLANDS; ANIMALS; BLOOD CELL COUNT; BODY WEIGHT; CHROMATOGRAPHY, GAS; DIETARY FATS, UNSATURATED; EATING; FOOD, FORMULATED; LINOLEIC ACID; MALE; ORGAN SIZE; RATS; RATS, INBRED F344; THYMUS GLAND;

EID: 0031861156     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(97)00169-5     Document Type: Article

References (19)

1. Allison D. B., Egan S. K., Barraj L. M. Caughman C. and Heimbach J. T. (1998) Estimated intakes of trans fatty acids and other fatty acids by the United States population. Journal of the American Dietetic Association. In press.
2. Chin S. F., Liu W., Storkson J. M., Pariza M. W. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. Journal of Food Composition and Analysis. 5:1992;185-197.
3. Ha Y. L., Grimm N. K., Pariza M. W. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis. 8:1987;1881-1887.
4. Ha Y. L., Grimm N. K., Pariza M. W. Newly recognized anticarcinogenic fatty acids: Identification and quantification in natural and processed cheese. Journal of Agricultural and Food Chemistry. 37:1989;75-81.
5. Ha Y. L., Storkson J., Pariza M. W. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Research. 50:1990;1097-1101.
6. Ip C., Briggs S. P., Haegele A. D., Thompson H. J., Storkson J., Scimeca J. A. The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. Carcinogenesis. 17:1996;1045-1050.
7. Ip C., Chin S. F., Scimeca J. A., Pariza M. W. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Research. 51:1991;6118-6124.
8. Ip C., Scimeca J. A. Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. Nutrition and Cancer. 27:1997;131-135.
9. Ip C., Scimeca J. A., Thompson H. Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutrition and Cancer. 24:1995;241-247.
10. Ip C., Singh M., Thompson H. J., Scimeca J. A. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Research. 54:1994;1212-1215.
11. Liew C., Schut H. A. J., Chin S. F., Pariza M. W., Dashwood R. H. Protection of conjugated linoleic acid against 2-amino-3-methylimidaza[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis. 16:1995;3037-3043.
12. Pariza M. W., Hargraves W. A. A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumours by 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 6:1985;591-593.
13. Pariza M. W., Ashoor S. H., Chu F. S., Lund D. B. Effects of temperature and time on mutagen formation in pan-fried hamburger. Cancer Letters. 7:1979;63-69.
14. Pariza M. W., Ha Y. L., Storkson J., Albright K., Lin T., Benjamin H. Effect of conjugated dienoic derivatives of linoleic acid on activation of IQ, 2-amino-3-methylimidazo[4,5-f]quinoline for mutagenesis. Proceedings of the American Association for Cancer Research. 32:1991;128.
15. Pariza M. W., Loretz L. J., Storkson J. M., Holland N. C. Mutagens and modulator of mutagenesis in fried ground beef. Cancer Research (Suppl.). 43:1983;2444s-2446s.
16. Scimeca J. A., Thompson H. J. and Ip C. (1994) Effect of conjugated linoleic acid on carcinogenesis. In Diet and Cancer. Edited under the auspices of the American Institute for Cancer Research pp. 59-593. Plenum Press, New York.
17. Shantha N. C., Crum A. D., Decker E. A. Evaluation of conjugated linoleic acid concentrations in cooked beef. Journal of Agricultural and Food Chemistry. 42:1994;1757-1760.
18. Shantha N. C., Ram L. N., O'Leary J., Hicks C. L., Decker E. A. Conjugated linoleic acid concentrations in dairy products as affected by processing and storage. Journal of Food Science. 60:1995;695-697, 720.
19. Zu H-X., Schut H. A. J. Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid. Food and Chemical Toxicology. 30:1992;9-16.