The effects of spaceflight on mRNA levels for cytokines in proximal tibia of ovariectomized rats

Aviation Space and Environmental Medicine

Volumn 69, Issue 7, 1998, Pages 626-629

  Zhang, Minzhi ^a   Turner, Russell T ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYMPHOTOXIN; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CANCELLOUS BONE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HORMONE DEFICIENCY; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; PROTEIN EXPRESSION; RAT; SPACE FLIGHT; TIBIA; TISSUE SPECIFICITY; WEIGHTLESSNESS;

NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER;

FLIGHT EXPERIMENT; MANNED; SHORT DURATION; STS-62 SHUTTLE PROJECT;

ANIMALS; BONE RESORPTION; CYTOKINES; FEMALE; GONADAL STEROID HORMONES; OVARIECTOMY; RATS; RATS, INBRED F344; RNA, MESSENGER; SPACE FLIGHT; TIBIA;

ANIMALIA;

EID: 0031858362     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Cann CE, Adachi RR. Bone resorption and mineral excretion in rats during spaceflight. Am J Physiol 1983; 244:R327-R331.
2. Cavolina JM, Evans GL, Harris SA, et al. The effects of orbital spaceflight on bone histomorphometry and messenger ribonucleic acid levels for bone matrix proteins and skeletal signaling peptides in ovariectomized growing rats. Endocrinology 1997; 138:1567-76.
3. Ghazali A, Fuentes V, Desaint C, et al. Low bone mineral density and peripheral blood monocyte activation profile in calcium stone formers with idiopathic hypercalciuria. J Clin Endo Metab 1997; 82:32-8.
4. Jilka RL, Hangoc G, Girasole G, et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992; 257:88-91.
5. Kania DM, Binkley N, Checovich M, et al. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriatrics Soc 1995; 43:236-9.
6. Kumei Y, Shimokawa H, Katano H, et al. Microgravity induces prostaglandin E2 and interleukin-6 production in normal rat osteoblasts: role in bone demineralization. J Biotech 1996; 47:313-24.
7. Lesnyak A, Sonnenfeld G, Avery L, et al. Effect of SLS-2 spaceflight on immunologic parameters of rats. J Appl Physiol 1996; 81:178-82.
8. Mann GN, Jacobs TW, Buchinsky FJ, et al. Interferon-gamma causes loss of bone volume in vivo and fails to ameliorate cyclosporin A-induced osteopenia. Endocrinology 1994; 135:1077-83.
9. Morey ER, Baylink DJ. Inhibition of bone formation during spaceflight. Science 1978; 201:1138-41.
10. Pacifici R, Rifas L, McCracken R, et al. Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proc Natl Acad Sci USA 1989; 86:2398-402.
11. Poli V, Balena R, Fattori E, et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 1994; 13:1189-96.
12. Rifas L, Kenney JS, Marcelli M, et al. Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-alpha is not regulated by ovarian steroids. Endocrinology 1995; 136:4056-67.
13. Turner RT, Evans GL, Wakley GK. Spaceflight results in depressed cancellous bone formation in rat humeri. Aviat Space Environ Med 1995; 66:771-4.
14. Turner RT, Riggs BL, Spelsberg TC. Skeletal effects of estrogen. Endocr Rev 1994; 15:275-300.
15. Westerlind KC, Morey-Holton E, Turner RT. The skeletal response to reloading following weightlessness: time and tissue dependent changes in TGF-β expression. [Abstract] American Society for Gravitational and Space Biology, San Francisco, CA: 1994.
16. Westerlind KC, Turner RT. The skeletal effects of spaceflight in growing rats: tissue-specific alterations in mRNA levels for TGF-β. J Bone Miner Res 1996; 10:843-8.
17. Westerlind KC, Turner RT. The skeletal effects of spaceflight in growing rats: reduced steady-state mRNA levels of TGF-β. J Bone Miner Res 1995; 10:843-8.
18. Wiebe SH, Hafezi M, Sandhu HS, et al. Osteoclast activation in inflammatory peridontal diseases. Oral Diseases 1996; 2:167-80.
19. Wronski TJ, Lowry PL, Walsh CC, Ignaszewski LA. Skeletal alterations in ovariectomized rats. Calcif Tissue Int 1985; 37:324-8.