Detection of enteroviral RNA in endomyocardial biopsies of patients with inflammatory cardiomyopathy and idiopathic dilated cardiomyopathy;Nachweis enteroviraler RNA in endomyokardialen biopsien bei inflammatorischer kardiomyopathie und idiopathischer dilatativer kardiomyopathie

Zeitschrift fur Kardiologie

Volumn 87, Issue 6, 1998, Pages 443-452

  Pauschinger, M ^a   Kuhl U ^a   Dorner A ^a   Schieferecke, K ^a   Petschauer, S ^a   Rauch, U ^a   Schwimmbeck, P L ^a   Kandolf, R ^b   Schultheiss, H P ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Enterovirus; Idiopathic dilated cardiomyopathy; Inflammation; Inflammatory cardiomyopathy; Polymerase chain reaction

Indexed keywords

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CELL INFILTRATION; CONGESTIVE CARDIOMYOPATHY; ENTEROVIRUS; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE BIOPSY; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MYOCARDITIS; POLYMERASE CHAIN REACTION; VIRUS DETECTION;

ADULT; AGED; ANTIGENS, CD3; BIOPSY; CARDIOMYOPATHY, DILATED; ENDOCARDIUM; ENTEROVIRUS; ENTEROVIRUS INFECTIONS; FEMALE; HLA ANTIGENS; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MYOCARDITIS; MYOCARDIUM; POLYMERASE CHAIN REACTION; RNA, VIRAL; T-LYMPHOCYTES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0031856768     PISSN: 03005860     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003920050199     Document Type: Article

References (45)

1. Abelmann WH (1973) Viral myocarditis and its sequelae. Annu Rev Med 24: 145-152
2. Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JF, Olsen EGJ, Schoen FJ (1987) Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1:3-14
3. Auffray C, Rougeon F (1980) Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 107:303-314
4. Badorff C, Noutsias M, Kühl U, Schultheiss H-P (1997) Cell-mediated cytotoxicity in hearts with dilated cardiomyopathy: correlation with interstitial fibrosis and foci of activated T lymphocytes. J Am Coll Cardiol 29:429-434
5. Bender JR (1991) Idiopathic dilated cardiomyopathy. An immunologic, genetic or infectious disease, or all of the above? Circulation 83:704-706
6. Bowles NE, Richardson PJ, Olson EGJ, Archard LC (1986) Detection of coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 17:1120-1123
7. Dodge HT, Sheehan FH (1983) Quantitative contrast angiography for assessment of ventricular performance in heart disease. J Am Coll Cardiol 1:73-81
8. Fallon JT (1987) Myocarditis and dilated cardiomyopathy: different stages of the same disease? In: Waller B (ed) Contemporary Issues in cardiovascular clinics 18: 155-162
9. Figulla HR, Stille-Siegener M, Mall G, Heim A, Kreuzer H (1995) Myocardial enterovirus infection with left ventricular dysfunction: a benign disease compared with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 25:1170-1175
10. Foulis AK, Farquharson MA, Cameron SO, McGill M, Schonke H, Kandolf R (1990) A search for the presence of the enteroviral capsid protein VP1 in pancreases of patients with type I (insulin-dependent) diabetes and pancreases and hearts of infants who died of coxsackieviral myocarditis. Diabetologia 33:290-298
11. Grasso M, Arbustini E, Silini E, Diegoli M, Percivalle E, Ratti G, Bramerio M, Gavazzi A, Vigano M, Milanesi G (1992) Search for coxsackievirus B3 RNA in idiopathic dilated cardiomyopathy using gene amplification by polymerase chain reaction. Am J Cardiol 69:658-64
12. Hohenadel C, Klingel K, Mertsching J, Hofschneider PH, Kandolf R (1991) Strand specific detection of enteroviral RNA in myocardial tissue by in situ hybridization. Moll Cell Probes 5:11-20
13. Jin O, Sole MJ, Butany JW, Chia W-K, McLaughlin PR, Liu P, Liew CC (1990) Detection of enterovirus RNA in myocardial biopsies from patients with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction. Circulation 82:8-16
14. Kandolf R, Klingel K, Mertsching H, Canu A, Hohenadel C, Zell R, Reimann BY, Heim A, McManus BM, Foulis AK, Schultheiss H-P, Erdmann E, Riecker G (1991) Molecular studies on enteroviral heart disease: patterns of acute and persistent infections. Eur Heart J 12 (Suppl D): 49-55
15. Kandolf R, Hofschneider PH (1989) Viral heart disease. Springer Semin Immunopathol 11:1-13
16. Kandolf R, Ameis D, Kirschner P, Canu A, Hofschneider PH (1987) In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease. Proc Natl Acad Sci 84:6272-6276
17. Klump WM, Bergmann I, Muller BC, Ameis D, Kandolf R (1990) Complete nucleotide sequence of infectious coxsackievirus B3 cDNA: two initial 5′ uridine residues are regained during plus-strand RNA synthesis. J Virol 64:1573-1583
18. Koide H, Kitaura Y, Deguchi H, Ukimura A, Kawamura K, Hirai K (1992) Genomic detection of enteroviruses in the myocardium. Studies on animal hearts with coxsackievirus B3 myocarditis and endomyocardial biopsies from patients with myocarditis and dilated cardiomyopath. Jpn Circ 17:97-106
19. Kühl U, Noulsias M, Seeberg B, Schultheiss H-P (1996) Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy. Heart 75:295-300
20. Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiss HP (1994) Chronic inflammation in the myocardium of patients with clinically suspected dilated cardiomyopathy. J Cardiac Failure 1:13-25
21. Lauer B, Niederau C, Kühl U, Schannwell M, Pauschinger M, Strauer B-E, Schultheiss HP (1997) Cardiac Troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol 30:1354-1359
22. Limas CJ, Goldenberg IF, Limas C (1984) Autoantibodies against adrenoreceptors in human idiopathic dilated cardiomyopathy. Eur Heart J 5:97-103
23. Linder J, Cassling RS, Rogler WC, Wilson JF, Markin RS, Sears TD, McManus BM (1985) Immunohistological characterization of lymphocytes in uninflamed ventricular myocardium. Arch Pathol Lab Med 109:917-920
24. Longson M, Cole F, Davies D (1969) Isolation of a coxsackievirus group B, type 5, from the heart of a fatal case of myocarditis in an adult. J Clin Pathol 22:654-658
25. Martin AB, Webber S, Fricker FL, Jaffe R, Demmler G, Kearny D, Zhang Y-H, Bodurtha J, Gelb B, Ni J, Bricker JT, Towbin JA (1994) Acute myocarditis, rapid diagnosis by PCR in children. Circulation 90: 330-339
26. Milei J, Bortman G, Fernandez-Alonso G, Grancelli H, Beigelman R (1990) Immunochemical staining of lymphocytes for the reliable diagnosis of myocarditis in endomyocardial biopsies. Cardiology 77:77-85
27. Mues B, Brisse B, Zwado G, Themann H, Bender F, Sorg C (1990) Phenotyping of macrophages with monoclonal antibodies of myocarditis. Eur Heart J 11:619-627
28. Nakajiama-Iijma S, Hamada H, Reddy P, Kakznaga T (1985) Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns. Proc Natl Acad Sci USA 82: 6133-6137
29. Pauschinger M, Meissner G, Preis S, Kühl U, Canu A, Kandolf R, Schultheiss H-P, Strauer BE (1994) Detection of enteroviral RNA by polymerase chain reaction (PCR) in patients with myocarditis (MC) and dilated cardiomyopathy (DCM). J Am Coll Cardiol (Abstract)2:880
30. Petitjean J, Kopecka H, Freymuth F, Langlard JM, Scanu P, Galateau F, Bouhour JB, Fernere M, Charbonneau P, Komajda M (1992) Detection of enteroviruses in endomyocardial biopsy by molecular approach. J Med Virol 37:76-82
31. Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O'Connel J, Olsen E, Thiene G, Goodwill J, Gayarfas I, Martin I, Nordet P (1996) Report of the 1995 world health organization/international society and federation of cardiology task force on the definition and classification of cardiomyopathies. Circulation 93:841-842
32. Rose NR, Herskowitz A, Neumann DA, Neu N (1988) Autoimmune myocarditis: a paradigm of post-infection autoimmune disease. Immunology Today 9:117-119
33. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA (1988) Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487-491
34. Schönian U, Crombach M, Maisch B (1993) Assessment of cytomegalovirus DNA and protein expression in patients with myocarditis. Clin Immunol Immunopathol 68:229-233
35. Schultheiss H-P, Schulze K, Schauer R, Witzenbichler B, Strauer BE (1995) Antibody-mediated imbalance of myocardial energy metabolism, a causal factor of cardiac failure. Circ Res 76:64-72
36. Schultheiss H-P (1989) The significance of autoantibodies against ADP/ATP carrier for the pathogenesis of myocarditis and dilated cardiomyopathy - clinical and experimental data. Semin Immunopath 11:15-30
37. Schultheiss H-P (1992) Cardiomyopathy: a post viral autoimmune disease? Ann Med Interne 143:387-390
38. Schulze K, Becker BF, Schultheiss H-P (1989) Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo. Circ Res 64:179-192
39. Schwimmbeck PL, Badorff C, Schultheiss H-P, Strauer BE (1994) Transfer of human MC into severe combined immunodeficiency mice. Circ Res 75:156-164
40. Steenbergen C, Kolbeck PC, Wolfe JA, Anthony RM, Sanfilippo FP, Jennings RB (1986) Detection of lymphocytes in endomyocardium using immunohistochemical techniques. Relevance to evaluation of endomyocardial biopsies in suspected cases of lymphocytic myocarditis. J Appl Cardiol 1:63-73
41. Sutton G, Harding H, Trueheart R, Clark H (1967) Coxsackie B4 myocarditis in an adult: successful isolation of virus from ventricular myocardium. Aerospace Med 38:66-69
42. Tracy S, Chapmann NM, McManus BM, Pallansch MA, Beck MA, Carstens JA (1990) Molecular and serologic evaluation of enteroviral involvement in human myocarditis. J Mol Cell Cardiol 22: 403-414
43. Why HJF, Meany BT, Richardson PJ, Olsen EGJ, Bowles NE, Cunningham L, Freeke CA, Archard LC (1994) Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy. Circulation 89:2582-2589
44. Weiss LW, Liu XF, Chang KL, Billingham ME (1992) Detection of enteroviral RNAm idiopathic dilated cardiomyopathy and other human cardiac tissue. J Clin Invest 90:156-159
45. Woodruff JF (1980) Viral myocarditis. Areview. Am J Pathol 101:425-484