Hypermethylation of HpaII recognition sequences within the 5' coding region of the estrogen receptor gene is not associated with estrogen receptor negativity in primary breast tumours

Anticancer Research

Volumn 18, Issue 3 A, 1998, Pages 1709-1712

  Kay, Peter H ^a   Hähnel, Roland ^a   Gunn, Howard ^a   Harmon, Donna ^a   Song, Jenny ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Breast carcinoma; DNA methylation; Estrogen receptor

Indexed keywords

DNA; ESTROGEN RECEPTOR; RESTRICTION ENDONUCLEASE;

ARTICLE; BREAST CARCINOMA; CLINICAL ARTICLE; DNA METHYLATION; DNA SEQUENCE; FEMALE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADENOCARCINOMA; BREAST NEOPLASMS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENOTYPE; HUMANS; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); SUBSTRATE SPECIFICITY;

EID: 0031856459     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. McGuire WL: Hormone receptors: their role in predicting prognosis and response to endocrine therapy. Semin Oncol 5: 428-433, 1978.
2. Bird AP: CpG-rich islands and the function of DNA methylation. Nature 321: 203-213, 1986.
3. Cedar H, Razin A: DNA methylation and development. Biochim Biophys Acta 1049: 1-8, 1990.
4. Ottaviano YL, Issa J-P, Parl FF, Smith HS, Baylin SB, Davidson, NE: Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res 54: 2552-2555, 1994.
5. Lapidus RG, Ferguson AT, Ottaviano YL, Parl FF, Smith HS, Weitzman SA. Baylin SB, Issa J-P J, Davidson NE: Methylation of estrogen and progesterone receptor gene 5′ CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors. Clinical Cancer Res 2: 805-810, 1996
6. Hahnel R, Avenell MHJ, Hahnel E: Estrogen and progesterone receptor assays by the EIA method (Abbott) of low speed supernates of breast cancer homogenates. Clin Chem 35: 2226-2227, 1989.
7. Maniatis I, Fritsch EF, Sambrook J: Molecular cloning. A laboratory manual. Cold Spring Harbor, New York, 1982.
8. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 95: 503-509, 1975.
9. Green S, Walter P, Kumar V, Krust A, Bornen J-M, Argos P, Chambon P: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320: 134-139, 1986.
10. Roodi N, Bailey LR, Kao W, Verrier CS, Yee CJ, Dupont WD, Parl FF: Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer. J Natl Cancer Inst 87: 446-451, 1995.
11. Clark SJ, Harrison J, Frommer M: CpNpG methylation in mammalian cells. Nature Genet 10: 20-27, 1995.
12. Ferguson AT, Lapidus RG, Baylin SB, Davidson NE: Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res 55: 2279-2283, 1995.
13. Kass DH, Shen M, Appel NB, Anderson DE, Saunders GF: Examination of DNA of chromosomal hot spots associated with breast cancer. Anticancer Res 13: 1245-1251, 1993.
14. Piva R, Rimondi AP, Hanau S, Maestri I, Alvisi A, Kumar VL, del Senno L: Different methylation of oestrogen receptor DNA in human breast carcinomas with and without oestrogen receptor. Br J Cancer 61: 270-275, 1990.
15. Petrangeli E, Lubrano C, Ravenna L, Vacca A, Cardillo MR, Salvatori L, Sciarra F, Frati L, Gulino A: Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues. Br J Cancer 72: 973-975, 1995.
16. Tang Z, Treileux I, Brown M: A transcriptional enhancer required for the differential expression of the human estrogen receptor in breast cancers. Mol Cell Biol 17: 1274-1280, 1997.