Ulcer bed infection. Report of a case of enlarging venous leg ulcer colonized by Pseudomonas aeruginosa

APMIS

Volumn 106, Issue 7, 1998, Pages 721-726

  Danielsen, Lis ^a   Balslev, Eva ^b   Döring, Gerd ^c   Høiby, Niels ^d   Madsen, Søren Munk ^e   Ågren, Magnus ^a   Thomsen, Henrik Klem ^a   Steen Fos, Henrik H ^f   Westh, Henrik ^f  

^a BISPEBJERG HOSPITAL   (Denmark)

^b ROSKILDE HOSPITAL   (Denmark)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^e FREDERIKSBERG HOSPITAL   (Denmark)

^f STATENS SERUM INSTITUT   (Denmark)

Author keywords

Cytotoxicity; Pseudomonas aeruginosa exotoxin A; Wound exudate

Indexed keywords

EXOTOXIN;

ADULT; ARTICLE; CASE REPORT; CELLULITIS; CYTOTOXICITY; EXUDATE; GRAM NEGATIVE INFECTION; HISTOLOGY; HUMAN; IMMUNOLOGY; INFECTION; LEG ULCER; MALE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0031854605     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1998.tb00218.x     Document Type: Article

References (21)

1. Danielsen, L., Westh, H., Balslev, E., Rosdahl, V. T. & Döring, G.: Pseudomonas aeruginosa exotoxin A antibodies in rapidly deteriorating chronic leg ulcers. Lancet 347: 265, 1996.
2. Danielsen, L., Cherry, G. W., Harding, K. & Rollman, O.: Cadexomer iodine on venous leg ulcers colonized by Pseudomonas aeruginosa. J. Wound Care 6: 169-172, 1997.
3. Danielsen, L., Madsen, S. M., Henriksen, L., Sindrup, J. & Petersen, L. J.: Subbandage pressure measurements comparing a long-stretch with a short-stretch compression bandage. In press. Acta Derm. Venereol. (Stockh.)
4. Döring, G., Goldstein, W., Röll, A., Schiotz, P. O., Hoiby, N. & Botzenhart, K.: Role of Pseudomonas aeruginosa exoenzymes in lung infections of patients with cystic fibrosis. Infect. Immun. 49: 557-562, 1985.
5. Döring, G. & Müller, E.: Different sensitivity of Pseudomona aeruginosa exotoxin A and diphtheria toxins to enzymes from polymorphonuclear leukocytes. Microb. Pathog. 6: 287-295, 1989.
6. Freer, J. H. & Arbuthnott, J. P.: Toxins of Staphylococcus aureus. Pharmacol. Ther. 19: 55-106, 1983.
7. Gill, D. M.: Bacterial toxins: a table of lethal amounts. Microbiol. Rev. 46: 86-94, 1982.
8. Halbert, A. R., Stacey, M. C., Rohr, J. B. & Jopp-MacKay, A.: The effect of bacterial colonization on venous ulcer healing. Australas. J. Dermatol. 33: 75-80, 1992.
9. Hansson, C., Hoborn, J., Möller, Å. & Svanbeck, G.: The microbial flora in venous leg ulcers without clinical signs of infection. Repeated culture using a validated standardised microbiological technique. Acta. Derm. Venereol. (Stockh.) 75: 24-30, 1995.
10. Heggers, J. P., Haydon, S., Ko, F., Hayward, P. G., Carp, S. & Robson, M. C.: Pseudomonas aeruginosa exotoxin A: its role in retardation of wound healing. J. Burn. Care Rehab. 13: 512-518, 1992.
11. Hoiby, N.: Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey. Acta path. microbiol. scand. (Suppl. 262): 1-96, 1977.
12. Hoiby, N. & Rosendal, K.: Epidemiology of Pseudomonas aeruginosa infection in patients treated at a cystic fibrosis centre. Acta path. microbiol. scand. Sect. B 88: 125-131, 1980.
13. Iglewski, B. H. & Kabat, D.: NAD-dependent inhibitions of protein synthesis by Pseudomonas aeruginosa toxin. Proc. Natl. Acad. Sci. USA 72: 2284-2288, 1975.
14. Kossodo, S. de, Houba, V. & Grau, G. E.: Assaying tumor necrosis factor concentrations in human serum. A WHO International Collaborative Study. J. Immunol. Methods 182: 107-114, 1995.
15. Kratz, G., Lake, M. & Gidlund, M.: Insulin like growth factor-1 and -2 and their role in the re-epithelialisation of wounds. Interactions with insulin like growth factor binding protein type 1. Scand. J. Plast. Reconstr. Hand Surg. 28: 107-112, 1994.
16. Kronborg, G., Hansen, M. B., Svenson, M., Fomsgaard, A., Hoiby, N. & Bendtzen, K.: Cytokines in sputum and serum from patients with cystic fibrosis and chronic Pseudomona aeruginosa infection as markers of destructive inflammation in the lungs. Pediatr. Pulmonol. 15: 292-297, 1993.
17. Kronborg, G., Fomsgaard, A., Jensen, E. T., Kharazmi, A. & Hoiby, N.: Induction of oxidative burst response in human neutrophils by immune complexes made in vitro of lipopolysaccharide and hyperimmune serum from chronically infected patients. APMIS 101: 887-894, 1993.
18. Lookingbill, D. P., Miller, S. H. & Knowles, R. C.: Bacteriology of chronic leg ulcers. Arch. Dermatol. 114: 1765-1768, 1978.
19. Mausen, S. M., Westh, H., Danielsen, L. & Rosdahl, K. T.: Bacterial colonization and healing of venous leg ulcers. APMIS 104: 895-899, 1996.
20. Middlebrook, J. L. & Dorland, R. B.: Bacterial toxins: cellular mechanisms of action. Microbiol. Rev. 48: 199-221, 1984.
21. Morris, R. E., Manhart, M. D. & Saelinger, C. B.: Receptor-mediated entry of Pseudomonas toxin: methylamine blocks clustering step. Infect. Immun. 48: 806-811, 1983.