메뉴 건너뛰기




Volumn 15, Issue 1, 1998, Pages 89-95

Molecular actions of droperidol on human CNS ion channels

Author keywords

Droperidol; Human brain; Lipid bilayer; Molecular mechanism; Sodium channel; Voltage clamp

Indexed keywords

ANXIOLYTIC AGENT; DROPERIDOL; ION CHANNEL; SODIUM CHANNEL;

EID: 0031852022     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2346.1998.00221.x     Document Type: Article
Times cited : (3)

References (22)
  • 1
    • 0017255979 scopus 로고
    • Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
    • Creese I, Burt DR, Snyder SH. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 1976; 192: 481-483.
    • (1976) Science , vol.192 , pp. 481-483
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 2
    • 0020041684 scopus 로고
    • Antiemetics: Neurotransmitter receptor binding predicts therapeutic action
    • Peroutka SJ, Snyder SH. Antiemetics: Neurotransmitter receptor binding predicts therapeutic action. Lancet 1982; 85: 658-659.
    • (1982) Lancet , vol.85 , pp. 658-659
    • Peroutka, S.J.1    Snyder, S.H.2
  • 3
    • 7344243685 scopus 로고
    • Receptor-drug dissociation rate of unlabeled neuroleptics: Relation to binding affinity and lipophilicity
    • Leysen JE, Gommeren W. Receptor-drug dissociation rate of unlabeled neuroleptics: relation to binding affinity and lipophilicity. Br J Pharmacol 1983; 80 (Suppl.): 534-540.
    • (1983) Br J Pharmacol , vol.80 , Issue.SUPPL. , pp. 534-540
    • Leysen, J.E.1    Gommeren, W.2
  • 4
    • 0024412775 scopus 로고
    • Profile of in vitro affinities of neuroleptics at different rat brain receptors: Cluster analysis comparison with pharmacological and clinical profiles
    • Testa R, Abiatti G, Ceserani R. Profile of in vitro affinities of neuroleptics at different rat brain receptors: cluster analysis comparison with pharmacological and clinical profiles. Pharmacol Res 1989; 6: 571-576.
    • (1989) Pharmacol Res , vol.6 , pp. 571-576
    • Testa, R.1    Abiatti, G.2    Ceserani, R.3
  • 5
    • 7344235312 scopus 로고
    • The local anaesthetic effect of droperidol on single ion channels of peripheral nerves
    • Bräu M, Cronenberg R, Vogel W, Hempelmann G. The local anaesthetic effect of droperidol on single ion channels of peripheral nerves. Anaesthesist 1994; 43: 793.
    • (1994) Anaesthesist , vol.43 , pp. 793
    • Bräu, M.1    Cronenberg, R.2    Vogel, W.3    Hempelmann, G.4
  • 6
    • 0022576638 scopus 로고
    • The pharmacokinetics of droperidol in anesthetized patients
    • Fischler M, Bonnet F, Trang H et al. The pharmacokinetics of droperidol in anesthetized patients. Anesthesiology 1986; 64: 486-489.
    • (1986) Anesthesiology , vol.64 , pp. 486-489
    • Fischler, M.1    Bonnet, F.2    Trang, H.3
  • 7
    • 0023802710 scopus 로고
    • Pharmacokinetics of droperidol in surgical patients under different conditions of anaesthesia
    • Lehman KA, Van Peer A, Ikonomakis M, Gasparini R, Heykants J. Pharmacokinetics of droperidol in surgical patients under different conditions of anaesthesia. Br J Anaesth 1988; 61: 297-301.
    • (1988) Br J Anaesth , vol.61 , pp. 297-301
    • Lehman, K.A.1    Van Peer, A.2    Ikonomakis, M.3    Gasparini, R.4    Heykants, J.5
  • 8
    • 0024280869 scopus 로고
    • Structure and function of voltage-sensitive ion channels
    • Catterall WA. Structure and function of voltage-sensitive ion channels. Science 1988; 242: 50-61.
    • (1988) Science , vol.242 , pp. 50-61
    • Catterall, W.A.1
  • 9
    • 0025237098 scopus 로고
    • Molecular actions of pentobarbital isomers on sodium channels from human brain cortex
    • Frenkel C, Duch DS, Urban BW. Molecular actions of pentobarbital isomers on sodium channels from human brain cortex. Anesthesiology 1990; 72: 640-649.
    • (1990) Anesthesiology , vol.72 , pp. 640-649
    • Frenkel, C.1    Duch, D.S.2    Urban, B.W.3
  • 10
    • 0025784658 scopus 로고
    • Human brain sodium channels as one of the molecular target sites for the new intravenous anaesthetic propofol (2,6-diisopropylphenol)
    • Frenkel C, Urban BW. Human brain sodium channels as one of the molecular target sites for the new intravenous anaesthetic propofol (2,6-diisopropylphenol). Eur J Pharmacol 1991; 208: 75-79.
    • (1991) Eur J Pharmacol , vol.208 , pp. 75-79
    • Frenkel, C.1    Urban, B.W.2
  • 11
    • 0027318120 scopus 로고
    • Effects of i.v. anaesthetics on human brain sodium channels
    • Frenkel C, Duch DS, Urban BW. Effects of i.v. anaesthetics on human brain sodium channels. Br J Anaesth 1993; 71: 15-24.
    • (1993) Br J Anaesth , vol.71 , pp. 15-24
    • Frenkel, C.1    Duch, D.S.2    Urban, B.W.3
  • 12
    • 7344264538 scopus 로고
    • Molecular interactions of droperidol with single human CNS sodium channels
    • Frenkel C, Radke PW, Urban BW. Molecular interactions of droperidol with single human CNS sodium channels (Abstr.). Eur J Anaesthsiol 1994; 12: 213.
    • (1994) Eur J Anaesthsiol , vol.12 , pp. 213
    • Frenkel, C.1    Radke, P.W.2    Urban, B.W.3
  • 14
    • 0025807053 scopus 로고
    • Molecular models of anesthetic action on sodium channels, including those from human brain
    • Urban BW, Frenkel C, Duch DS, Kauff AB. Molecular models of anesthetic action on sodium channels, including those from human brain. Ann NY Acad Sci 1991; 625: 327-345.
    • (1991) Ann NY Acad Sci , vol.625 , pp. 327-345
    • Urban, B.W.1    Frenkel, C.2    Duch, D.S.3    Kauff, A.B.4
  • 15
    • 0017396421 scopus 로고
    • The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition
    • Cohen RS, Blomberg F, Berzins K, Siekevitz P. The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition. J Cell Biol 1977; 74: 181-203.
    • (1977) J Cell Biol , vol.74 , pp. 181-203
    • Cohen, R.S.1    Blomberg, F.2    Berzins, K.3    Siekevitz, P.4
  • 16
    • 0023754883 scopus 로고
    • Batrachotoxin. A window on the allosteric nature of the voltage-sensitive sodium channel
    • Brown GB. Batrachotoxin. A window on the allosteric nature of the voltage-sensitive sodium channel. Int Rev Neurobiol 1988; 29: 77-116.
    • (1988) Int Rev Neurobiol , vol.29 , pp. 77-116
    • Brown, G.B.1
  • 18
    • 0003601534 scopus 로고
    • Merck Co. Inc., Rahway, NY, USA.
    • Merck Index. Merck Co. Inc., Rahway, NY, USA. 1989.
    • (1989) Merck Index
  • 20
    • 0030894878 scopus 로고    scopus 로고
    • Interactions of ethanol with single human brain sodium channels
    • Frenkel C, Wartenberg HC, Rehberg BW. Interactions of ethanol with single human brain sodium channels. Neurosci Res Commun 1997; 20: 113-120.
    • (1997) Neurosci Res Commun , vol.20 , pp. 113-120
    • Frenkel, C.1    Wartenberg, H.C.2    Rehberg, B.W.3
  • 21
    • 0029991260 scopus 로고    scopus 로고
    • Central nervous system sodium channels are significantly suppressed at clinical concentrations of volatile anesthetics
    • Rehberg B, Xiao YH, Duch DS. Central nervous system sodium channels are significantly suppressed at clinical concentrations of volatile anesthetics. Anesthesiology 1996; 84: 1223-1233.
    • (1996) Anesthesiology , vol.84 , pp. 1223-1233
    • Rehberg, B.1    Xiao, Y.H.2    Duch, D.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.