Differential activities of E2f family members: Unique functions in regulating transcription

Molecular Carcinogenesis

Volumn 22, Issue 3, 1998, Pages 190-198

  Pierce, Angela M ^a   Schneider Broussard, Robin ^a   Philhower, Jennifer L ^a   Johnson, David G ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Cell cycle; P130; Retinoblastoma tumor suppressor

Indexed keywords

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RETINOBLASTOMA; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; E2F4 TRANSCRIPTION FACTOR; E2F5 TRANSCRIPTION FACTOR; HUMANS; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEINS; RECOMBINANT FUSION PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0031850645     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P     Document Type: Article

References (46)

1. Johnson DG, Cress WD, Jakoi L, Nevins JR. Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci USA 91:12823-12827, 1994.
2. Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev 8:2680-2690, 1994.
3. Ginsberg D, Vairo G, Chittenden T, et al. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev 8:2665-2679, 1994.
4. Pierce A, Fischer S, Conti C, Johnson D. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene, 16:1267-1276
5. Slansky JE, Farnham PJ. Introduction to the E2F family: Protein structure and gene regulation. Curr Top Microbiol Immunol 208:1-30, 1996.
6. Hsiao K-M, McMahon SL, Farnham PJ. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev 8:1526-1537, 1994.
7. Johnson DG, Ohtani K, Nevins JR. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev 8:1514-1525, 1994.
8. Lam EW, Watson RJ. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J 12:2705-2713, 1993.
9. Hamel PA, Gill RM, Phillips RA, Gallie BL. Transcriptional repression of the E2-containing prompters EllaE, c-myc, and RB1 by the product of the RB1 gene. Mol Cell Biol 12:3431-3438, 1992.
10. Hiebert SW, Blake M, Azizkhan J, Nevins JR. Role of E2F transcription factor in E1A-mediated trans activation of cellular genes. J Virol 65:3547-3552, 1991.
11. Hiebert SW, Lipp M, Nevins JR. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc Natl Acad Sci USA 86:3594-3598, 1989.
12. Schulze A, Zerfass K, Spitkovsky D, et al. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci USA 92:11264-11268, 1995.
13. Ohtani K, DeGregori J, Nevins JR. Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci USA 92:12146-12150, 1995.
14. Tommasi S, Pfeifer GP. In vivo structure of the human cdc2 promoter: Release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol Cell Biol 15:6901-6913, 1995.
15. 1 events and regulation of cell proliferation. Science 246:603-608, 1989.
16. Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA. Cell cycle specific association of E2F with the p130 E1A-binding protein. Genes Dev 7:2392-2404, 1993.
17. Johnson DG. Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene 11:1685-1692, 1995.
18. Scharwz JK, Devoto SH, Smith EJ, Chellappan SP, Jakoi L, Nevins JR. Interactions of the p107 and Rb proteins, with E2F during the cell proliferation response. EMBO J 12:1013-1020, 1993.
19. Adnane J, Shao Z, Robbins PD. The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter. J Biol Chem 270:8837-8843, 1995.
20. Bremner R, Cohen BL, Sopta M, et al. Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol 15:3256-3265, 1995.
21. Weintraub SJ, Chow KNB, Luo RX, Zhang SH, He S, Dean DC. Mechanism of active-transcriptional repression by the retinoblastoma protein. Nature 375:812-815, 1995.
22. Sellers WR, Rodgers JW, Kaelin Jr. WG. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci USA 92:11544-11548, 1995.
23. Starostik P, Chow KNB, Dean DC. Transcriptional repression and growth suppression by the p107 pocket protein. Mol Cell Biol 16:3606-3614, 1996.
24. Moberg K, Starz MA, Lees JA. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol 16:1436-1449, 1996.
25. Ikeda M-A, Jakoi L, Nevins JR. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci USA 93:3215-3220, 1996.
26. Hijmans EM, Voorhoeve PM, Beijersbergen RL, van'T Veer LJ, Bernards R. E2F-5 a new E2F family-member that interacts with p130 in vivo. Mol Cell Biol 15:3082-3089, 1995.
27. Kaelin WG, Krek W, Sellers WR, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351-364, 1992.
28. Sardet C, Vidal M, Cobrink D, et al. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci USA 92:2403-2407, 1995
29. Krek W, Ewen ME, Shirodkar S, Arany A, Kaelin WG, Livingston DM. Negative regulation of the growth-promoting transcription factor E2F-1 by stably bound cyclin A-dependent protein kinase. Cell 78:161-172, 1994.
30. Xu M, Sheppard K-A, Peng C-Y, Yee AS, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol 14:8420-8431, 1994.
31. Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. Specific regulation of E2F family members by cyclin-dependent kinases. Mol Cell Biol 17:3867-3875, 1997.
32. Müller H, Moroni MC, Vigo E, Petersen BO, Bartek J, Helin K. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol 17:5508-5520, 1997.
33. Lin S-Y Black AR, Kostic D, Pajovic S, Hoover CN, Azizkhan JC. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol 16:1668-1675, 1996.
34. Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol 16:1659-1667, 1996.
35. Souza RF, Yin J, Smolinski KN, et al. Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors. Cancer Res 57:2350-2353, 1997.
36. Helin K, Wu C-L, Fattaey AR. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev 7:1850-1861, 1993.
37. Johnson DG, Schwarz JK, Cress WD, Nevins JR. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349-352, 1993.
38. Sadowski I, Ptashne M. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res 17:7539, 1989.
39. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. Distinct roles for E2F proteins in cell growth control apoptosis. Proc Natl Acad Sci USA 94:7245-7250, 1997.
40. Herr W. Oct-1 and Oct-2: Differential transcriptional regulation by proteins that bind to the same DNA sequence. In: McKnight S, Yamamoto K (eds). Transcriptional Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1992, pp. 1103-1135.
41. Lee KAW, Masson N. Transcriptional regulation by CREB and its relatives. Biochem Biophys Acta 1174:221-233, 1993.
42. Magae J, Wu C-L, Illenye S, Harlow E, Heintz NH. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci 109:1717-1726, 1996.
43. Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D. The subcellular localization of E2F-4 is cell-cycle dependent. Proc Natl Acad Sci USA 94:5095-5100, 1997.
44. Tao Y, Kassatly RF, Cress WD, Horowitz JM. Subunit composition determines E2F DNA-binding site specifically. Mol. Cell Biol 17:6994-7007, 1997.
45. Shin EK, Shin A, Paulding C, Schaffhausen B, Yee AS. Multiple changes in E2F function and regulation occur upon muscle differentiation. Mol Cell Biol 15:2252-2262, 1995.
46. INK4A-mediated growth suppression. Mol Cell Biol 16:1047-1057, 1996.