The herpes simplex virus type 1 UL8 protein influences the intracellular localization of the UL52 but not the ICP8 or POL replication proteins in virus-infected cells

Journal of General Virology

Volumn 77, Issue 9, 1996, Pages 2241-2249

  Marsden, H S ^a   Cross, A M ^a   Francis, G J ^a,b   Patel, A H ^a   MacEachran, K ^a   Murphy, M ^a   McVey, G ^a   Haydon, D ^a   Abbotts, A ^a   Stow, N D ^a  

^a INSTITUTE OF VIROLOGY   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MUTANT PROTEIN; POL PROTEIN; POLYCLONAL ANTIBODY; VIRUS PROTEIN;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPLICATION; HERPES; HERPES SIMPLEX VIRUS 1; IMMUNOASSAY; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; STOP CODON; VIRUS MUTANT; VIRUS REPLICATION;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1; ORYCTOLAGUS CUNICULUS;

EID: 10144219958     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-9-2241     Document Type: Article

References (36)

1. L16 are dispensable for the replication of herpes simplex virus type 1 in cell culture. Journal of Virology 65, 938-944.
2. Brown, S. M., Ritchie, D. A. & Subak-Sharpe, J. H. (1973). Genetic studies with herpes simplex virus type I. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map. Journal of General Virology 18, 329-346.
3. Calder, J. M. & Stow, N. D. (1990). Herpes simplex virus helicase-primase: the UL8 protein is not required for DNA-dependent ATPase and DNA helicase activities. Nucleic Acids Research 18, 3573-3578.
4. Calder, J. M., Stow, E. C. & Stow, N. D. (1992). On the cellular localization of the components of the herpes simplex virus type I helicase-primase complex and the viral origin-binding protein. Journal of General Virology 73, 531-538.
5. Challberg, M. D. (1991). Herpes simplex virus DNA replication. Seminars in Virology 2, 247-256.
6. Crute, J. J., Tsurumi, T., Zhu, L., Weller, S. K., Olivo, P. D., Challberg, M. D., Mocarski, E. S. & Lehman, I. R. (1989). Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products. Proceedings of the National Academy of Sciences, USA 86, 2186-2189.
7. Crute, J. J., Bruckner, R. C., Dodson, M. S. & Lehman, I. R. (1991). Herpes simplex 1 helicase-primase. Identification of two nucleocapsid triphosphatase sites that promote DNA helicase action. Journal of Biological Chemistry 266, 21252-21256.
8. Dargan, D. J., Patel, A. H. & Subak-Sharpe, J. H. (1995). Herpes simplex virus type 1-specific particles produced by infected cells when viral DNA replication is blocked. Journal of Virology 69, 4924-4932.
9. Dodson, M. S. & Lehman, I. R. (1991). Association of DNA helicase and primase activities with a subassembly of the herpes simplex virus 1 helicase-primase composed of the UL5 and UL52 gene products. Proceedings of the National Academy of Sciences, USA 88, 1105-1109.
10. Dodson, M. S., Crute, J. J., Bruckner, R. C. & Lehman, I. R. (1989). Overexpression and assembly of the herpes simplex virus type 1 helicase-primase in insect cells. Journal of Biological Chemistry 264, 20835-20838.
11. Dracheva, S., Koonin, E. V. & Crute, J. J. (1995). Identification of the primase active site of the herpes simplex virus type 1 helicase-primase. Journal of Biological Chemistry 270, 14148-14153.
12. Gorbalenya, A. E., Koonin, E. V., Donchenko, A. P. & Blinov, V. M. (1989). Two related families of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Research 17, 4713-4730.
13. Gottlieb, J., Marcy, A. I., Coen, D. M. & Challberg, M. D. (1990). The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. Journal of Virology 64, 5976-5987.
14. Klinedinst, D. K. & Challberg, M. D. (1994). Helicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity. Journal of Virology 68, 3693-3701.
15. Liptak, L. M., Uprichard, S. L. & Knipe, D. M. (1996). Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures. Journal of Virology 70, 1759-1767.
16. Lukonis, C. J. & Weller, S. K. (1996). Characterization of nuclear structures in cells infected with herpes simplex virus type 1 in the absence of viral DNA replication. Journal of Virology 70, 1751-1758.
17. Marsden, H. S., Murphy, M., McVey, G. L., MacEachran, K. A., Owsianka, A. M. & Stow, N. D. (1994). Role of the carboxy terminus of herpes simplex virus type 1 DNA polymerase in its interaction with UL42. Journal of General Virology 75, 3127-3135.
18. MacLean, C. A., Efstathiou, S., Elliott, M. L., Jamieson, F. E. & McGeoch, D. J. (1991). Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins. Journal of General Virology 72, 897-906.
19. McLean, G. W., Abbotts, A. P., Parry, M. E., Marsden, H. S. & Stow, N. D. (1994). The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein. Journal of General Virology 75, 2699-2706.
20. Patel, A. H., Rixon, F. J. Cunningham, C. & Davison, A. J. (1996a). Isolation and characterization of herpes simplex virus mutants defective in the UL6 gene. Virology 217, 111-123.
21. Patel, A. H., Subak-Sharpe, J. H., Stow, N. D., Marsden, H. S., MacLean, J. B. & Dargan, D. J. (1996b). Suppression of amber nonsense mutations of herpes simplex virus type 1 in a tissue culture system. Journal of General Virology 77, 199-209.
22. Possee, R. D. & Howard, S. C. (1987). Analysis of the polyhedrin gene promoter of the Autographa californica nuclear polyhedrosis virus. Nucleic Acids Research 15, 10233-10248.
23. Quinlan, M. P., Chen, L. B. & Knipe, D. M. (1984). The intranuclear localization of a herpes simplex virus DNA binding protein is determined by the status of viral DNA replication. Cell 36, 857-868.
24. Scheaffer, A. K., Hurlburt, W. W., Stevens, J. T., Bifano, M., Hamatake, R. K., Colonno, R. J. & Tenney, D. J. (1995). Characterization of monoclonal antibodies recognizing amino- and carboxy-terminal epitopes of the herpes simplex virus UL42 protein. Virus Research 38, 305-314.
25. Schenk, P., Pietschmann, S., Gelderblom, H., Pauli, G. & Ludwig, H. (1988). Monoclonal antibodies agains herpes simplex virus type 1-infected nuclei defining and localizing the ICP8 protein, 65 K DNA-binding protein and polypeptides of the ICP35 family. Journal of General Virology 69, 99-111; corrigendum 967.
26. Sherman, G., Gottlieb, J. & Challberg, M. D. (1992). The UL8 subunit of the herpes simplex virus helicase-primase complex is required for efficient primer utilization. Journal of Virology 66, 4884-4892.
27. Stow, N. D. (1982). Localization of an origin of DNA replication within the TRs/IRs repeated region of the herpes simplex type 1 genome. EMBO Journal 1, 863-867.
28. Stow, N. D. (1992). Herpes simplex virus type 1 origin-dependent DNA replication in insect cells using recombinant baculoviruses. Journal of General Virology 73, 313-321.
29. Stow, N. D. (1993). Sequences at the C-terminus of the herpes simplex virus type 1 UL30 protein are dispensable for DNA polymerase activity but not for viral origin-dependent DNA replication. Nucleic Acids Research 21, 87-92.
30. Tenney, D. J., Hurlburt, W. W., Bifano, M., Stevens, J. T., Micheletti, P. A., Hamatake, R. K. & Cordingley, M. G. (1993). Deletions of the carboxy terminus of herpes simplex virus type 1 UL42 define a conserved amino-terminal functional domain. Journal of Virology 67, 1959-1966.
31. Tenney, D. J., Hurlburt, W. W., Micheletti, P. A., Bifano, M. & Hamatake, R. K. (1994). The UL8 component of the herpes simplex virus helicase-primase complex stimulates primer synthesis by a subassembly of the UL5 and UL52 components. Journal of Biological Chemistry 269, 5030-5035.
32. Tenney, D. J., Scheaffer, A. K., Hurlburt, W. W., Bifano, M. & Hamatake, R. K. (1995). Sequence-dependent primer synthesis by the herpes simplex virus helicase-primase complex. Journal of Biological Chemistry 270, 9129-9136.
33. Weller, S. K. (1991). Genetic analysis of HSV genes required for genome replication. In Herpesvirus Transcription and its Regulation, pp. 105-135. Edited by E. K. Wagner. Boca Raton: CRC Press.
34. Weller, S. K., Spadaro, A., Schaffer, J. E., Murray, A. W., Maxam, A. M. & Schaffer, P. A. (1985). Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis. Molecular and Cellular Biology 5, 930-942.
35. Whu, C. A., Nelson, N. J., McGeoch, D. J. & Challberg, M. D. (1988). Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. Journal of Virology 62, 435-443.
36. Zhu, L. & Weller, S. K. (1992). The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase primase, are essential for its function. Journal of Virology 66, 469-479.