Activation of purinergic P2Y2 receptors inhibits inducible NO synthase in cultured rat mesangial cells

American Journal of Physiology - Renal Physiology

Volumn 275, Issue 1 44-1, 1998, Pages

  Mohaupt, Markus G ^a,b   Fischer, Tina ^a   Schwöbel, Jörg ^a   Sterzel, R Bernd ^a   Schulze Lohoff, Eckhard ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Glomerular inflammation; Inducible nitric oxide synthesis; Protein kinase C; Purinergic receptors

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHORBOL 13 ACETATE 12 MYRISTATE; PURINE P2 RECEPTOR; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; GLOMERULONEPHRITIS; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

EID: 0031843810     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1998.275.1.f103     Document Type: Article

References (48)

1. Abboud, H. E. Resident glomerular cells in glomerular injury: mesangial cells. Semin. Nephrol. 11: 304-310, 1991.
2. Ballermann, B. J., and P. A. Marsden. Endothelium-derived vasoactive mediators and renal glomerular function. Clin. Invest. Med. 14: 508-517, 1991.
3. Burnstock, G. Development and perspectives of the purinoceptor concept. J. Auton. Pharmacol. 16: 295-302, 1996.
4. Burnstock, G. Dual control of local blood flow by purines. Ann. NY Acad. Sci. 603: 31-44, 1990.
5. Burnstock, G, and B. F. King. The numbering of cloned P2 purinoceptors. Drug. Dev. Res. 38: 67-71, 1996.
6. Cattell, V., T. Cook, and S. Moncada. Glomeruli synthezise NO in experimental nephrotoxic nephritis. Kidney Int. 38: 1056-1060, 1990.
7. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
8. Denlinger, L. C., P. L. Fisette, K. A. Garis, G. Kwon, A. Vazquez-Torres, A. D. Simon, B. Nguyen, R. A. Proctor, P. J. Bertics, and J. A. Corbett. Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. J. Biol. Chem. 271: 337-342, 1996.
9. Diaz-Guerra, M. J., O. G. Bodelon, M. Velasco, R. Whelan, P. J. Parker, and L. Bosca. Up-regulation of protein kinase C-ε promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells. J. Biol. Chem. 271: 32028-32033, 1996.
10. Fredholm, B. B., M. P. Abbracchio, G. Burnstock, G. R. Dubyak, T. K. Harden, K. A. Jacobson, U. Schwabe, and M. Williams. Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol. Sci. 18: 79-82, 1997.
11. Gordon, J. L. Extracellular ATP: effects, sources and fate. Biochem. J. 233: 309-319, 1986.
12. Goto, S., T. Yamamoto, L. Feng, E. Yaoita, S. Hirose, H. Fujinaka, K. Kawasaki, R. Hattori, Y. Yui, C. B. Wilson, M. Arakawa, and I. Kihara. Expression and localization of inducible nitric oxide synthase in anti-Thy-1 glomerulonephritis. Am. J. Pathol. 147: 1133-1141, 1995.
13. Green, L. C., D. A. Wagner, J. Glogowski, P. L. Skipper, J. S. Wishnok, and S. R. Tannenbaum. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126: 131-138, 1982.
14. Greenberg, S. S., X. Zhao, J. F. Wang, L. Hua, and J. Ouyang. cAMP and purinergic P2y receptors upregulate and enhance inducible NO synthase mRNA and protein in vivo. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L967-L979, 1997.
15. Grierson, J. P., and J. Meldolesi. Shear stress-induced [Ca2+]i transients and oscillations in mouse fibroblasts are mediated by endogenously released ATP. J. Biol. Chem. 270: 4451-4456, 1995.
16. Herold, C. L., Q. Li, J. B. Schachter, T. K. Harden, and R. A. Nicholas. Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7. Biochem. Biophys. Res. Commun. 235: 717-721, 1997.
17. Hofmann, J. The potential for isoenzyme-selective modulation of protein kinase C. FASEB J. 11: 649-669, 1997.
18. Huwiler, A., and J. Pfeilschifter. Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells. Br. J. Pharmacol. 113: 1455-1463, 1994.
19. Ishikawa, S., M. Kawasumi, I. Kusaka, N. Komatu, N. Iwao, and T. Saito. Extracellular ATP promotes cellular growth of glomerular mesangial cells mediated by phospholipase C. Biochem. Biophys. Res. Commun. 202: 234-240, 1994.
20. Ishimura, E., R. B. Sterzel, K. Budde, and M. Kashgarian. Formation of an extracellular matrix by cultured mesangial cells. Am. J. Pathol. 134: 843-855, 1989.
21. Jansen, A., T. Cook, M. Taylor, P. Largen, V. Riveros-Moreno, S. Moncada, and V. Cattell. Induction of nitric oxide synthase in rat immune complex glomerulonephritis. Kidney Int. 45: 1215-1219, 1994.
22. Johnson, R. J. The glomerular response to injury: progression or resolution? Kidney Int. 45: 1769-1782, 1994.
23. Kone, B. C., and C. Baylis. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am. J. Physiol. 272 (Renal Physiol. 41): F561-F578, 1997.
24. Li, Q., J. B. Schachter, T. K. Harden, and R.A. Nicholas. The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Biochem. Biophys. Res. Commun. 236: 455-460, 1997.
25. Lovett, D. H., J. L. Ryan, and R. B. Sterzel. A thymocyte-activating factor derived from glomerular mesangial cells. J. Immunol. 130: 1796-1801, 1983.
26. Lustig, K. D., A. K. Shiau, A. J. Brake, and D. Julius. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. USA 90: 5113-5117, 1993.
27. Marsden, P. A., and B. J. Ballermann. Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. J. Exp. Med. 172: 1843-1852, 1990.
28. Mohaupt, M. G., J. L. Elzie, K. Y. Ahn, W. L. Clapp, C. S. Wilcox, and B. C. Kone. Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney. Kidney Int. 46: 653-665, 1994.
29. Muhl, H., and J. Pfeilschifter. Possible role of protein kinase C-ε isoenzyme in inhibition of interleukin-1 induction of nitric oxide synthase in rat mesangial cells. Biochem. J. 303: 607-612, 1994.
30. Narita, I., W. A. Border, M. Ketteler, and N. A. Noble. Nitric oxide mediates immunologic injury to kidney mesangium in experimental glomerulonephritis. Lab. Invest. 72: 17-24, 1995.
31. Paul, A., K. Doherty, and R. Plevin. Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells. Br. J. Pharmacol. 120: 940-946, 1997.
32. Pavenstädt, H., J. Gloy, J. Leipziger, B. Klär, J. Pfeilschifter, P. Schollmeyer, and R. Greger. Effects of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture. Br. J. Pharmacol. 109: 953-959, 1993.
33. Pfeilschifter, J. Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. Biochem. J. 272: 469-472, 1990.
34. Pfeilschifter, J., and A. Huwiler. Regulatory functions of protein kinase C isoenzymes in purinoceptor signalling in mesangial cells. J. Auton. Pharmacol. 16: 315-318, 1996.
35. Pfeilschifter, J., and H. Schwarzenbach. Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells. FEBS Lett. 273: 185-187, 1990.
36. Poelstra, K., E. R. Heynen, J. F. Baller, M. J. Hardonk, and W. W. Bakker, Modulation of anti-Thy1 nephritis in the rat by adenine nucleotides. Evidence for an anti-inflammatory role for nucleotidases. Lab. Invest. 66: 555-563, 1992.
37. Schulze-Lohoff, E., M. Bitzer, A. Ogilvie, and R. B. Sterzel. P2U purinergic receptor activation mediates inhibition of cAMP accumulation in cultured renal mesangial cells. Renal Physiol. Biochem. 18: 219-230, 1995.
38. Schulze-Lohoff, E., C. Hugo, S. Rost, K. Chang, Y. Takuwa, A. Ogilvie, and R. B. Sterzel. UDP increases intracellular calcium, c-fos expression and DNA synthesis in mesangial cells via specific UDP receptors (Abstract). J. Am. Soc. Nephrol. 8: A407, 1997.
39. Schulze-Lohoff, E., S. Schagerl, A. Ogilvie, and R. B. Sterzel. Extracellular ATP augments mesangial cell growth induced by multiple growth factors. Nephrol. Dial. Transplant. 10: 2027-2034, 1995.
40. Schulze-Lohoff, E., S. Zanner, A. Ogilvie, and R. B. Sterzel. Extracellular ATP stimulates proliferation of cultured mesangial cells via P2-purinergic receptors. Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F374-F383, 1992.
41. Shultz, P. J., S. L. Archer, and M. E. Rosenberg. Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells. Kidney Int. 46: 683-689, 1994.
42. Sterzel, R. B., E. Schulze-Lohoff, and M. Marx. Cytokines and mesangial cells. Kidney Int. 43: S26-S31, 1993.
43. Stuer, D. J., and M. A. Marietta. Mammalian nitrite biosynthesis: mouse macrophage produce nitrate and nitrite in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA 82: 7738-7742, 1985.
44. 2+-inhibited bone resorption. Endocrinology 138: 2148-2162, 1997.
45. Tokuyama, Y., M. Kara, E. M. C. Jones, Z. Fan, and G. I. Bell. Cloning of rat and mouse P2y purinoceptors. Biochem. Biophys. Res. Commun. 211: 211-218, 1995.
46. Tonetti, M., L. Sturla, T. Bistolfi, U. Benatti, and A. De Flora. Extracellular ATP potentiates nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 murine macrophages. Biochem. Biophys. Res. Commun. 203: 430-435, 1994.
47. G-monomethyl-L-arginine. J. Exp. Med. 179: 651-660, 1994.
48. Xie, Q. W., and C. Nathan. Promoter of the mouse gene encoding calcium independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. Trans. Assoc. Am. Phys. 106: 1-12, 1993.