Design and synthesis of small molecule interleukin-1 receptor antagonists based on a benzene template

Drug Design and Discovery

Volumn 15, Issue 3, 1998, Pages 191-198

  Sarabu, Ramakanth ^a   Cooper, Joel P ^a   Cook, Charles M ^a   Gillespie, Paul ^a   Perrotta, Agostino V ^a   Olson, Gary L ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Benzene template; Drug design; IL 1; Peptide mimetics; Pharmacophore hypothesis

Indexed keywords

BENZENE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA;

ARTICLE; COMPUTER PROGRAM; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

BENZENE DERIVATIVES; CATALYSIS; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, INTERLEUKIN-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031841054     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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