Alternatives to the 2-species bioassay for the identification of potential human carcinogens

Human & Experimental Toxicology

Volumn 15, Issue 3, 1996, Pages 183-202

  Ashby, J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

carcinogenicity; genotoxic; human; non genotoxic; p53

Indexed keywords

CARCINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CARCINOGENICITY; CHEMICAL STRUCTURE; DATA BASE; EXPOSURE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; TIME;

ANIMALS; BIOLOGICAL ASSAY; CARCINOGENICITY TESTS; HUMANS; NEOPLASMS, EXPERIMENTAL; SPECIES SPECIFICITY;

EID: 0030003437     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719601500301     Document Type: Article

References (67)

1. Anon. Bioassay of glycidol for rodent carcinogenicity. NTP report, TR 374, NIH Washington, 1990.
2. Anon. Bioassay of limonene for rodent carcinogenicity. NTP report, RT 347, NIH Washington, 1990.
3. Ames BN, Gold LS Too many rodent carcinogens. Science 1990; 249: 970-971.
4. Ashby J. Two million rodent carcinogens? The role of SAR and QSAR in their detection. Mut Res 1994; 305: 3-13.
5. Ashby J., Tennant RW Prediction of rodent carcinogenicity for 44 chemicals: results. Mutagenesis 1994; 9: 7-15.
6. Miller JA, Miller EC Ultimate carcinogens as reactive mutagenic electrophiles, In Hiatt HH, Watson JD and Winstein JA (Eds). Origins of Human Cancer. Cold Spring Harbor Laboratory, NY pp. 605-628, 1977.
7. Vogel EW Nucleophilic selectivity of carcinogens as a determinant of enhanced mutational response. Carcinogenesis 1989; 10: 2093-2106.
8. Ashby J., Tennant RW Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the US NTP. Mutat Res 1991; 257: 229-306.
9. Tennant RW, Ashby J. Classification according to chemical structure of a further 39 chemicals tested for carcinogenicity by the US NTP, Mutation Res 1991; 257: 209-227. Corrigendum. Mutation Res 1991; 317: 175.
10. Ashby J., Paton D. The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 human carcinogen exposures. Mutat Res 1993; 286: 3-74.
11. Dipple A. DNA adducts of chemical carcinogens. Carcinogenesis 1995; 16: 437-442.
12. Richard AM Application of SAR methods to noncongeneric databases: Issues and approaches. Mutat Res 1994; 305: 73-98.
13. Ashby J. et al. Mechanistic relationship between mutagenicity, skin sensitisation and skin carcinogenicity. Environ Health Perspect 1993; 101: 62-67.
14. Phillips DH et al. α-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Research 1994; 54: 5518-5522.
15. Anon. Bioassay of titanium dioxide for rodent carcinogenicity, NTP Tech. report 97, 1979.
16. Tennant RW et al. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 1987; 236: 933-941.
17. Vainio H., Coleman M., Wilbourn J. Carcinogenicity evaluation and ongoing studies: The IARC database. Environ Hlth Perspect 1991; 96: 5-9.
18. Shelby MD The genetic toxicity of human carcinogens and its implications. Mutat Res 1988; 204: 3-17.
19. Tinwell H., Ashby J. Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay. Environ Hlth Perspect 1994; 102: 758-763.
20. Ashby J. The prospects for an internationally harmonised approach to the prediction of possible human carcinogens and mutagens. Mutagenesis 1986; 1: 3-16.
21. Fairbarn DW, Olive PL, O'Neill KL The comet assay: A comprehensive review. Mutat Res 1995; 339: 37-59.
22. Sullivan N., Gatehouse D., Tweats D. Mutation, cancer and transgenic models. Mutagenesis 1993; 8: 167-174.
23. Mirsalis J., Monforte JA, Winegar RA Transgenic animal models for measuring mutations in vivo. Crit Rev in Toxicol 1994; 24: 255-280.
24. Morrison V., Ashby J. A preliminary evaluation of the performance of the Muta TM Mouse (lac Z) and Big Blue™ (lac I) transgenic mouse mutation assays. Mutagenesis 1994; 9: 367-375.
25. Mackay JM, Elliott BM Dose-ranging and dose-setting for in vivo genetic toxicology studies. Mut Res 1992; 271: 97-99.
26. Morrison V., Ashby J. Reconciliation of five negative and four positive reports of the activity of dimethylnitrosamine in the mouse bone marrow micronucleus assay. Mutagenesis 1994; 9: 361-365.
27. Shelby MD, Erexson GL, Hood GJ, Tice RR Evaluation of a three exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen 1993; 21: 160-179.
28. Farber E. Cellular biochemistry of the stepwise development of cancer with chemicals, GHA Clowes Memorial Lecture. Cancer Res 1984; 44: 5463-5474.
29. Brambilla G., Mattioli F., Robbiano L., Martelli A. DNA damaging activity of lindane in primary cultures of rat and human hepatocytes, AACR Abstracts, 783, 1995.
30. Pool-Zobel BL et al. Detection of genotoxic effects in human gastric and nasal mucosa cells isolated from biopsy samples. Environ Molec Mutagen 1994; 24: 23-45.
31. Zeise L., Crouch Eac, Wilson R. A possible relationship between toxicity and carcinogenicity. J Am Coll Toxicol 1986; 5: 137-151.
32. Hildebrand B (ed). Early indicators of non-genotoxic carcinogenesis. Mut Res 1991; 248: 211-374.
33. Mackay JM et al. Trichloroacetic acid: investigation into the mechanism of chromosomal damage. Carcinogenesis 1995; 16: 1127-1133.
34. Ferreira-Gonzalez A., De Angelo AB, Nasim S., Garrett CT Rat oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids. Carcinogenesis 1995; 16: 495-501.
35. Ashby J., Morrod RS Detection of human carcinogens. Nature 1991; 352: 185-186.
36. Swenberg JA α2μ-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment. Environ Hlth Perspect 1993; 101: (Suppl. 6), 39-44.
37. Hard GC, Whysner J. Risk assessment of d-limonene: An example of male rat-specific renal tumourigens. Crit Rev in Toxicol 1994; 24: 231-254.
38. Perera FP Perspectives on the risk assessment for non-genotoxic carcinogens and tumour promoters. Environ Hlth Perspect 1991; 94: 231-235.
39. Ashby J. Change the rules for food additives. Nature 1994; 368: 582.
40. Butterworth B. Consideration of both genotoxic and non-genotoxic mechanisms in predicting carcinogenic potential. Mut Res 1990; 239: 117-132.
41. Lee YW et al. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Molecular and Cellular Biology 1995; 15: 2547-2557.
42. English JC, Hill T., O'Donogue JL, Reddy V. Measurement of nuclear DNA modificatin by 32P postlabelling in the kidneys of male and female F344 rats after multiple gavage doses of hydroquinone. Fund Appl Tox 1994; 23: 391-396.
43. Ashby J., Purchase Ifh. Non-genotoxic carcinogens - an extension of the perspective provided by Perera. Environ Health Perspect 1992; 98: 223-226.
44. Mitchell JR et al. Acetamidophen induced hepatic necrosis. J Pharmacol and Expt Therap 1973; 187: 211-217.
45. Anon. Toxicology and carcinogenesis studies of acetaminophen in F344/N rats and B6C3F 1 mice (feed studies): US National Toxicology Program, TR 394, Washington, 1993.
46. Anon. Toxicology and carcinogenesis studies of benzyl acetate. NTP Technical Report 250, 1986.
47. Anon. Toxicology and carcinogenesis studies of benzyl acetate. NTP Technical Report 431, 1993.
48. Anon. Carcinogenicity database, CMR Annual Report, Centre for Medicines Research, Carshalton, Surrey, 1994.
49. Haseman JK, Lockhart A. The relationship between use of the maximum tolerated dose and study sensitivity for detecting rodent carcinogenicity. Fund Appl Toxicol 1994; 22: 382-391.
50. Apostolou A. Relevance of maximum tolerated dose to human carcinogenic risk. Reg Tox and Pharm 1990; 11: 66-80.
51. Rosenkranz HS, Klopman G. Decreased electrophilicity of chemicals only carcinogenic at the maximum tolerated dose. Mutation Research 1992; 282: 241-246.
52. Rosenkranz HS, Klopman G. Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents. Environmental and Molecular Mutagenesis 1993; 204: 3-17.
53. Faccini JM et al. IFSTP guidelines for the design and interpretation of the chronic rodent carcinogenicity bioassay. Exp Toxic Pathol 1992; 44: 443-456.
54. Haseman JK, Huff JE Species correlation in long-term carcinogenicity studies. Cancer Letters 1987; 37: 125-132.
55. Haseman JK, Lockhart A. Correlations between chemically related site-specific carcinogenic effects in long term studies in rats and mice. Environ Hlth Perspect 1993; 103: 50-55.
56. Gold LS, Bernstein L., Magaw R., Slone TH Inter-species extrapolation in carcinogenesis: prediction between rats and mice. Environ Hlth Perspect 1989; 81: 211-219.
57. Ashby J. Benzyl acetate: from mutagenic carcinogen to non-mutagenic non-carcinogen in 7 years? Mutation Research 1995; 306: 107-109.
58. Davies TS, Monro A. Marketed human pharmaceuticals reported to be tumorigenic in rodents. J Am College Toxicol 1995; 14: 90-107.
59. Tennant RW, French JE, Spalding JW Transgenic mouse models provide new tools for identifying chemical carcinogens and assessing risk. Environ Hlth Perspect 1995; in press.
60. Festing Mfw. Use of multi-strain assay could improve the NTP carcinogenesis bioassay program. Environ Hlth Perspect 1995; 103: 44-52.
61. French JE et al. Short-term carcinogenesis and mutagenesis studies using p53 deficient (±) mice. Environ Molec Mutagen 1995; 25 (Suppl 25): 16.
62. French JE et al. Hemizygous p53 mice are susceptible to mutagenic, but not to non-mutagenic carcinogens. Environ Hlth Perspect 1995; in press.
63. Ashby J., Paton D. Chemicals for evaluating the sensitivity and specificity of reduced/transgenic rodent cancer bioassay protocols. Mutat Res 1995; 331: 27-38.
64. Ashby J., Purchase Ifh. Will all chemicals be carcinogenic to rodents when adequately evaluated? Mutagenesis 1993; 8: 489-493.
65. Ashby J., Tennant RW Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the US NTP. Mutation Res 1988; 204: 17-115.
66. Goldsworthy TL, Lyght O., Burnett VL, Popp JA Potential role of α2μ-globulin protein droplet accumulation and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene and pentachloroethane. Tox Appl Pharmacol 1987; 96: 367-379.
67. Mirsalis JC et al. Induction of hepatic mutations in lac I transgenic mice. Mutagenesis 1993; 8: 265-271.