Chemo-enzymatic synthesis of a new type of enantiomerically pure carbocyclic nucleoside analogues with strong inhibitory effects on terminal deoxynucleotidyl transferase

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 6, 1998, Pages 701-706

  Theil, Fritz ^a,c   Ballschuh, Sibylle ^a   Flatau, Sabine ^a   Von Janta Lipinski, Martin ^b   Matthes, Eckart ^b  

^a LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Chemo enzymatic synthesis; Enantiomeric carbocyclic nucleoside analogues; Terminal deoxynucleotidyl transferase

Indexed keywords

CARBOCYCLIC NUCLEOSIDE; DNA NUCLEOTIDYLEXOTRANSFERASE; ENZYME INHIBITOR; NUCLEOSIDE DERIVATIVE; TRANSFERASE INHIBITOR;

ARTICLE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; NONHUMAN;

ADENOSINE; ANIMALS; BURKHOLDERIA CEPACIA; CATTLE; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA POLYMERASE BETA; DNA POLYMERASE I; ENZYME INHIBITORS; ESCHERICHIA COLI; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; KINETICS; LIPASE; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0031833635     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00021-2     Document Type: Article

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