Resolution and stereoselective synthesis of the herpes thymidine kinase inhibitor L-653180

Tetrahedron Asymmetry

Volumn 8, Issue 5, 1997, Pages 677-681

  Von Langen, Derek J ^a   Tolman, R L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [2 (HYDROXYMETHYL)CYCLOHEXYLMETHYL]GUANINE; ANTIVIRUS AGENT; ENZYME INHIBITOR; THYMIDINE KINASE;

ARTICLE; DRUG PURIFICATION; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTICAL ROTATION; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 0031053678     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00019-0     Document Type: Article

References (5)

1. Ashton, W. T., Meurer, L. C., Tolman, R. L., Karkas, J. D., Liou, R., Perry, H. C., Czelusniak, S. M., and Klein, R. J. Nucleosides Nucleotides 1989, 8, 1157.
2. Bourne, N., Bravo, F. J., Ashton, W. T., Meurer, L. C., Tolman, R. L., Karkas, J. D., and Stanberry, L. R. Antimicrob. Agents Chemother. 1992, 36, 2020.
3. r = 46.8 min).
4. Hamilton, G. S., Huang, Z., Yang, X.-J., Patch, R. J., Narayanan, B. A., and Ferkany, J. W. J. Org. Chem. 1993, 58, 7263.
5. Laumen, K., and Schneider, M. Tetrahedron Lett. 1985, 26, 2073.