Dopaminergic deficit in amyotrophic lateral sclerosis assessed with [I-123] IPT single photon emission computed tomography

Journal of Neurology Neurosurgery and Psychiatry

Volumn 65, Issue 2, 1998, Pages 263-265

  Borasio, G D ^a   Linke, R ^a   Schwarz, J ^c   Schlamp, V ^a   Abel, A ^a   Mozley, P D ^b   Tatsch, K ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Klinikum Grosshadern ^*

Author keywords

Basal ganglia; Dopamine transporter; Motor neuron disease; Single photon emission tomography

Indexed keywords

COCAINE DERIVATIVE; DOPAMINE TRANSPORTER; IODINE 123; N (3 IODOPROPEN 2 YL) 2BETA CARBOMETHOXY 3BETA (4 CHLOROPHENYL)TROPANE; UNCLASSIFIED DRUG;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG BINDING; HUMAN; IMAGE ANALYSIS; NERVE ENDING; NIGRONEOSTRIATAL SYSTEM; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 0031827799     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.65.2.263     Document Type: Article

References (13)

1. Majoor-Krakauer D, Ottman R, Johnson WG, et al. Familial aggregation of amyotrophic lateral sclerosis, dementia, and Parkinson's disease: evidence of shared genetic susceptibility. Neurology 1994;44:1872-7.
2. Jellinger K. Cytoskeletal pathology of parkinsonism and aging brain. In: Calne DB, Comi G, Grippa D, et al, eds. Parkinsonism and aging. New York: Raven Press, 1989:35-56.
3. Kato S, Oda M, Tanabe H. Diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol 1993;19:300-4.
4. Takahashi H, Snow BJ, Bhatt MH, et al. Evidence for a dopaminergic deficit in sporadic amyotrophic lateral sclerosis on positron emission scanning. Lancet 1993;342: 1016-18.
5. Przedborski S, Dhawan V, Donaldson DM, et al. Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations. Neurology 1996;47:1546-51.
6. Mozley PD, Kim HJ, Gur RC, et al. Iodine-123-IPT SPECT imaging of the CNS dopamine transporters: nonlinear effects of normal aging on striatal uptake values. J Nucl Med 1996;37:1965-70.
7. 123I]IPT and single-photon emission tomography. Eur J Nucl Med 1997; 24:415-21.
8. Eisen A, Calne DB. Amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease: phylogenetic disorders of the human neocortex sharing many characteristics. Can J Neurol Sci 1992;19:117-20.
9. Williams TL, Shaw PJ, Lowe J, et al. Parkinsonism in motor neuron disease: case report and literature review. Acta Neuropathol (Berl) 1995;89:275-83.
10. Hoffmann JM, Shi B, Goodman MM, et al. Correlation of in-vivo and in-vitro dopamine transporter function. Neurology 1997;48(suppl):A62-3.
11. Mozley PD, Stubbs JB, Kim HJ, et al. Dosimetry of an iodine-123-labeled tropane to image dopamine transporters. J Nucl Med 1996;37:151-9.
12. Kung MP, Essman WD, Frederick D, et al. IPT: a novel iodinated ligand for the CNS dopamine transporter. Synapse 1995;20:316-24.
13. Kostic V, Gurney ME, Deng HX, et al. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann Neurol 1997;41:497-504.