Iodine-123-IPT SPECT imaging of CNS dopamine transporters: Nonlinear effects of normal aging on striatal uptake values

Journal of Nuclear Medicine

Volumn 37, Issue 12, 1996, Pages 1965-1970

  Mozley, P David ^a   Kim, Hee Joung ^b   Gur, Ruben C ^b   Tatsch, Klaus ^b   Muenz, Larry R ^b   McElgin, William T ^b   Kung, Mei Ping ^b   Mu, Mu ^b   Myers, Andrew M ^b   Kung, Hank F ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

aging; dopamine transporter; iodine 123 IPT; SPECT

Indexed keywords

DOPAMINE RECEPTOR; IODINE 123; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; AGING; ARTICLE; BINDING AFFINITY; BRAIN FUNCTION; DIAGNOSTIC ACCURACY; DOPAMINERGIC TRANSMISSION; FEMALE; HUMAN; HUMAN EXPERIMENT; IMAGE PROCESSING; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REGRESSION ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; AGED; AGING; CARRIER PROTEINS; CAUDATE NUCLEUS; CORPUS STRIATUM; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; PUTAMEN; REGRESSION ANALYSIS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 12644278314     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Giros B, Caron MG. Molecular characterization of the dopamine transporter. Trends Pharmac Sci 1993;14:43-49.
2. Feldman RS, Quenzer LF. Catecholamines. In: The fundamentals of neuropsychopharmacology. Sunderland, MA: Sinauer Associates, Inc.; 1984: 183-187.
3. Johanson CE, Fischman M. The pharmacology of cocaine related to its abuse. Pharmacol Rev 1989;41:3-52.
4. Donnan GA, Woodhouse DG, Kaczmarczyk SJ. et al. Evidence for plasticity of the dopaminergic system in Parkinsonism. Mol Neurobiol 1991;5:421-433.
5. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyperlocomotion and indifference to cocaine and methamphetamine in mice lacking the dopamine transporter. Nature 1996;379:606-612.
6. 11C]-CFT and PET in a primate model of Parkinsonism. Neuroreport 1992;3(3):265-268.
7. 11C-WIN 35,428 reveals marked decline in mild Parkinson's disease. Ann Neurol 1993;34:423-431.
8. 3H] cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinson's disease. Naunyn-Schmiedeberg's Arch Pharmacol 1985;239:227-235.
9. Innis RB, Seibyl JP, Scanley BE, et al. SPECT imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. Proc Natl Acad Sci USA 1993;90:11965-11969.
10. van Dyck CH, Seibyl JP, Malison RT, et al. Age-related decline in striatal dopamine transporter binding with I-123-b-CIT SPECT. J Nucl Med 1995;36:1175-1181.
11. Volkow ND, Fowler JS, Wang GJ, et al. Decreased dopamine transporters with age in healthy human subjects. Ann Neurol 1994;36:237-239.
12. Volkow ND, Ding Y-S, Fowler JS, et al. Dopamine transporters decrease with age. J Nucl Med 1996;37:554-559.
13. 3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey. Brain Res 1993;611:322-325.
14. 3H]dopamine uptake in rat striatum during aging. J Neurochem 1991;56: 575-579.
15. Lezak MD. Neuropsychological assessment, 2nd ed. New York. NY: Oxford University Press; 1983.
16. Bak JS, Greene RL. Changes in neuropsychological functioning in an aging population. J Consult Clin Psych 1980;48:395-399.
17. Harley JP, Leuthold CA, Matthews CG, Bergs LE. Wisconsin neuropsychological test battery T-score norms for older Veterans Administration Medical Center patients. Madison, WI: CG Matthews; 1980.
18. Heaton RK, Grant I, Matthews CG. Differences in neuropsychological test performance associated with age, education and sex. In: Grant I, Adams KM, eds. Neuropsychological assessment of neuropsychiatric disorders. New York, NY: Oxford University Press; 1986; 100-120.
19. Heaton RK, Grant I, Matthews CG. Comprehensive norms for an expanded Halstead-Reitan Battery. Odessa, FL: Psychological Assessment Resources, Inc.; 1991; 5-13.
20. Goeders NE, Kuhar MJ. Chronic cocaine administration induced opposite changes in dopamine receptors in the striatum and nucleus accumbens. Science 1983;221:773-775.
21. Leenders KL, Salmon EP, Tyrrell P, et al. The nigrostriatal dopaminergic system assessed in vivo by PET in healthy volunteer subjects and patients with Parkinson's disease. Arch Neurol 1990;47:1290-1298.
22. Patel J, Trout SJ, Kruk ZL. Regional differences in evoked dopamine efflux in brain slices of rat anterior and posterior caudate putamen. Arch Pharmacol 1992;346:267-276.
23. Kordower JH, Freeman TB, Snow BJ, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-1124.
24. Kung M-P, Essman WD, Frederick D, et al. IPT: a novel iodinated ligand for the CNS dopamine transporter. Synapse 1995;20:316-324.
25. Goodman MM, Kung M-P, Kabalka GW, Kung HF, Switzer R. Synthesis and characterization of radioiodinated N-(3-lodopropen-l-yl)2B-carbomethoxy-3B-(4-chlorophenyl) tropanes: potential dopamine reuptake site imaging agents. J Med Chem 1994;37:1535-1542.
26. Malison RT, Vessotskie JM, Kung M-P, et al. Striatal dopamine transporter imaging in nonhuman primates with [I-123] IPT SPECT. J Nucl Med 1995;36:2290-2297.
27. Mozley PD, Stubbs JB, Kim H-J, et al. Biodistribution and dosimetry of [I-123]-labeled IPT. J Nucl Med 1996;37:151-160.
28. Kim H-J, Karp JS, Mozley PD, et al. Simulating Tc-99m cerebral perfusion studies with a three-dimensional Hoffman brain phantom, collimator and filter selection in SPECT neuroimaging. Ann Nucl Med 1996;10:153-160.
29. Kim HJ, Karp JS, Kung HF, Mozley PD. Quantitative effects of a count rate dependent Wiener filter on image quality: a basal ganglia phantom study simulating [I-123] dynamic SPECT imaging [Abstract]. J Nucl Med 1993;34(suppl):190.
30. Chang LT. A method for attenuation correction in radionuclide computed tomography. IEEE Trans Nucl Sci 1978;NS-25:638-643.
31. Resnick SR, Karp JS, Turetsky BI, Gur RE. Comparison of anatomically defined versus physiologically based regional localization: effects on PET-FDG quantitation. J Nucl Med 1993;34:2201-2207.
32. 11C]-raclopride. Ann New York Acad Sci 1993;695:81-85.
33. 11C-raclopride. Neurology 1993;50:474-480.
34. Martin WRW, Palmer MR, Patlak CS, Calne DB. Nigrostriatal function in man studied with PET. Ann Neurol 1989;26:535-542.
35. Sawle GV, Colebatch JG, Shah A, et al. Striatal function normal aging: Implications for Parkinson's disease. Ann Neurol 1990;28:799-804.
36. Cordes M, Snow BJ, Cooper S, et al. Age-dependent decline of nigrostriatal dopaminergic function: a PET study of grandparents and their grandchildren. Ann Neurol 1994;36:667-670.
37. Vingerhoets FJG, Snow BJ, Lee CS, Schulzer M, Mak E, Calne DB. Longitudinal fluorodopa PET studies of the evolution of idiopathic Parkinsonism. Ann Neurol 1994;36:759-764.
38. Eidelberg D, Takikawa S, Dhawan V, et al. Striatal fluorine-18-DOPA uptake: absence of an aging effect. J Cereb Blood Flow Metab 1993;13:881-888.
39. Choi BC. Definition, sources, magnitude, effect modifiers and strategies of reduction of the healthy worker effect. J Occup Med 1993;35:890-892.
40. Blanc PD, Katz P, Yelin E. Mortality risk among elderly workers. Am J Industrial Med 1994;26:543-547.
41. Arrighi MH, Hertz-Picciotto I. The evolving concept of the healthy worker survivor effect. Epidemiology 1994;5:189-196.
42. Kim H-J, Mozley PD, McElgin W, et al. In vivo quantification of presynaptic dopamine transporter binding parameters in human brains with [I-123]IPT SPECT [Abstract]. J Nucl Med 1995;36(suppl):125P.
43. Kim H-J, Mozley PD, Kung M-P. et al. Absolute activity measurements of in vivo monkey brain using a triple-headed SPECT and a new radioligand: [I-123]IPT [Abstract]. J Nucl Med 1995;36(suppl):178-179.
44. Kushner SA, Frederick D, Kung M-P, et al. Quantitative [I-123]IPT SPECT measurements: comparisons with ex vivo dissection and in vitro binding assays in nonhuman primates [Abstract]. J Nucl Med 1996;37(suppl):66P.