Diverging evolution of anti-GAD and anti-IA-2 antibodies in long- standing diabetes mellitus as a function of age at onset: No association with complications

Diabetic Medicine

Volumn 15, Issue 7, 1998, Pages 586-591

  Hermitte, L ^a   Atlan Gepner, C ^a,b   Mattei, C ^b,c   Dufayet, D ^a   Jannot, M F ^c   Christofilis, M A ^b   Nervi, S ^a   Vialettes, B ^a,b,d  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Service de Nutrition   (France)

^c TIMONE HOSPITAL   (France)

^d HÔPITAL SAINTE MARGUERITE   (France)

Author keywords

Diabetes complication; Diabetes mellitus; Glutamic acid decarboxylase (GAD); Tyrosine phosphatase (IA 2)

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; AUTOIMMUNITY; CHILD; CLINICAL ARTICLE; DIABETES MELLITUS; ENVIRONMENTAL FACTOR; FEMALE; HUMAN; HUMORAL IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROALBUMINURIA; ONSET AGE; PANCREAS ISLET BETA CELL; PREPUBERTY; PREVALENCE; RETINA ANGIOGRAPHY; VASCULAR DISEASE;

ADOLESCENT; AGE FACTORS; AUTOANTIBODIES; CHILD; DIABETES MELLITUS, TYPE 1; DIABETIC ANGIOPATHIES; GLUTAMATE DECARBOXYLASE; HUMANS; PROTEIN-TYROSINE-PHOSPHATASE; PUBERTY; TIME FACTORS;

EID: 0031826139     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199807)15:7<586::AID-DIA624>3.0.CO;2-B     Document Type: Article

References (24)

1. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M. A comparison of childhood and adult type I diabetes mellitus. N Engl J Med 1989; 320: 880-886.
2. Caillat-Zucman S, Garchon HJ, Timsit J, Assan R, Boitard C, Djilali-Saiat I et al. Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest 1992; 90: 2242-2250.
3. Vandewalle CL, Decraene T, Schuit FC, De Leeuw IH, Pipeleers D, Gorus FK et al. Insulin antibodies and high titre of islet cell antibodies are preferentially associated with the HLA DQ A1*0301 DQB1* 0302 haplotype at clinical onset of type 1 (insulin-dependent) diabetes mellitus before age 10 years but not at onset between age 10 and 40 years. Diabetologia 1993; 36: 1155-1162.
4. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ et al. Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 1995; 38: 816-822.
5. Laws HW, Harpur ER, Belmonte MM, Adams KW. A long term study of retinal changes in the pre-puberty and puberty onset diabetic. Can J Ophtal 1966; 1: 104-111.
6. Krolewsky AS, Warram JH, Christlieb AR, Busick EJ, Kahn CR. The changing natural history of nephropathy in type 1 diabetes. Am J Med 1985; 78: 785-794.
7. Kostraba JN, Dorman JS, Orchard TJ, Becker DJ, Ohki Y, Ellis D et al. Contribution of diabetes duration before puberty to development of microvascular complications in IDDM subjects. Diabetes Care 1989; 12: 686-693.
8. The Diabetes Control and Complications Trial Research Group. The eftect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Eng J Med 1993; 329: 977-986.
9. The Diabetes Control and Complications Trial Research Group. Factors in development of diabetic neuropathy. Baseline analysis of neuropathy in feasibility phase of diabetes control and complications trial (DCCT). Diabetes 1988; 37: 476-481.
10. Vague P, Dufayet D, Coste T, Moriscot C, Jannot MF, Raccah D. Association of diabetic neuropathy with NA/K ATPase gene polymorphism. Diabetologia 1997; 40: 506-511.
11. Sundkvist G, Velloso L, Kämpe O, Rabinowe S, Ivarsson S, Lilja B et al. Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients. Diabetologia 1994; 37: 293-299.
12. Roll U, Nuber A, Schröder A, Gerlach E, Jancha HU, Ziegler A. No association of antibodies to glutamic acid decarboxylase and diabetic complications in patients with IDDM. Diabetes Care 1995; 18: 210-215.
13. Vinik A, Leichter S, Pittenger G, Stanberry K, Holland MT, Powers A et al. Phospholipid and glutamic acid decarboxylase autoantibodies in diabetic neuropathy. Diabetes Care 1995; 18: 1225-1232.
14. 65 and IA-2 autoantibodies in IDDM patients affected by diabetic nephropathy. Diabetologia 1997; 40: 485.
15. Muhr D, Mollenhauer U, Ziegler AG, Halsbeck M, Standl E, Schnell O. Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy. Diabetes Care 1997; 20: 1009-1012.
16. Irvine WJ, McCallum CJ, Gray RS, Campbell CJ, Duncan LJP, Farquhar JW et al. Pancreatic islet cell autoantibodies in diabetes mellitus correlated with the duration and type of diabetes coexistent autoimmune disease and HLA type. Diabetes 1977; 26: 138-147.
17. 65 autoantibodies in new onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia 1997; 40: 95-99.
18. Seissler J, Morgenthaler N, Adenbach P, Lampeter E, Glawe D, Payton M et al. Combined screening for autoantibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. Diabetologia 1996; 39: 1351-1356.
19. 65 and IA-2 autoantibodies in IDDM can replace the histochemical islet cell antibody test. Diabetes 1997; 46: 132-134.
20. Yokota I, Shirakawa N, Shima K, Matsuda J, Naito E, Ito M et al. Relationship between GAD antibody and residual β-cell function in children after overt onset of IDDM. Diabetes Care 1996; 19: 74-75.
21. Clare-Saltzer MJ, Tobin AJ, Kaufman DL. Glutamate decarboxylase: an autoantigen in IDDM. Diabetes Care 1992; 15: 132-134.
22. Banatvala JE, Bryant J, Schernthaner D, Borkensteine M, Schober E, Brown D, et al. Coxsackie B, mumps, rubella and cytomegalovirus specific IgM responses in patients with juvenile onset (insulin-dependent) diabetes mellitus in Britain, Austria and Australia. Lancet 1985; 1: 1409-1412.
23. Karjalainen J, Knip M, Hyoty H, Lernikki P, Ilonen J, Kaar ML, et al. Relationship between serum insulin antibodies, islet cell antibodies and Coxsackie B4 and mumps virus-specific antibodies at the clinical manifestation of type 1 (insulin-dependent) diabetes. Diabetologia 1988; 31: 146-152.
24. Tuomi T, Zimmet PZ, Rowley MJ, Serjeantson SW, Mackay IR. Persisting antibodies to glutamic acid decarboxylase in type 1 (insulin-dependent) diabetes mellitus are not associated with neuropathy (Letter). Diabetologia 1993; 36: 685.