Nocturnal excretion of a urinary melatonin metabolite among electric utility workers

Scandinavian Journal of Work, Environment and Health

Volumn 24, Issue 3, 1998, Pages 183-189

  Burch, James B ^a   Reif, John S ^a   Yost, Michael G ^b   Keefe, Thomas J ^a   Pitrat, Charles A ^a  

^a Immunology and Pathology   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

6 Hydroxymelatonin sulfate; 60 Hz; Electromagnetic fields; Human; Magnetic fields; Pineal

Indexed keywords

6 HYDROXYMELATONIN O SULFATE; CREATININE; MELATONIN DERIVATIVE;

ADULT; ARTICLE; ELECTRIC POWER PLANT; ELECTROMAGNETIC FIELD; ENVIRONMENTAL EXPOSURE; HOME; HUMAN; INDUSTRIAL WORKER; LIGHT EXPOSURE; MAGNETIC FIELD; MAJOR CLINICAL STUDY; MALE; NIGHT; PRIORITY JOURNAL; QUESTIONNAIRE; SLEEP; STATISTICAL ANALYSIS; TEMPORAL LOBE; URINARY EXCRETION; URINE LEVEL; WORK ENVIRONMENT;

EID: 0031825632     PISSN: 03553140     EISSN: None     Source Type: Journal    
DOI: 10.5271/sjweh.297     Document Type: Article

References (60)

1. Reiter RJ. Alterations of the circadian melatonin rhythm by the electromagnetic spectrum: a study in environmental toxicology. Regul Toxicol Pharmacol 1992;15:226-44.
2. Cagnacci A. Melatonin in relation to physiology in adult humans. J Pineal Res 1996;21:200-13.
3. Brezinski A. Melatonin in humans. New Engl J Med 1997;336:186-95.
4. Blask DE. Melatonin in oncology. In: Yu H, Reiter RJ, editors. Melatonin biosynthesis, physiological effects, and clinical applications. Boca Raton (FL): CRC Press, 1993.
5. Panzer A, Viljoen M. The validity of melatonin as an oncostatic agent. J Pineal Res 1997;22:184-202.
6. Conti A, Maestroni GJM. The clinical neuroimmunotherapeutic role of melatonin in oncology. J Pineal Res 1995;19:103-10.
7. Maestroni GJM. The immunoendocrine role of melatonin. J Pineal Res 1993;14:1-10.
8. Guerrero JM, Reiter RJ. A brief survey of pineal glandimmune system interrelationships. Endocr Res 1992;18:91-113.
9. Nelson RJ, Demas GE, Klein SL, Kriegsfeld LJ. The influence of season, photoperiod, and pineal melatonin on immune function. J Pineal Res 1995;19:149-65.
10. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11.
11. Tan DX, Reiter RJ, Chen LD, Poeggeler B, Manchester LC, Barlow-Walden LR. Both physiological and pharmacological levels of melatonin reduce DNA adduct formation in-duced by the carcinogen safrole. Carcinogenesis 1994;15:215-8.
12. Manev H, Tolga U, Kharlamov A, Joo J-Y. Increased brain damage after stroke or excitotoxic seizures in melatonindeficient rats. FASEB J 1996;10:1546-51.
13. Cohen M, Lippman M, Chabner B. Role of the pineal gland in the aetiology and treatment of breast cancer. Lancet 1978;2:814-6.
14. Shah PN, Mhatre MC, Kothari LS. Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods. Cancer Res 1984;44:3403-10.
15. Reiter RJ. Melatonin suppression by static and extremely low frequency electromagnetic fields: relationship to the reported increased incidence of cancer. Rev Environ Health 1994;10:171-86.
16. Wilson BW, Wright CW, Morris JE, Buschbom RL, Brown DP, Miller DL, et al. Evidence for an effect of ELF electromagnetic fields on human pineal gland function. J Pineal Res 1990;9:259-69.
17. Pfluger DH, Minder CE. Effects of exposure to 16.7 Hz magnetic fields on urinary 6-hydroxymelatonin sulfate excretion of Swiss railway workers. J Pineal Res 1996;21:91-100.
18. Deadman JE, Camus M, Armstrong BG, Heroux P, Cyr D, Plante M, et al. Occupational and residential 60-Hz electromagnetic fields and high frequency electric transients: exposure assessment using a dosimeter. Am Ind Hyg Assoc J 1988;49:409-19.
19. Bracken TD. Exposure assessment for power frequency electric and magnetic fields. Am Ind Hyg Assoc J 1993;54:197-204.
20. Sahl JD, Kelsh MA, Smith RW, Aseltine DA. Exposure to 60 Hz magnetic fields in the electric utility work environment. Bioelectromagnetics 1994;15:21-32.
21. Bowman JD, Garabrant DH, Sobel E, Peters JM. Exposures to extremely low frequency electromagnetic fields in occupations with elevated leukemia rates. Appl Ind Hyg 1988;3:189-94.
22. Savitz DA. Overview of epidemiological research on electric and magnetic fields and cancer. Am Ind Hyg Assoc J 1993;54:197-204.
23. Kheiffets LI, Abdelmonem AA, Buffler PA, Zhang ZW. Occupational electric and magnetic field exposure and brain cancer: a meta-analysis. J Occup Environ Med 1995;37:1327-41.
24. Feychting M, Ahlbom A. Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Am J Epidemiol 1993;13:467-81.
25. Floderus B, Persson T, Stenlund C, Linder G, Johansson C, Kiviranta J, et al. Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: a case-control study in Sweden. Cancer Causes Control 1993;4:465-76.
26. Matanoski GM, Elliott EA, Breysse PN, Lynberg MC. Leukemia in telephone linemen. Am J Epidemiol 1993;137:609-19.
27. Lerchl A, Nonaka KO, Reiter RJ. Pineal gland "magneto-sensitivity" to static magnetic fields is a consequence of induced electric currents (eddy currents). J Pineal Res 1991;10:109-16.
28. Rogers WR, Reiter RJ, Smith HD, Barlow-Waiden L. Rapid-onset/offset, variably scheduled 60 Hz electric and magnetic field exposure reduces nocturnal serum melatonin concentration in nonhuman primates. Bioelectromagnetics 1995;3 suppl:119-22.
29. Wilson BW, Lee GM, Yost MG, Davis KC. Heimbigner T, Buschbom RL. Magnetic field characteristics of electric bed heating devices. Bioelectromagnetics 1996;17:174-9.
30. Litovitz TA, Krause D, Mullins JM. Effect of coherence of the applied magnetic field on ornithine decarboxylase activity. Biochem Biophys Res Commun 1991;178:862-5.
31. Litovitz TA, Krause D, Montrose CJ, Mullins JM. Temporally incoherent magnetic fields mitigate the response of biological systems to temporally coherent magnetic fields. Bioelectromagnetics 1994;15:399-409.
32. Litovitz TA, Penafiel M, Krause D, Zhang D, Mullins JM. The role of temporal sensing in bioelectromagnetic effects. Bioelectromagnetics 1997;18:388-95.
33. Arendt J, Bojkowski C, Franey C, Wright J, Marks V. Immunoassay of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol. J Clin Endocrinol Metab 1985;60:1166-73.
34. Aldous ME, Arendt J. Radioimmunoassay for 6-sulphatoxymelatonin in urine using an iodinated tracer. Ann Clin Biochem 1988;25:298-303.
35. Bojkowski CJ, Arendt JA, Shin MC, Markey SP. Melatonin secretion in humans assessed by measuring its metabolite, 6-sulfatoxymelatonin. Clin Chem 1987;33:1343-8.
36. Fellenberg AJ, Phillipou G, Seamark RF. Specific quantitation of urinary 6-hydroxymelatonin sulfate by gas chromatography mass spectrometry. Biomed Mass Spectrom 1980;7:84-7.
37. Wehr TA, Moul DE, Barbato G, Giesen HA, Seidel JA, Barker C, et al. Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol 1993;265:R846-57.
38. Laakso M-L, Porkka-Heiskanen T, Alila A, Stenberg D, Johansson G. Twenty-four-hour rhythms in relation to the natural photoperiod: a field study in humans. J Biol Rhythms 1994;9:283-93.
39. Kollar M, Marma M, Laitinen JT, Kundi M, Piegler B, Haider M. Different patterns of light exposure in relation to melatonin and cortisol rhythms and sleep of night workers. J Pineal Res 1994;16:127-35.
40. Olcese J, Reuss S, Vollrath L. Evidence for the involvement of the visual system in mediating magnetic field effects on pineal melatonin synthesis in the rat. Brain Res 1985;333:382-84.
41. Reuss S, Olcese J. Magnetic field effects on rat pineal gland: role of retinal activation by light. Neurosci Lett 1986;64:97-101.
42. Phillips JB, Deutschlander ME. Magnetoreception in terrestrial vertebrates: implications for possible mechanisms of EMF interaction with biological systems. In: Stevens R, Wilson BW, Anderson LE, editors. The melatonin hypothesis and breast cancer. Columbus (OH): Batelle Press, 1997.
43. Wood AW, Armstrong SM, Sait ML, Devine L, Martin MJ. Changes in human plasma melatonin profiles in response to 50 Hz magnetic field exposure. J Pineal Res. In press.
44. Graham C, Cook MR, Riffle DW, Gerkovich MM, Cohen HD. Nocturnal melatonin levels in human volunteers exposed to intermittent 60 Hz magnetic fields. Bioelectromagnetics 1996;17:263-73.
45. Graham C, Cook MR, Riffle DW. Human melatonin during continuous magnetic field exposure. Bioelectromagnetics 1996;18:166-71.
46. Selmaoui B, Touitou Y. Magnetic fields and pineal function in humans: evaluation of nocturnal acute exposure to extremely low frequency magnetic fields on serum melatonin and urinary 6-sulfatoxymelatonin circadian rhythms. Life Sci 1996;58:1539-49.
47. Selmaoui B, Touitou Y. Sinusoidal 50 Hz magnetic fields depress rat pineal NAT activity and serum melatonin: role of duration and intensity of exposure. Life Sci 1995;57:1351-58.
48. Kato M, Honma K, Shigemitsu T, Shiga Y. Effects of circularly polarized 50-Hz magnetic field on plasma and pineal melatonin levels in rats. Bioelectrormagnetics 1993;14:97-106.
49. Kato M, Honma K, Shigemitsu T, Shiga Y. Circularly polarized 50-Hz magnetic field exposure reduces pineal gland and blood melatonin concentrations in Long-Evans rats. Neurosci Lett 1994;166:59-62.
50. Loescher W, Wahnschaffe U, Mevissen M, Lerchl A, Stamm A. Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats. Oncology 1994;51:288-95.
51. Mevissen M, Lerchl A, Loescher W. Study of pineal function and DMBA-induced breast cancer formation in rats during exposure to a 100-mG, 50 Hz magnetic field. J Toxicol Environ Health 1996;48:169-85.
52. Wilson BW, Chess EK, Anderson LE. 60-Hz electric field effects on pineal melatonin rhythms: time course for onset and recovery. Bioelectromagnetics 1986;7:239-42.
53. Lee JM, Stormshak F, Thompson JM, Thinesen P, Painter LJ, Olenchek EG, Hess DL, Forbes R, Foster DL. Melatonin secretion and puberty in female lambs exposed to environmental electric and magnetic fields. Biol Reprod 1993;49:857-64.
54. Lee JM, Stormshak F, Thompson JM, Hess DL, Foster DL. Melatonin and puberty in female lambs exposed to EMF: a replicate study. Bioelectromagnetics 1995;16:119-23.
55. Rogers WR, Reiter RJ, Smith HD. Barlow-Walden L. Regularly scheduled, day-time, slow-onset 60 Hz electric and magnetic field exposure does not depress serum melatonin concentrations in nonhuman primates. Bioelectromagnetics 1995;3 suppl:111-8.
56. Grata LJ, Reiter RJ, Keng P, Michaelson S. Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats. Bioelectromagnetics 1994;15:427-37.
57. Bakos J, Nagy N, Thuroczy G, Szabo LD. Sinusoidal 50 Hz, 500 μT magnetic field has no acute effect on urinary 6-sulfatoxymelatonin in Wistar rats. Bioelectromagnetics 1995;16:377-80.
58. Truong H, Yellon SM. Effect of various acute 60 Hz magnetic field exposures on the nocturnal melatonin rise in the adult Djungarian hamster. J Pineal Res 1997;22:177-83.
59. Martinez Soriano F, Gimenez Gonzalez M, Armanazas E, Ruiz Torner A. Pineal 'synaptic ribbons' and serum melatonin levels in the rat following the pulse action of 52-Gs (50 Hz) magnetic fields: an evolutive analysis over 21 days. Acta Anatomica 1992;143:289-93.
60. Brainard GC, Lewy AJ, Menaker M, Frederickson RA, Miller LS, Weleber RG, et al. Effect of light wavelength on the suppression of nocturnal plasma melatonin in normal volunteers. Ann NY Acad Sci 1985:453:376-8.