Major antigenic proteins of the agent of human granulocytic ehrlichiosis are encoded by members of a multigene family

Infection and Immunity

Volumn 66, Issue 8, 1998, Pages 3711-3718

  Murphy, Cheryl I ^a   Storey, James R ^a   Recchia, Joanne ^a   Doros Richert, Linda A ^a   Gingrich Baker, Cindy ^a   Munroe, Kenneth ^a   Bakken, Johan S ^b   Coughlin, Richard T ^a   Beltz, Gerald A ^a  

^a Aquila Biopharmaceuticals Inc   (United States)

^b Duluth Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ARTICLE; EHRLICHIOSIS; IMMUNOREACTIVITY; MULTIGENE FAMILY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0031825616     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.8.3711-3718.1998     Document Type: Article

References (29)

1. Alleman, A. R., G. H. Palmer, T. C. McGuire, T. F. McElwain, L. E. Perryman, and A. F. Barbet. 1997. Anaplasma marginale major surface protein 3 is encoded by a polymorphic, multigene family. Infect. Immun. 65:156-163.
2. Anderson, B. E., J. E. Dawson, D. C. Jones, and K. H. Wilson. 1991. Ehrlichia chaffeensis, a new species associated with human ehrlichiosis. J. Clin. Microbiol. 29:2838-2842.
3. Asanovich, K. M., J. S. Bakken, J. E. Madigan, M. Aguero-Rosenfeld, G. P. Wormser, and J. S. Dumler. 1997. Antigenic diversity of granulocytic Ehrlichia isolates from humans in Wisconsin and New York and a horse in California. J. Infect. Dis. 176:1029-1034.
4. Bakken, J. S., J. S. Dumler, S.-M. Chen, M. R. Eckman, L. L. Van Etta, and D. H. Walker. 1994. Human granulocytic ehrlichiosis in the upper Midwest. A new species emerging? JAMA 272:212-218.
5. Bakken, J. S., J. Krueth, C. Wison-Nordskog, R. L. Tilden, K. Asanovich, and J. S. Dumler. 1996. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 275:199-205.
6. Chen, S.-M., J. S. Dumler, J. S. Bakken, and D. H. Walker. 1994. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J. Clin. Microbiol. 32:589-595.
7. Coughlin, R. T., D. Fish, T. N. Mather, J. Ma, C. Pavia, and P. Bulger. 1995. Protection of dogs from Lyme disease with a vaccine containing outer surface protein (Osp) A, Osp B, and the saponin adjuvant QS-21. J. Infect. Dis. 171:1049-1052.
8. Drancourt, M., and D. Raoult. 1994. Taxonomic position of the Rickettsiae: current knowledge. FEMS Microbiol. Rev. 13:13-24.
9. Dumler, J. S., K. M. Asanovich, J. S. Bakken, P. Richter, R. Kimsey, and J. E. Madigan. 1995. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic ehrlichia. J. Clin. Microbiol. 33:1098-1103.
10. Eid, G., D. M. French, A. M. Lundgren, A. F. Barbet, T. F. McElwain, and G. H. Palmer. 1996. Expression of major surface protein 2 antigenic varients during acute Anaplasma marginale rickettsemia. Infect. Immun. 64:836-841.
11. Goodman, J. L., C. Nelson, B. Vitale, J. E. Madigan, J. S. Dumler, T. J. Kurtti, and U. G. Munderloh. 1996. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 334:209-215.
12. Hardalo, C. J., V. Quagliarello, and J. S. Dumler. 1995. Human granulocytic ehrlichiosis in Connecticut: report of a fatal case. Clin. Infect. Dis. 21:910-914.
13. Karlin, S., and S. F. Altschul. 1990. Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes. Proc. Natl. Acad. Sci. USA 87:2264-2268.
14. Karlin, S., and S. F. Altschul. 1993. Applications and statistics for multiple high scoring segments in molecular sequences. Proc. Natl. Acad. Sci. USA 90:5873-5877.
15. Kolbert, C. P., E. S. Bruinsma, A. S. Abdulkarim, E. K. Hofmeister, R. B. Tompkins, S. R. Telford III, P. D. Mitchell, J. Adams-Stich, and D. H. Persing. 1997. Characterization of an immunoreactive protein from the agent of human granulocytic ehrlichiosis. J. Clin. Microbiol. 35:1172-1178.
16. Madigan, J. E., P. J. Richter, R. B. Kimsey, J. E. Barlough, J. S. Bakken, and J. S. Dumler. 1995. Transmission and passage in horses of the agent of human granulocytic ehrlichiosis. J. Infect. Dis. 172:1141-1144.
17. Madigan, J. E., J. E. Barlough, J. S. Dumler, N. S. Schankman, and E. DeRock. 1996. Equine granulocytic ehrlichiosis in Connecticut caused by an agent resembling the human granulocytotropic ehrlichia. J. Clin. Microbiol. 34:434-435.
18. Magnarelli, L. A., J. S. Dumler, J. F. Anderson, R. C. Johnson, and E. Fikrig. 1995. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. J. Clin. Microbiol. 33:3054-3057.
19. Murphy, C. I., et al. Unpublished observations.
20. Nagai, K., and H. C. Thogerson. 1984. Generation of beta-globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia coli. Nature 309:810-812.
21. Nicholson, W. L., J. A. Comer, J. W. Sumner, C. Gingrich-Baker, R. T. Coughlin, L. A. Magnarelli, J. G. Olson, and J. E. Childs. 1997. An indirect immunofluorescence assay using a cell culture-derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis. J. Clin. Microbiol. 35:1510-1516.
22. Ohashi, N., N. Zhi, Y. Zhang, and Y. Rikihisa. 1998. Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect. Immun. 66:132-139.
23. Palmer, G. H., G. Eid, A. F. Barbet, T. C. McGuire, and T. F. McElwain. 1994. The immunoprotective Anaplasma marginale major surface protein 2 is encoded by a polymorphic multigene family. Infect. Immun. 62:3808-3816.
24. Rikihisa, Y. 1991. The tribe Ehrlichieae and ehrlichial diseases. Clin. Microbiol. Rev. 4:286-308.
25. Storey, J. R., L. A. Doros-Richert, C. Gingrich-Baker, K. Munroe, T. N. Mather, R. T. Coughlin, G. A. Beltz, and C. I. Murphy. 1998. Molecular cloning and sequencing of three granulocytic Ehrlichia genes encoding high-molecular-weight immunoreactive proteins. Infect. Immun. 66:1356-1363.
26. Sumner, J. W., W. L. Nicholson, and R. F. Massung. 1997. PCR amplification and comparison of nucleotide sequences from the groESL heat shock operon of Ehrlichia species. J. Clin. Microbiol. 35:2087-2092.
27. Wong, S. J., G. S. Brady, and J. S. Dumler. 1997. Serological responses to Ehrlichia equi, Ehrlichia chafeensis, and Borrelia burgdorferi in patients from New York State. J. Clin. Microbiol. 35:2198-2205.
28. Yeh, M.-T., T. N. Mather, R. T. Coughlin, C. Gingrich-Baker, J. W. Sumner, and R. F. Massung. 1997. Serologic and molecular detection of granulocytic ehrlichiosis in Rhode Island. J. Clin. Microbiol. 35:944-947.
29. Zhi, N., Y. Rikihisa, H. Y. Kim, G. P. Wormser, and H. W. Horowitz. 1997. Comparison of major antigenic proteins of six strains of the human granulocytic ehrlichiosis agent by Western immunoblot analysis. J. Clin. Microbiol. 35:2606-2611.