Production of stabilized virulence factor-negative variants by group A streptococci during stationary phase

Infection and Immunity

Volumn 66, Issue 8, 1998, Pages 3841-3847

  Leonard, B A B ^a,b   Woischnik, M ^a   Podbielski, A ^a  

^a UNIVERSITY OF ULM   (Germany)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRULENCE FACTOR;

ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; BACTERIUM COLONY; BACTERIUM CULTURE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; SEROTYPE; STREPTOCOCCUS GROUP A;

EID: 0031824698     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.8.3841-3847.1998     Document Type: Article

References (59)

1. Anderson, D. G., and L. L. McKay. 1983. Simple and rapid method for isolating large plasmid DNA from lactic streptococci. Appl. Environ. Microbiol. 46:549-552.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1990. Current protocols in molecular biology. Green Publishing Associates and Wiley-Interscience, New York, N.Y.
3. Berge, A., and L. Bjoerck. 1995. Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins. J. Biol. Chem. 270:9862-9867.
4. Betschel, S. D., S. M. Borgia, N. L. Barg, D. E. Low, and J. C. De Azavedo. 1998. Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S. Infect. Immun. 66:1671-1679.
5. Blumenkrantz, N., and G. Asboe-Hansen. 1973. New method for quantitative determination of uronic acids. Anal. Biochem. 54:484-489.
6. Caparon, M. G., R. T. Geist, J. Perez-Casal, and J. R. Scott. 1992. Environmental regulation of virulence in group A streptococci: transcription of the gene encoding M protein is stimulated by carbon dioxide. J. Bacteriol. 174: 5693-5701.
7. Chen, C., and P. P. Cleary. 1990. Complete nucleotide sequence of the streptococcal C5a peptidase gene of Streptococcus pyogenes. J. Biol. Chem. 265:3161-3167.
8. Chuard, C., P. E. Vaudaux, R. A. Proctor, and D. P. Lew. 1997. Decreased susceptibility to antibiotic killing of a stable small colony variant of Staphylococcus aureus in fluid phase and on fibronectin-coated surfaces. J. Antimicrob. Chemother. 39:603-608.
9. Cleary, P. P., D. LaPenta, D. Heath, E. J. Haanes, and C. Chen. 1991. A virulence regulon in Streptococcus pyogenes, p. 151-157. In G. M. Dunny, P. P. Cleary, and L. L. McKay (ed.), Genetics and molecular biology of streptococci, lactococci, and enterococci. American Society for Microbiology, Washington, D.C.
10. Cleary, P. P., L. McLandsborough, L. Ikeda, D. Cue, J. Krawczak, and H. Lam. 1998. High-frequency intracellular infection and erythrogenic toxin A expression undergo phase variation in M1 group A streptococci. Mol. Microbiol. 28:157-167.
11. Cue, D. R., and P. P. Cleary. 1997. High-frequency invasion of epithelial cells by Streptococcus pyogenes can be activated by fibrinogen and peptides containing the sequence RGD. Infect. Immun. 65:2759-2764.
12. Curtis, N. 1996. Invasive group A streptococcal infection. Curr. Opin. Infect. Dis. 9:191-202.
13. Dale, J. B., R. G. Washburn, M. B. Marques, and M. R. Wessels. 1996. Hyaluronate capsule and surface M protein in resistance to opsonization of group A streptococci. Infect. Immun. 64:1495-1501.
14. de Malmanche, S. A., and D. M. Martin. 1994. Protective immunity to the group A streptococcus may be only strain specific. Med. Microbiol. Immunol. 183:299-306.
15. Domingue, G. J., Sr., and H. B. Woody. 1997. Bacterial persistence and expression of disease. Clin. Microbiol. Rev. 10:320-344.
16. Dunny, G. M., P. J. Hedberg, and B. A. B. Leonard. 1995. Pheromone-inducible conjugation in Enterococcus faecalis: interbacterial and host-parasite chemical communication. J. Bacteriol. 177:871-876.
17. Dunny, G. M., and B. A. B. Leonard. 1997. Cell-cell communication in Gram-positive bacteria. Annu. Rev. Microbiol. 51:527-564.
18. Fischetti, V. A. 1997. The streptococcus and the host: present and future challenges. ASM News 10:541-545.
19. Fluckiger, U., K. F. Jones, and V. A. Fischetti. 1998. Immunoglobulins to group A streptococcal surface molecules decrease adherence to and invasion of human pharyngeal cells. Infect. Immun. 66:974-979.
20. Freimer, E. H., R. M. Krause, and M. McCarty. 1959. Studies of L forms and protoplasts of group A streptococci. I. Isolation, growth and bacteriologic characteristics. J. Exp. Med. 110:853-873.
21. Fugua, W. C., S. C. Winans, and E. P. Greenberg. 1994. Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators. Annu. Rev. Microbiol. 50:727-751.
22. Greco, R., L. De Martino, G. Donnarumma, M. P. Conte, L. Seganti, and P. Valenti. 1995. Invasion of cultured human cells by Streptococcus pyogenes. Res. Microbiol. 146:551-560.
23. Herwald, H., M. Collin, W. Mueller-Esterl, and L. Bjoerck. 1996. Streptococcal cysteine proteinase releases kinins: a novel virulence mechanism. J. Exp. Med. 184:665-673.
24. Kagan, G. Y. 1968. Some aspects of investigations of the pathogenic potentialities of L-forms of bacteria, p. 422-443. In L. B. Guze (ed.), Microbial protoplasts, spheroplasts, and L-forms. The Williams & Wilkins Co., Baltimore, Md.
25. Kagan, G., Yu. Vulfovitch, B. Gusman, and T. Raskova. 1976. Persistence and pathological effect of streptococcal L-forms in vivo. INSERM 65:247-258.
26. Kapur, V., M. W. Majesky, L. L. Li, R. A. Black, and J. M. Musser. 1993. Cleavage of IL-1beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc. Natl. Acad. Sci. USA 90:7676-7680.
27. Kapur, V. S., Topouzis, M. W. Majesky, L. L. Li, M. R. Hamrick, R. J. Hamill, J. M. Patti, and J. M. Musser. 1993. A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin. Microb. Pathog. 15:327-346.
28. Kehoe, M. A. 1994. Cell-wall associated proteins in gram-positive bacteria. New Compr. Biochem. 27:271-261.
29. Kreikemeyer, B., S. R. Talay, and G. S. Chhatwal. 1995. Characterization of a novel fibronectin-binding surface protein in group A streptococci. Mol. Microbiol. 17:137-145.
30. LaPenta, D., C. Rubens, E. Chi, and P. P. Cleary. 1994. Group A streptococci efficiently invade human respiratory epithelial cells. Proc. Natl. Acad. Sci. USA 91:12115-12119.
31. Lazazzera, B. A., J. M. Solomon, and A. G. Grossman. 1997. An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell 89:917-925.
32. Leon, O., and C. Panos. 1976. Adaptation of an osmotically fragile L-form of Streptococcus pyogenes to physiological osmotic condition and its ability to destroy human heart cells in tissue culture. Infect. Immun. 13:252-262.
33. Leonard, B. A. B., and A. Podbielski. Unpublished data.
34. Leonard, B. A. B., A. Podbielski, P. J. Hedberg, and G. M. Dunny. 1996. Enterococcus faecalis pheromone binding protein, PrgZ, recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation. Proc. Natl. Acad. Sci. USA 93:260-264.
35. Lukomski, S., S. Sreevatsan, C. Amberg, W. Reichardt, M. Woischnik, A. Podbielski, and J. M. Musser. 1997. Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains. J. Clin. Invest. 99:2574-2580.
36. McCarty, M. 1966. The nature of the opaque colony variation in group A streptococci. J. Hyg. 64:185-190.
37. McIver, K. S., and J. R. Scott. 1997. Role of mga in growth phase regulation of virulence genes of the group A streptococcus. J. Bacteriol. 179:5178-5187.
38. McIver, K. S., A. S. Heath, and J. R. Scott. 1995. Regulation of virulence by environmental signals in group A streptococci: influence of osmality, temperature, gas exchange, and iron limitation on emm transcription. Infect. Immun. 63:4540-4542.
39. Moses, A. E., M. R. Wessels, K. Zalcman, S. Alberti, S. Natanson-Yaron, T. Menes, and E. Hanski. 1997. Relative contributions of hyaluronic acid capsule and M protein in a mucoid strain to virulence of the group A streptococci. Infect. Immun. 65:64-71.
40. Oesterlund, A., and L. Engstrand. 1997. An intracellular sanctuary for Streptococcus pyogenes in human tonsillar epithelium - studies of asymptomatic carriers and in vitro cultured biopsies. Acta Otolaryngol. 117:883-888.
41. Perez-Casal, J., M. G. Caparon, and J. R. Scott. 1991. Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. J. Bacteriol. 173:2617-2624.
42. Podbielski, A. 1993. Three different types of organization of the vir regulon in group A streptococci. Mol. Gen. Genet. 237:287-300.
43. Podbielski, A., A. Flosdorff, and J. Weber-Heynemann. 1995. The group A streptococcal virR49 gene controls expression of four structural vir regulon genes. Infect. Immun. 63:9-20.
44. Podbielski, A., J. A. Peterson, and P. P. Cleary. 1992. Surface protein CAT reporter fusions demonstrate differential gene expression in the vir regulon of Streptococcus pyogenes. Mol. Microbiol. 68:2253-2265.
45. Podbielski, A., N. Schnitzler, P. Beyhs, and M. D. Boyle. 1996. M-related protein (Mrp) contributes to group A streptococcal resistance to phagocytosis by human granulocytes. Mol. Microbiol. 19:429-441.
46. Podbielski, A., M. Woischnik, B. Pohl, and K. H. Schmidt. 1996. What is the size of the group A streptococal vir regulon? The Mga regulator affects expression of secreted and surface virulence factors. Med. Microbiol. Immunol. 185:171-181.
47. Proctor, R. A., J. M. Balwit, and O. Vesga. 1994. Variant subpopulations of Staphylococcus aureus as cause of persistent and recurrent infections. Infect. Agents Dis. 3:302-312.
48. Proctor, R. A., P. van Langevelde, M. Kristjansson, J. N. Maslow, and R. D. Arbeit. 1995. Persistant and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin. Infect. Dis. 20:95-102.
49. Rakonjac, J. V., J. C. Robbins, and V. A. Fischetti. 1995. DNA sequence of the serum opacity factor of group A streptococci: identification of a fibronectin-binding domain. Infect. Immun. 63:622-631.
50. Schmidt, K.-H., E. Guenther, and H. S. Courtney. 1996. Expression of both M protein and hyaluronic acid capsule by group A streptococcal strains results in a high virulence for chick embryos. Med. Microbiol. Immunol. 184: 168-173.
51. Schmitt-Slomska, J., A. Boue, and R. Caravano. 1972. Induction of L-variants in human diploid cells infected by group A streptococci. Infect. Immun. 5:389-399.
52. Schmitt-Slomska, J., G. Drach, and R. Caravano. 1973. Incidence of cellular and humoral factors on group A streptococcal L forms. Ann. Microbiol. (Inst. Pasteur) 124B:329-350.
53. Schnitzler, N., G. Haase, A. Buessing, A. Kaufhold, P. Beyhs, and A. Podbielski. 1995. Measuring resistance to phagocytosis of group A and group G streptococci: comparison of direct bactericidal assay and flow cytometry. Med. Microbiol. Immunol. 184:17-22.
54. Shaw, J. H., and D. B. Clewell. 1985. Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis. J. Bacteriol. 164:782-796.
55. Simpson, W. J., and P. P. Cleary. 1987. Expression of M type 12 protein by a group A streptococcus exhibits phaselike variation: evidence for coregulation of colony opacity determinants and M protein. Infect. Immun. 55:2448-2455.
56. Simpson, W. J., D. LaPenta, C. Chen, and P. P. Cleary. 1990. Coregulation of type 12 M protein and streptococcal C5a peptidase genes in group A streptococci: evidence for a virulence regulon controlled by the virR locus. J. Bacteriol. 172:696-700.
57. Stevens, D. L. 1996. Invasive group A streptococcal disease. Infect. Agents Dis. 5:157-166.
58. Van de Rijn, I., and R. E. Kessler. 1980. Growth characteristics of group A streptococci in a new chemically defined medium. Infect. Immun. 27:444-448.
59. Wolf, B. B., C. A. Gibson, V. Kapur, I. M. Hussaini, J. M. Musser, and S. L. Gonias. 1994. Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface. J. Biol. Chem. 269:30682-30687.